NGF Cancer Research Results

NGF, Nerve Growth Factor: Click to Expand ⟱
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Nerve Growth Factor (NGF) plays a crucial role in the development, maintenance, and survival of certain neurons. Its connection to Alzheimer’s disease (AD) has been well-studied, particularly because of its importance in cholinergic neurons of the basal forebrain, which are notably affected in AD.
-Loss of NGF signaling contributes to cholinergic deficits, a hallmark of AD pathology
Scientific Papers found: Click to Expand⟱
4265- CA,    Potential applications of nanomedicine for treating Parkinson's disease
- Review, Park, NA
*NRF2↑, Carnosic acid (CA) is defined as a natural product synthesized by plants of the Lamiaceae family, known for its potent Nrf2-ARE activating properties and neuroprotective role in early brain injury.
*ARE↑,
*neuroP↑,
*motorD↑, It enhances motor and cognitive function while modulating inflammatory markers in the central nervous system.
*cognitive↑,
*SOD↑, enhancement in the expression of superoxide dismutase, glutathione reductase, γ-glutamate-cysteine ligase modifier subunit, and γ-glutamate-cysteine ligase catalytic subunit, induction of caspase 3 cleavage
*GSR↑,
*NGF↑, Carnosic acid is a phenolic diterpene that promotes the synthesis of NGF in the glioblastoma cell lines and also enhances BDNF production in the dopaminergic neurons.
*BDNF↑,

3875- Carno,    Ionophore Ability of Carnosine and Its Trehalose Conjugate Assists Copper Signal in Triggering Brain-Derived Neurotrophic Factor and Vascular Endothelial Growth Factor Activation In Vitro
- in-vitro, AD, NA
*IronCh↑, copper tuning effect on the ability of l-carnosine and, particularly its conjugate, to activate tyrosine kinase cascade pathways.
*CREB↑, As previously mentioned, Car (10 mM) is able: (i) to activate CREB and CREB related pathways, including BDNF expression and release, by activating Ca2+-related pathways in Caco-2 cell line
*BDNF↑,
*NGF↑, Car induces expression and secretion of NGF and BDNF in U-87 MG cells,
*antiOx↑, while antioxidant, oxygen free-radical scavenge
*ROS↓,

6650- Cen,    Therapeutic Potential of Centella asiatica and Its Triterpenes: A Review
- Review, AD, NA
*BioAv↝, madecassoside, asiaticoside, madecassic acid, and asiatic acid are widely distributed in the body and madecassoside, asiaticoside may exert their biological activity through converted into aglycone (madecassic acid, and asiatic acid).
*BioAv↝, C. asiatica enhances the function of the nervous system. It dissolves in methanol, ethanol, and water.
*MDA↓, Male Wistar rats – MDA ↓, GSH ↑, SOD ↑, AChE↓
*GSH↑,
*SOD↑,
*AChE↓,
*memory↑, Male SD rats; hippocampal cell – Spatial working memory↑, Ki-67 cells↑
*Ki-67↑,
*Catalase↑, Male SD rats MAPK SOD↑, LPO↑, CAT↑, GSH↑, dopamine↑, glutamate↑, Syn1↑, Stx1A↑, PI3K↑, PDK1↑, PEBP↓, VMAT2↑, TH ↑, MAPK ↑, BDNF↑, NGF↑
*PI3K↑,
*BDNF↑,
*NGF↑,
*ROS↓, Water extract of CA Tg2576 mice – ROS↓, NRF2↑, GCLC↑, HMOX1↑, NQO1↑, ATP↑, Mt-ND1↑, Mt-ATP6↑, Mt-CO1↑, Mt-CYB↑, oxygen consumption rate↑
*NRF2↑,
*HO-1↑,
*NQO1↑,
*ATP↑,
*OCR↑,
*TNF-α↓, Ethanolic extract of CA Male SD rats – TNF-α↓, BDNF↑
*PP2A↑, Ethanolic extract of CA Male albino Wistar rats PP2A/GSK-3B PP2A↑, GSK-3B↓, Bcl-2↑
*GSK‐3β↓,
*Bcl-2↑,
*TrkB↑, Standardized extract of CA Male Wistar rats – NR2A↑, NR2B↑, BDNF↑,TrkB↑
*NOTCH1↑, Asiatic acid Male SD rats – Notch1↑, SOX2↑, DCX↑, Nrf2↑, nestin↑, p21 positive cells↓, MDA↓
*SOX2↑,
*Nestin↑,
*MDA↓,
*MAOA↓, Asiaticoside-D Worms – MAO-A↓, MAO-B↓
*MAOB↓,
*GPx↑, Previous studies found that C. asiatica and its triterpenoids could effectively increase SOD and GPX activities, activate nuclear factor erythroid-2-related factor 2, improve the cognitive impairment of animals,
*cognitive↑,
*ROS↓, C. asiatica and its triterpenoids could reduce ROS production
*neuroP↑, they reduced related nerve cell apoptosis, increased synaptic density, and improved the survival rate of neural cells
*glucose↓, Methanol extract of CA Male SD rats – Blood glucose ↓, food and water intake ↓, ALT↓, AST↓, PFK ↑, GS ↑, GP↑, glycogen content ↑
*ALAT↓,
*AST↓,
*PFK↓,
*Weight↓, inhibit weight gain
*Inflam↓, (4) ameliorate inflammation,
*AntiDiabetic↑, C. asiatica extract and related components (asiatic acid, madecassoside) for the treatment of endocrine diseases such as diabetes, obesity and osteoporosis are excellent.
*Obesity↓,
*Wound Healing↑, The C. asiatica extract and its triterpenoids had certain therapeutic and relieving effects on acne, baldness, vitiligo, atopic dermatitis, and wounds. C. asiatica extract can effectively promote wound healing in diabetic patients
*cardioP↑, C. asiatica has a positive effect on cardiovascular diseases.
*GutMicro↑, C. asiatica and its triterpenoids also have therapeutic effects on digestive disorders, which is mainly reflected by improved liver fibrosis, colitis, and gastric mucosal damage; and even reduced Helicobacter pylori gastric colonization
*Sepsis↓, Asiatic acid can improve the side effects caused by antibiotics, reverse multidrug resistance (MDR), and reduce sepsis.
*BioAv↑, C. asiatica cream containing 5.12% asiaticoside and 5.1% madecassoside can be completely absorbed by the skin and effectively improve pigmentation and may be used in treating hypertrophic scars

6780- EGCG,    The pharmacological activity of epigallocatechin-3-gallate (EGCG) on Alzheimer's disease animal model: A systematic review
- Review, AD, NA
*neuroP↑, Regulation of α-, β-, γ-secretase activity, inhibition of tau phosphorylation, anti-oxidation, anti-inflammation, anti-apoptosis, and inhibition of AchE activity are reported as the main neuroprotective mechanisms.
*tau↓,
*antiOx↑,
*Inflam↓,
*Apoptosis↓,
*AChE↓,
*TNF-α↓, Inhibiting TNF-α/JNK pathway
*JNK↓,
*NGF↑, Increasing the level of NGF. EGCG (2 mg/kg) mouse
*SOD↑, figure 7
*GPx↑, EGCG enhanced the activity of T-SOD and GSH-Px and reduced MDA content in the hippocampus.
*MDA↓,
*NO↓,
*ROS↓,
*iNOS↓,
*COX2↓, anti apoptosis
*BAX↓, EGCG prevented LPS-induced elevation of GFAP, iNOS, and COX-2.
*CHOP↓,
*GRP78/BiP↓,
*Bcl-2↑,
*Dose↑, The highest safe dose for more than a month of treatment allowed by FDA is 800 mg of EGCG daily with food.
*BioAv↑, In preclinical and phase I clinical trials, it has been shown that bioavailability of EGCG is increased when it is consumed on a fasting basis.
*hepatoP↓, However, the rate of hepatotoxicity is also increased

4210- Hup,    A Synopsis of Multitarget Potential Therapeutic Effects of Huperzine A in Diverse Pathologies–Emphasis on Alzheimer’s Disease Pathogenesis
- Review, AD, NA
*neuroP↑, Several studies have reported both cholinergic and non-cholinergic effects of this compound on AD with significant neuroprotective properties.
*AChE↓, Hup A is a potent reversible inhibitor of AChE. By its action on AChE, it enhances the ACh levels which enhances learning and memory.
*Ach↑,
*memory↑,
*NGF↑, Increased levels of ACh augments NGF/BDNF and M1mAChR mediated sAPPα levels which further provides neuroprotection.
*BDNF↑,

3745- MFrot,  MF,    The neurobiological foundation of effective repetitive transcranial magnetic brain stimulation in Alzheimer's disease
- Review, AD, NA
*neuroP↑, neuroprotective actions aimed at mitigatingoxidative stress and inflammation, and intense stimulation of neu-rotrophic factors
*ROS↓,
*Inflam↓,
*5HT↑, increase in serotoninand its metabolites and a change in the properties of serotonergicreceptors.
*cFos↑, in rats, a single session of bothLF- (1 Hz) and HF-rTMS (10 Hz) enhanced c-Fos expression in all exam-ined cortical areas
*Aβ↓, rTMS enhances neuronal viability and counteracts oxidative stressors, such as Aβ and glutamate toxicity, in vitro
*memory↑, downregulation results in memory impairments
*BDNF↑, long-term change in synaptic proteinexpression due to BDNF-TrkB pathway activation following rTMSprotocols
*Ach↑, rTMSincreases ACh levels by modulating AChE activity.
*AChE↓,
*cognitive↑, HF-rTMS (20 Hz) and LF-rTMS (1 Hz)—in termsof neurotransmitter circuits and neurogenic signaling. 142 While bothprotocols improved cognition-related behaviors
*BDNF↑, Notably, rTMS could enhance BDNF and NGF expression irrespec-tive of frequency,
*NGF↑,
*β-catenin/ZEB1↑, both LF-rTMS (1 Hz) and HF-rTMS (10 Hz)protocols enhanced cognitive performance through the activation of β-catenin via the regulation of glycogen synthase kinase-3β (GSK-3β) andTau
*p‑Akt↓, 3 weeks, iTBS reducedinflammation and increased anti-inflammatory molecules, specificallylinked to reversing the downregulation of phosphorylated forms ofAkt and the mammalian target of rapamycin.
*mTOR↓,
*MMP1↓, 6 months, patients showed significant reductions in plasma levels of MMP1, MMP9, and MMP10, along with increases in TIMP1 and TIMP2
*MMP9↓,
*MMP-10↓,
*TIMP1↑,
*TIMP2↑,

3814- mushLions,    Lion's Mane (Hericium erinaceus) Exerts Anxiolytic Effects in the rTg4510 Tau Mouse Model
- in-vitro, AD, NA
*neuroP↑, Despite neurocognitive and neurobiological effects of H. erinaceus being seen in both healthy and transgenic mice,
*cognitive↑, Tau mice given H. erinaceus had significantly shorter latencies to enter the center of the open field (OF) (p < 0.05) and spent significantly more time in the open arms of the elevated zero maze (EZM) (p < 0.001) compared to tau control mice
*cognitive∅, While H. erinaceus had anxiolytic effects, no improvements were seen in spatial memory or activities of daily living.
*BBB↑, cross the blood brain barrier (BBB)
*NGF↑, Additional benefits of H. erinaceus include the promotion of nerve growth factor (NGF)
*BDNF↑, promotion of brain-derived neurotrophic factor (BDNF), improvement of cognitive function
*NO↓, reduction in nitric oxide (NO)
*memory↑, Mice receiving H. erinaceus had improved recognition memory and exploratory behavior in the novel object recognition task; this increased exploratory behavior toward novel objects was indicative of lower levels of anxiety
*Aβ↓, Researchers have also found that H. erinaceus can reduce Aβ plaque formation in the APPswe/PS1dE9 mouse model receiving erinacine

3948- Shank,    Neuroprotective role of Convolvulus pluricaulis on aluminium induced neurotoxicity in rat brain
- in-vivo, AD, NA
*AChE↓, Daily administration of CP (150 mg/kg) for 3 months along with aluminium chloride (50 mg/kg) decreased the elevated enzymatic activity of acetylcholine esterase and also inhibited the decline in Na(+)/K(+)ATPase activity which resulted from aluminium
*ChAT↑, Oral administration of CP preserved the mRNA levels of muscarinic receptor 1 (M1 receptor), choline acetyl transferase (ChAT) and Nerve Growth Factor-Tyrosine kinase A receptor (NGF-TrkA).
*NGF↑,
*CDK5↓, It also ameliorated the upregulated protein expression of cyclin dependent kinase5 (Cdk5) induced by aluminium.
*neuroP↑, , indicative of its neuroprotective effects.
*MDA↓, Data showed co-treatment of CP to alu- minium treated rats led to a significant reduction in MDA by ∼23% and protein carbonyl by ∼71% as compared to group II.

4321- VitE,    Unraveling the molecular mechanisms of vitamin deficiency in Alzheimer's disease pathophysiology
- Review, AD, NA
*ROS↓, Vitamin E (Tocotrienols and alpha-tocopherol), is a fat-soluble vitamin that protects neural cells from oxidative stress
*cardioP↑, promotes cardiovascular health by preventing clotting
*lipid-P↓, It prevents lipid peroxidation, supports docosahexaenoic acid (DHA) transport, and enhances cognition, reduces AD progression, highlighting its importance in maintaining cognitive function and preventing neurodegeneration
*cognitive↑,
*neuroP↑,
*Aβ↓, vitamin E influences gene expression by upregulating genes involved in Aβ clearance, a key factor in AD
*NGF↑, Vitamin E deficiency downregulates nerve growth factor (NGF) and sodium-dependent dopamine transporter, both essential for neuroprotection, neuronal survival, and neurotransmission


Showing Research Papers: 1 to 9 of 9

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 9

Pathway results for Effect on Cancer / Diseased Cells:


Total Targets: 0

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↑, 2,   ARE↑, 1,   Catalase↑, 1,   GPx↑, 2,   GSH↑, 1,   GSR↑, 1,   HO-1↑, 1,   lipid-P↓, 1,   MDA↓, 4,   NQO1↑, 1,   NRF2↑, 2,   ROS↓, 6,   SOD↑, 3,  

Metal & Cofactor Biology(tgid=2) ⓘ

IronCh↑, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

ATP↑, 1,   OCR↑, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

ALAT↓, 1,   CREB↑, 1,   glucose↓, 1,   PFK↓, 1,  

Cell Death(tgid=5) ⓘ

p‑Akt↓, 1,   Apoptosis↓, 1,   BAX↓, 1,   Bcl-2↑, 2,   iNOS↓, 1,   JNK↓, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

Ach↑, 2,  

Protein Folding & ER Stress(tgid=8) ⓘ

CHOP↓, 1,   GRP78/BiP↓, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

cFos↑, 1,   GSK‐3β↓, 1,   mTOR↓, 1,   Nestin↑, 1,   NOTCH1↑, 1,   PI3K↑, 1,   SOX2↑, 1,  

Migration(tgid=13) ⓘ

CDK5↓, 1,   Ki-67↑, 1,   MMP-10↓, 1,   MMP1↓, 1,   MMP9↓, 1,   TIMP1↑, 1,   TIMP2↑, 1,   β-catenin/ZEB1↑, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

NO↓, 2,  

Barriers & Transport(tgid=15) ⓘ

BBB↑, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

COX2↓, 1,   Inflam↓, 3,   TNF-α↓, 2,  

Synaptic & Neurotransmission(tgid=18) ⓘ

5HT↑, 1,   AChE↓, 5,   BDNF↑, 7,   ChAT↑, 1,   MAOA↓, 1,   NGF↑, 9,   tau↓, 1,   TrkB↑, 1,  

Protein Aggregation(tgid=19) ⓘ

Aβ↓, 3,   MAOB↓, 1,   PP2A↑, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↑, 2,   BioAv↝, 2,   Dose↑, 1,  

Clinical Biomarkers(tgid=22) ⓘ

ALAT↓, 1,   AST↓, 1,   GutMicro↑, 1,   Ki-67↑, 1,  

Functional Outcomes(tgid=23) ⓘ

AntiDiabetic↑, 1,   cardioP↑, 2,   cognitive↑, 5,   cognitive∅, 1,   hepatoP↓, 1,   memory↑, 4,   motorD↑, 1,   neuroP↑, 8,   Obesity↓, 1,   Weight↓, 1,   Wound Healing↑, 1,  

Infection & Microbiome(tgid=24) ⓘ

Sepsis↓, 1,  
Total Targets: 79

Scientific Paper Hit Count for: NGF, Nerve Growth Factor
1 Carnosic acid
1 Carnosine
1 Centella asiatica / Gotu kola → asiaticoside
1 EGCG (Epigallocatechin Gallate)
1 Huperzine A/Huperzia serrata
1 Magnetic Field Rotating
1 Magnetic Fields
1 Mushroom Lion’s Mane
1 Shankhpushpi
1 Vitamin E
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

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