ADAM10 Cancer Research Results

ADAM10, A Disintegrin And Metalloproteinase Domain-Containing Protein 10: Click to Expand ⟱
Source:
Type:
ADAM10 (A Disintegrin And Metalloproteinase Domain-Containing Protein 10) plays a critical protective role in Alzheimer’s disease (AD) due to its function as an α-secretase, an enzyme involved in the non-amyloidogenic processing of the amyloid precursor protein (APP).
-By preventing Aβ accumulation, ADAM10 indirectly reduces amyloid plaques.br> -Downregulation of ADAM10 is observed in AD brains.
-ADAM10 levels are especially diminished in individuals with an APOE4 genotype
Scientific Papers found: Click to Expand⟱
3859- ALC,    Alpha-Secretase ADAM10 Regulation: Insights into Alzheimer’s Disease Treatment
- Review, AD, NA
*ROS↓, *ADAM10↑,
7521- CA,    Protective effects of caffeic acid and caffeic acid phenethyl ester against acrolein-induced neurotoxicity in HT22 mouse hippocampal cells
- in-vitro, AD, HT22
*neuroP↑, *ROS↓, *GSH↑, *Akt↑, *GSK‐3β↑, *BACE/β-secretase↓, *p38↓, *RAGE↓, *ADAM10↑,
3855- CAP,    Capsaicin consumption reduces brain amyloid-beta generation and attenuates Alzheimer’s disease-type pathology and cognitive deficits in APP/PS1 mice
- in-vivo, AD, NA
*Risk↓, *Aβ↓, *p‑tau↓, *Inflam↓, *neuroP↑, *cognitive↑, *ADAM10↑, *PPARα↑,
3856- CUR,    Curcumin induces IL-6 receptor shedding via the ADAM10 proteinase
- in-vitro, AD, NA
*ADAM10↑, *Inflam↓,
3862- CUR,  RES,    The metalloproteinase ADAM10: A useful therapeutic target?
- Review, AD, NA
*SIRT1↑, *ADAM10↑,
7829- FA,  MBS,    Neuroprotective Potential of Mung Bean (Vigna radiata L.) Polyphenols in Alzheimer's Disease: A Review
- Review, AD, NA
*BioAv↑, *cognitive↓, *Dose↝, *neuroP↑, *Aβ↓, *BACE/β-secretase↓, *ADAM10↑, *Ac-histone H3↑, *BloodF↑, *IRes↑, *memory↑, *Dose↝,
4302- Gins,    Panax ginseng: A modulator of amyloid, tau pathology, and cognitive function in Alzheimer's disease
- Review, AD, NA
*neuroP↑, *Aβ↓, *p‑tau↓, *cognitive↑, *eff↑, *PKA↑, *CREB↑, *BACE/β-secretase↓, *ADAM10↑, *MAPK↑, *ERK↑, *PI3K↑, *Akt↑, *NRF2↑, *PPARγ↓, *IDE↑, *APP↓, *PP2A↑, *memory↑,
7782- ISL,  BUT,  SCP,    Butein, isoliquiritigenin, and scopoletin attenuate neurodegeneration via antioxidant enzymes and SIRT1/ADAM10 signaling pathway
- in-vitro, AD, SH-SY5Y
*Inflam↓, *AntiBio↑, *antiOx↑, *Apoptosis↓, *ROS↓, *SIRT1↑, *FOXO3↑, *ADAM10↑, *Bcl-2↝, *Catalase↑, *SOD2↑, *neuroP↑, *GSR↑, *GPx↑, *GSH↑,
7828- Myr,  MBS,    Neuroprotective Potential of Mung Bean (Vigna radiata L.) Polyphenols in Alzheimer's Disease: A Review
- Review, AD, NA
*BBB↑, *neuroP↑, *cognitive↑, *Aβ↓, *ADAM10↑, *BACE/β-secretase↝, *IronCh↑, *Iron↓, *AChE↓, *ROS↓,
3858- RES,    Alpha-Secretase ADAM10 Regulation: Insights into Alzheimer’s Disease Treatment
- Review, AD, NA
*neuroP↑, *antiOx↑, *LDL↓, *ADAM10↑,
3863- RES,  MEL,  VitA,RetA,    Target Enzymes Considered for the Treatment of Alzheimer's Disease and Parkinson's Disease
- Review, AD, NA - Review, Park, NA
*ADAM10↑, *ADAM10↑, *ADAM10↑,
4284- RES,    Resveratrol induces dephosphorylation of Tau by interfering with the MID1-PP2A complex
- in-vitro, AD, HEK293 - NA, Stroke, NA - in-vivo, AD, NA
*p‑tau↓, *PP2A↑, *neuroP↑, *antiOx↑, COX2/PTGS2↓, *AntiAg↑, *SIRT1↑, *AMPK↑, *Acetyl-CoA↓, *FAO↑, *ADAM10↑, *BACE/β-secretase↓, *Aβ↓, *memory↑, *Inflam↓, *ROS↓,

Showing Research Papers: 1 to 12 of 12

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 12

Pathway results for Effect on Cancer / Diseased Cells:


Immune & Inflammatory Signaling(tgid=16) ⓘ

COX2/PTGS2↓, 1,  
Total Targets: 1

Pathway results for Effect on Normal Cells:


NA, unassigned(tgid=0) ⓘ

AntiBio↑, 1,   IRes↑, 1,  

Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↑, 3,   Catalase↑, 1,   GPx↑, 1,   GSH↑, 2,   GSR↑, 1,   Iron↓, 1,   NRF2↑, 1,   ROS↓, 5,   SOD2↑, 1,  

Metal & Cofactor Biology(tgid=2) ⓘ

IronCh↑, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

Ac-histone H3↑, 1,   Acetyl-CoA↓, 1,   AMPK↑, 1,   CREB↑, 1,   FAO↑, 1,   LDL↓, 1,   PPARα↑, 1,   PPARγ↓, 1,   SIRT1↑, 3,  

Cell Death(tgid=5) ⓘ

Akt↑, 2,   Apoptosis↓, 1,   Bcl-2↝, 1,   MAPK↑, 1,   p38↓, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

ERK↑, 1,   FOXO3↑, 1,   GSK‐3β↑, 1,   PI3K↑, 1,  

Migration(tgid=13) ⓘ

AntiAg↑, 1,   APP↓, 1,   PKA↑, 1,   RAGE↓, 1,  

Barriers & Transport(tgid=15) ⓘ

BBB↑, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

Inflam↓, 4,  

Synaptic & Neurotransmission(tgid=18) ⓘ

AChE↓, 1,   ADAM10↑, 14,   p‑tau↓, 3,  

Protein Aggregation(tgid=19) ⓘ

Aβ↓, 5,   BACE/β-secretase↓, 4,   BACE/β-secretase↝, 1,   IDE↑, 1,   PP2A↑, 2,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↑, 1,   Dose↝, 2,   eff↑, 1,  

Clinical Biomarkers(tgid=22) ⓘ

BloodF↑, 1,   RAGE↓, 1,  

Functional Outcomes(tgid=23) ⓘ

cognitive↓, 1,   cognitive↑, 3,   memory↑, 3,   neuroP↑, 8,   Risk↓, 1,  
Total Targets: 54

Scientific Paper Hit Count for: ADAM10, A Disintegrin And Metalloproteinase Domain-Containing Protein 10
4 Resveratrol
2 Curcumin
2 Mung Bean Sprouts
1 Acetyl-l-carnitine
1 Caffeic acid
1 Capsaicin
1 Ferulic acid
1 Ginseng
1 Isoliquiritigenin
1 Butein
1 Scopoletin
1 Myricetin
1 Melatonin
1 Vitamin A, Retinoic Acid
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:1368  State#:%  Dir#:2
  wNotes=0  sortOrder:rid,rpid

 

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