BOLD Cancer Research Results

BOLD, Blood-Oxygen-Level-Dependent: Click to Expand ⟱
Source:
Type:
BOLD (Blood-Oxygen-Level-Dependent) imaging is a method used in functional magnetic resonance imaging (fMRI) to observe brain activity by detecting changes in blood oxygenation and flow. It plays a significant role in Alzheimer's disease (AD) research for evaluating brain function, especially in early detection and monitoring disease progression.
-Common findings in AD : Reduced BOLD signal in memory-related areas (e.g., hippocampus, posterior cingulate, precuneus, and default mode network)
Scientific Papers found: Click to Expand⟱
3968- ACNs,    Enhanced Neuronal Activation with Blueberry Supplementation in Mild Cognitive Impairment
- Human, AD, NA
*BOLD↑, Following daily supplementation for 16 weeks, blueberry-treated participants exhibited increased BOLD activation in the left pre-central gyrus, left middle frontal gyrus, and left inferior parietal lobe during working memory load conditions
*cognitive?, consistent with prior trials showing neurocognitive benefit with blueberry supplementation in this at-risk population.
*eff↑, High-flavanol cocoa treatment has been associated with enhancement of cerebral blood flow, [9] Concord grape juice [10] and pomegranate juice [11] supplementation with increased regional brain activation, and resveratrol treatment with enhanced hippo

3972- ACNs,    Recent Research on the Health Benefits of Blueberries and Their Anthocyanins
- Review, AD, NA - Review, Park, NA
*cardioP↑, Epidemiological studies associate regular, moderate intake of blueberries and/or anthocyanins with reduced risk of cardiovascular disease, death, and type 2 diabetes, and with improved weight maintenance and neuroprotection.
*neuroP↑,
*Inflam↓, Among the more important healthful aspects of blueberries are their anti-inflammatory and antioxidant actions and their beneficial effects on vascular and glucoregulatory function
*antiOx↓,
*GutMicro↑, Blueberry phytochemicals may affect gastrointestinal microflora and contribute to host health
*Half-Life↑, However, >50% of the 13C still remained in the body after 48 h
*LDL↓, controlled study of 58 diabetic patients, blueberry intake led to a decline in LDL cholesterol, triglycerides, and adiponectin and an increase in HDL cholesterol
*adiP↓,
*HDL↑,
*CRP↓, reduction was documented in inflammatory markers, including serum high-sensitivity C-reactive protein, soluble vascular adhesion molecule-1, and plasma IL-1β
*IL1β↓,
*Risk↓, lower Parkinson disease risk was associated with the highest quintile of anthocyanin (RR: 0.76) and berry (RR: 0.77) intake
*Risk↓, Nurse's Health Study, greater intake of blueberries and strawberries was associated with slower rates of cognitive decline in older adults, with an estimated delay in decline of about 2.5 y
*cognitive↑, Cognitive performance in elderly adults improved after 12 wk of daily intake of blueberry (94) or Concord grape (95) juice.
*memory↑, Better task switching and reduced interference in memory was found in healthy older adults after 90 d of blueberry supplementation
*other↑, After 12 wk of blueberry consumption, greater brain activity was detected using magnetic resonance imaging in healthy older adults during a cognitive challenge.
*BOLD↑, Similarly, during a memory test, regional blood oxygen level-dependent activity detected by MRI (99) was enhanced in the subjects taking blueberry, but not in those taking placebo.
*NO↓, 50–200 mg/d bilberry showed a dose-dependent decrease in neurotoxic NO and malondialdehyde, combined with an increase in neuroprotective antioxidant capacity due to glutathione, vitamin C, superoxide dismutase, and glutathione peroxidase
*MDA↓,
*GSH↑,
*VitC↑,
*SOD↑,
*GPx↑,
*eff↓, The percentage loss of blueberry anthocyanins during −18°C storage was 12% after 10 mo of storage
*eff↓, Freeze-dried blueberry powder loses anthocyanins in a temperature-dependent manner with a half-life of 139, 39, and 12 d when stored at 25, 42, and 60°C, respectively
*eff↓, Blueberries are low in ascorbic acid and high in anthocyanins (187), and notably anthocyanins are readily degraded by ascorbic acid
*eff↝, Shelf-stable blueberry products like jam (196), juice (197), and extracts (198) can lose polyphenolic compounds when stored at ambient temperature whereas refrigeration mitigates losses.
*Risk↓, It can be safely stated that daily moderate intake (50 mg anthocyanins, one-third cup of blueberries) can mitigate the risk of diseases and conditions of major socioeconomic importance in the Western world.


Showing Research Papers: 1 to 2 of 2

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 2

Pathway results for Effect on Cancer / Diseased Cells:


Total Targets: 0

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress ⓘ

antiOx↓, 1,   GPx↑, 1,   GSH↑, 1,   HDL↑, 1,   MDA↓, 1,   SOD↑, 1,   VitC↑, 1,  

Core Metabolism/Glycolysis ⓘ

adiP↓, 1,   LDL↓, 1,  

Transcription & Epigenetics ⓘ

other↑, 1,  

Angiogenesis & Vasculature ⓘ

NO↓, 1,  

Immune & Inflammatory Signaling ⓘ

CRP↓, 1,   IL1β↓, 1,   Inflam↓, 1,  

Drug Metabolism & Resistance ⓘ

eff↓, 3,   eff↑, 1,   eff↝, 1,   Half-Life↑, 1,  

Clinical Biomarkers ⓘ

CRP↓, 1,   GutMicro↑, 1,  

Functional Outcomes ⓘ

BOLD↑, 2,   cardioP↑, 1,   cognitive?, 1,   cognitive↑, 1,   memory↑, 1,   neuroP↑, 1,   Risk↓, 3,  
Total Targets: 27

Scientific Paper Hit Count for: BOLD, Blood-Oxygen-Level-Dependent
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:1369  State#:%  Dir#:2
  wNotes=on  sortOrder:rid,rpid

 

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