BrainVol Cancer Research Results

BrainVol, Hippocampal Volume: Click to Expand ⟱
Source:
Type:
Brain volume is a key biomarker in Alzheimer’s disease (AD) and is closely associated with the progression of the disease
-AD is characterized by progressive brain shrinkage (atrophy)
-Hippocampus: One of the earliest and most affected areas; crucial for memory formation.
-Medial Temporal Lobe: Including the entorhinal cortex; important in converting short-term to long-term memory.
-Parietal and Frontal Lobes: Atrophy spreads here as the disease progresses, affecting language, spatial awareness, and executive function.
-MRI imaging is widely used to measure brain volume loss.
-Rate of volume loss can predict cognitive decline and transition from:
-Normal aging → Mild Cognitive Impairment (MCI) → Alzheimer’s Disease.

Rate of Brain Volume Loss
  Population Group	Estimated Brain Volume Loss / Year
  Healthy aging adults	~0.2–0.5%
  MCI patients	        ~1–2%
  AD patients	        ~2–3% or more


Scientific Papers found: Click to Expand⟱
4139- Ex,    Impact of physical exercise on the regulation of brain-derived neurotrophic factor in people with neurodegenerative diseases
- Review, AD, NA
*BDNF↑, recent studies are analyzed that indicate an increase in BDNF levels following physical activity, particularly in young adults.
*eff↑, with the most significant effects seen in aerobic and high-intensity exercises.
*eff↑, Both acute and prolonged exercise increase BDNF, but the effect is more sustained with regular, long-term regimens.
*cognitive↑, Prolonged aerobic exercise increases BDNF and improves vascular and cognitive functions, with positive effects observed in older adults.
*memory↑, In animal models, forced and voluntary exercise increased hippocampal BDNF, improving spatial memory and synaptic function.
*BrainVol↑,
*TrkB↑, The interaction of BDNF with its receptor TrkB is involved in the processes that lead to enhancements in learning and memory associated with exercise
*GABA↑, BDNF increases the expression of markers associated with GABAergic neurotransmission, such as GABA, GAD65, and GAD67

6961- FA,  VitB12,  VitB6,  Silicon,  Alum  B Vitamins Prevent Iron-Associated Brain Atrophy and Domain-Specific Effects of Iron, Copper, Aluminum, and Silicon on Cognition in Mild Cognitive Impairment
- Trial, AD, NA
*BrainVol↝, Baseline iron, cysteine, and homocysteine were significantly associated with brain atrophy rate.
*cognitive↝, At baseline, iron, copper, aluminum, and silicon were significantly associated with one or more domains of cognition: semantic memory, verbal episodic memory, attention/processing speed, and executive function.
*cognitive↑, These factors showed domain-specific associations with cognition, which were abrogated by B vitamin therapy.
*Dose↝, daily folic acid (0.8 mg)/vitamin B12 (0.5 mg)/vitamin B6 (20 mg)
*other↝, Reducing the rate of brain atrophy is likely to slow the conversion of individuals with MCI to AD
*Hcy/homoC↓, Elevated plasma total Hcy (tHcy) is associated with brain atrophy in healthy elderly [6] and in AD patients [7].
*Risk↓, Silicon (Si) has been shown to prevent gastrointestinal absorption of Al [17]
*BrainVol∅, In contrast, we found no correlations between brain atrophy rate and baseline serum Cu, As, or Al
*BrainVol↑, B vitamin treatment abrogates associations of brain atrophy rate with Fe and Cys
*other↝, Baseline Fe, Cu, Al, and Si predict cognition in the placebo group at the end of study: multiple regression analysis
*cognitive↑, B vitamin treatment abrogates effects of Fe, Si, Al, and Cu on cognition
*cognitive↑, multiple regression analyses that baseline Fe and Si were associated with better performance in several domains of cognition at the end of study
*other↝, serum Fe levels were reduced [12] and serum Cu levels were elevated [11] in AD patients compared to healthy controls.
*Risk↝, In addition to Fe and Cu, Al is also known to accumulate in senile plaques [15] and a high daily intake of Al is associated with increased risk of dementia

7140- GI,    Benefits of Ginger and Its Constituent 6-Shogaol in Inhibiting Inflammatory Processes
- Review, Var, NA
*Dose↝, 6-Shogaol is formed from 6-gingerol by dehydration and represents one of the main bioactive principles in dried ginger rhizomes.
*Inflam↓, In vitro and in vivo, 6-shogaol reduced inflammatory mediator systems such as COX-2 or iNOS, affected NFκB and MAPK signaling, and increased levels of cytoprotective HO-1.
*COX2/PTGS2↓,
*iNOS↓,
*NF-kB↓,
*MAPK?,
*HO-1↑,
*PGE2↓, Rat/saline administration 50 and 500 mg/kg extract oral or i.p. Reduced PGE2 serum levels
*TNF-α↓, 25, 50, 100 and 200 mg/kg extract oral Reduced carrageenan-induced paw volume, levels of PGE2, TNF, IL-6, IL-1β, IFNγ, MCP-1, MIP-2, RANTES, and MPO activity and NO levels
*IL6↓,
*IL1β↓,
*IFN-γ↓,
*MCP1/CCL2↓,
*MIP2↓,
*RANTES↓,
*MPO↓,
*NO↓,
*Stroke↓, Therefore, the authors of this study suggest a potential benefit of 6-shogaol for the prevention of stroke [51].
*BrainVol↑, The daily oral administration of 6-shogaol (5 and 20 mg/kg) resulted in protection against transient focal cerebral ischemia, as indicated by a significant reduction of brain infarct volume and production of malondialdehyde (MDA) and of ROS after MCA
*MDA↓,
*ROS↓,
*GSH↑, 6-shoagol treatment resulted in an increased amount of glutathione (GSH) in H2O2-induced HepG2 cells
*NRF2↑, As H2O2-triggered Nrf2 degradation was recovered by 6-shogaol,
*antiOx↑, 6-Shogaol exhibits a stronger antioxidative activity than its homologues
NLRP3↓, 6-shogaol (20 µM) effectively inhibited total protein levels of NLRP3 and pro-IL-1β after a combined LPS and ATP-activated protein up-regulation
HDAC1↓, The LPS-caused induction of HDAC1 protein levels was reduced by 6-shogaol


Showing Research Papers: 1 to 3 of 3

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 3

Pathway results for Effect on Cancer / Diseased Cells:


Proliferation, Differentiation & Cell State(tgid=12) ⓘ

HDAC1↓, 1,  

Protein Aggregation(tgid=19) ⓘ

NLRP3↓, 1,  
Total Targets: 2

Pathway results for Effect on Normal Cells:


NA, unassigned(tgid=0) ⓘ

Stroke↓, 1,  

Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↑, 1,   GSH↑, 1,   HO-1↑, 1,   MDA↓, 1,   MPO↓, 1,   NRF2↑, 1,   ROS↓, 1,  

Cell Death(tgid=5) ⓘ

iNOS↓, 1,   MAPK?, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

other↝, 3,  

Angiogenesis & Vasculature(tgid=14) ⓘ

NO↓, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

COX2/PTGS2↓, 1,   IFN-γ↓, 1,   IL1β↓, 1,   IL6↓, 1,   Inflam↓, 1,   MCP1/CCL2↓, 1,   MIP2↓, 1,   NF-kB↓, 1,   PGE2↓, 1,   RANTES↓, 1,   TNF-α↓, 1,  

Synaptic & Neurotransmission(tgid=18) ⓘ

BDNF↑, 1,   BrainVol↑, 3,   BrainVol↝, 1,   BrainVol∅, 1,   GABA↑, 1,   TrkB↑, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

Dose↝, 2,   eff↑, 2,  

Clinical Biomarkers(tgid=22) ⓘ

Hcy/homoC↓, 1,   IL6↓, 1,  

Functional Outcomes(tgid=23) ⓘ

cognitive↑, 4,   cognitive↝, 1,   memory↑, 1,   Risk↓, 1,   Risk↝, 1,  
Total Targets: 38

Scientific Paper Hit Count for: BrainVol, Hippocampal Volume
1 Exercise
1 Folic Acid, Vit B9
1 Vitamin B12
1 Vitamin B6,pyridoxine
1 Silicic Acid
1 Aluminum
1 Ginger/6-Shogaol/Gingerol
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:1372  State#:%  Dir#:2
  wNotes=on  sortOrder:rid,rpid

 

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