NGF Cancer Research Results

NGF, Nerve Growth Factor: Click to Expand ⟱
Source:
Type:
Nerve Growth Factor (NGF) plays a crucial role in the development, maintenance, and survival of certain neurons. Its connection to Alzheimer’s disease (AD) has been well-studied, particularly because of its importance in cholinergic neurons of the basal forebrain, which are notably affected in AD.
-Loss of NGF signaling contributes to cholinergic deficits, a hallmark of AD pathology
Scientific Papers found: Click to Expand⟱
4265- CA,    Potential applications of nanomedicine for treating Parkinson's disease
- Review, Park, NA
*NRF2↑, Carnosic acid (CA) is defined as a natural product synthesized by plants of the Lamiaceae family, known for its potent Nrf2-ARE activating properties and neuroprotective role in early brain injury.
*ARE↑,
*neuroP↑,
*motorD↑, It enhances motor and cognitive function while modulating inflammatory markers in the central nervous system.
*cognitive↑,
*SOD↑, enhancement in the expression of superoxide dismutase, glutathione reductase, γ-glutamate-cysteine ligase modifier subunit, and γ-glutamate-cysteine ligase catalytic subunit, induction of caspase 3 cleavage
*GSR↑,
*NGF↑, Carnosic acid is a phenolic diterpene that promotes the synthesis of NGF in the glioblastoma cell lines and also enhances BDNF production in the dopaminergic neurons.
*BDNF↑,

3875- Carno,    Ionophore Ability of Carnosine and Its Trehalose Conjugate Assists Copper Signal in Triggering Brain-Derived Neurotrophic Factor and Vascular Endothelial Growth Factor Activation In Vitro
- in-vitro, AD, NA
*IronCh↑, copper tuning effect on the ability of l-carnosine and, particularly its conjugate, to activate tyrosine kinase cascade pathways.
*CREB↑, As previously mentioned, Car (10 mM) is able: (i) to activate CREB and CREB related pathways, including BDNF expression and release, by activating Ca2+-related pathways in Caco-2 cell line
*BDNF↑,
*NGF↑, Car induces expression and secretion of NGF and BDNF in U-87 MG cells,
*antiOx↑, while antioxidant, oxygen free-radical scavenge
*ROS↓,

4210- Hup,    A Synopsis of Multitarget Potential Therapeutic Effects of Huperzine A in Diverse Pathologies–Emphasis on Alzheimer’s Disease Pathogenesis
- Review, AD, NA
*neuroP↑, Several studies have reported both cholinergic and non-cholinergic effects of this compound on AD with significant neuroprotective properties.
*AChE↓, Hup A is a potent reversible inhibitor of AChE. By its action on AChE, it enhances the ACh levels which enhances learning and memory.
*Ach↑,
*memory↑,
*NGF↑, Increased levels of ACh augments NGF/BDNF and M1mAChR mediated sAPPα levels which further provides neuroprotection.
*BDNF↑,

3745- MFrot,  MF,    The neurobiological foundation of effective repetitive transcranial magnetic brain stimulation in Alzheimer's disease
- Review, AD, NA
*neuroP↑, neuroprotective actions aimed at mitigatingoxidative stress and inflammation, and intense stimulation of neu-rotrophic factors
*ROS↓,
*Inflam↓,
*5HT↑, increase in serotoninand its metabolites and a change in the properties of serotonergicreceptors.
*cFos↑, in rats, a single session of bothLF- (1 Hz) and HF-rTMS (10 Hz) enhanced c-Fos expression in all exam-ined cortical areas
*Aβ↓, rTMS enhances neuronal viability and counteracts oxidative stressors, such as Aβ and glutamate toxicity, in vitro
*memory↑, downregulation results in memory impairments
*BDNF↑, long-term change in synaptic proteinexpression due to BDNF-TrkB pathway activation following rTMSprotocols
*Ach↑, rTMSincreases ACh levels by modulating AChE activity.
*AChE↓,
*cognitive↑, HF-rTMS (20 Hz) and LF-rTMS (1 Hz)—in termsof neurotransmitter circuits and neurogenic signaling. 142 While bothprotocols improved cognition-related behaviors
*BDNF↑, Notably, rTMS could enhance BDNF and NGF expression irrespec-tive of frequency,
*NGF↑,
*β-catenin/ZEB1↑, both LF-rTMS (1 Hz) and HF-rTMS (10 Hz)protocols enhanced cognitive performance through the activation of β-catenin via the regulation of glycogen synthase kinase-3β (GSK-3β) andTau
*p‑Akt↓, 3 weeks, iTBS reducedinflammation and increased anti-inflammatory molecules, specificallylinked to reversing the downregulation of phosphorylated forms ofAkt and the mammalian target of rapamycin.
*mTOR↓,
*MMP1↓, 6 months, patients showed significant reductions in plasma levels of MMP1, MMP9, and MMP10, along with increases in TIMP1 and TIMP2
*MMP9↓,
*MMP-10↓,
*TIMP1↑,
*TIMP2↑,

3814- mushLions,    Lion's Mane (Hericium erinaceus) Exerts Anxiolytic Effects in the rTg4510 Tau Mouse Model
- in-vitro, AD, NA
*neuroP↑, Despite neurocognitive and neurobiological effects of H. erinaceus being seen in both healthy and transgenic mice,
*cognitive↑, Tau mice given H. erinaceus had significantly shorter latencies to enter the center of the open field (OF) (p < 0.05) and spent significantly more time in the open arms of the elevated zero maze (EZM) (p < 0.001) compared to tau control mice
*cognitive∅, While H. erinaceus had anxiolytic effects, no improvements were seen in spatial memory or activities of daily living.
*BBB↑, cross the blood brain barrier (BBB)
*NGF↑, Additional benefits of H. erinaceus include the promotion of nerve growth factor (NGF)
*BDNF↑, promotion of brain-derived neurotrophic factor (BDNF), improvement of cognitive function
*NO↓, reduction in nitric oxide (NO)
*memory↑, Mice receiving H. erinaceus had improved recognition memory and exploratory behavior in the novel object recognition task; this increased exploratory behavior toward novel objects was indicative of lower levels of anxiety
*Aβ↓, Researchers have also found that H. erinaceus can reduce Aβ plaque formation in the APPswe/PS1dE9 mouse model receiving erinacine

3948- Shank,    Neuroprotective role of Convolvulus pluricaulis on aluminium induced neurotoxicity in rat brain
- in-vivo, AD, NA
*AChE↓, Daily administration of CP (150 mg/kg) for 3 months along with aluminium chloride (50 mg/kg) decreased the elevated enzymatic activity of acetylcholine esterase and also inhibited the decline in Na(+)/K(+)ATPase activity which resulted from aluminium
*ChAT↑, Oral administration of CP preserved the mRNA levels of muscarinic receptor 1 (M1 receptor), choline acetyl transferase (ChAT) and Nerve Growth Factor-Tyrosine kinase A receptor (NGF-TrkA).
*NGF↑,
*CDK5↓, It also ameliorated the upregulated protein expression of cyclin dependent kinase5 (Cdk5) induced by aluminium.
*neuroP↑, , indicative of its neuroprotective effects.
*MDA↓, Data showed co-treatment of CP to alu- minium treated rats led to a significant reduction in MDA by ∼23% and protein carbonyl by ∼71% as compared to group II.

4321- VitE,    Unraveling the molecular mechanisms of vitamin deficiency in Alzheimer's disease pathophysiology
- Review, AD, NA
*ROS↓, Vitamin E (Tocotrienols and alpha-tocopherol), is a fat-soluble vitamin that protects neural cells from oxidative stress
*cardioP↑, promotes cardiovascular health by preventing clotting
*lipid-P↓, It prevents lipid peroxidation, supports docosahexaenoic acid (DHA) transport, and enhances cognition, reduces AD progression, highlighting its importance in maintaining cognitive function and preventing neurodegeneration
*cognitive↑,
*neuroP↑,
*Aβ↓, vitamin E influences gene expression by upregulating genes involved in Aβ clearance, a key factor in AD
*NGF↑, Vitamin E deficiency downregulates nerve growth factor (NGF) and sodium-dependent dopamine transporter, both essential for neuroprotection, neuronal survival, and neurotransmission


Showing Research Papers: 1 to 7 of 7

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 7

Pathway results for Effect on Cancer / Diseased Cells:


Total Targets: 0

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress ⓘ

antiOx↑, 1,   ARE↑, 1,   GSR↑, 1,   lipid-P↓, 1,   MDA↓, 1,   NRF2↑, 1,   ROS↓, 3,   SOD↑, 1,  

Metal & Cofactor Biology ⓘ

IronCh↑, 1,  

Core Metabolism/Glycolysis ⓘ

CREB↑, 1,  

Cell Death ⓘ

p‑Akt↓, 1,  

Transcription & Epigenetics ⓘ

Ach↑, 2,  

Proliferation, Differentiation & Cell State ⓘ

cFos↑, 1,   mTOR↓, 1,  

Migration ⓘ

CDK5↓, 1,   MMP-10↓, 1,   MMP1↓, 1,   MMP9↓, 1,   TIMP1↑, 1,   TIMP2↑, 1,   β-catenin/ZEB1↑, 1,  

Angiogenesis & Vasculature ⓘ

NO↓, 1,  

Barriers & Transport ⓘ

BBB↑, 1,  

Immune & Inflammatory Signaling ⓘ

Inflam↓, 1,  

Synaptic & Neurotransmission ⓘ

5HT↑, 1,   AChE↓, 3,   BDNF↑, 6,   ChAT↑, 1,   NGF↑, 7,  

Protein Aggregation ⓘ

Aβ↓, 3,  

Functional Outcomes ⓘ

cardioP↑, 1,   cognitive↑, 4,   cognitive∅, 1,   memory↑, 3,   motorD↑, 1,   neuroP↑, 6,  
Total Targets: 36

Scientific Paper Hit Count for: NGF, Nerve Growth Factor
1 Carnosic acid
1 Carnosine
1 Huperzine A/Huperzia serrata
1 Magnetic Field Rotating
1 Magnetic Fields
1 Mushroom Lion’s Mane
1 Shankhpushpi
1 Vitamin E
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:1360  State#:%  Dir#:2
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