BrainVol Cancer Research Results

BrainVol, Hippocampal Volume: Click to Expand ⟱

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Brain volume is a key biomarker in Alzheimer’s disease (AD) and is closely associated with the progression of the disease
-AD is characterized by progressive brain shrinkage (atrophy)
-Hippocampus: One of the earliest and most affected areas; crucial for memory formation.
-Medial Temporal Lobe: Including the entorhinal cortex; important in converting short-term to long-term memory.
-Parietal and Frontal Lobes: Atrophy spreads here as the disease progresses, affecting language, spatial awareness, and executive function.
-MRI imaging is widely used to measure brain volume loss.
-Rate of volume loss can predict cognitive decline and transition from:
-Normal aging → Mild Cognitive Impairment (MCI) → Alzheimer’s Disease.

Rate of Brain Volume Loss
  Population Group	Estimated Brain Volume Loss / Year
  Healthy aging adults	~0.2–0.5%
  MCI patients	        ~1–2%
  AD patients	        ~2–3% or more

Scientific Papers found: Click to Expand⟱

4139-

Ex,

Impact of physical exercise on the regulation of brain-derived neurotrophic factor in people with neurodegenerative diseases

Review,

AD,

*BDNF↑, recent studies are analyzed that indicate an increase in BDNF levels following physical activity, particularly in young adults.
*eff↑, with the most significant effects seen in aerobic and high-intensity exercises.
*eff↑, Both acute and prolonged exercise increase BDNF, but the effect is more sustained with regular, long-term regimens.
*cognitive↑, Prolonged aerobic exercise increases BDNF and improves vascular and cognitive functions, with positive effects observed in older adults.
*memory↑, In animal models, forced and voluntary exercise increased hippocampal BDNF, improving spatial memory and synaptic function.
*BrainVol↑,
*TrkB↑, The interaction of BDNF with its receptor TrkB is involved in the processes that lead to enhancements in learning and memory associated with exercise
*GABA↑, BDNF increases the expression of markers associated with GABAergic neurotransmission, such as GABA, GAD65, and GAD67

Showing Research Papers: 1 to 1 of 1

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:

Total Targets: 0

Pathway results for Effect on Normal Cells:

Synaptic & Neurotransmission ⓘ

BDNF↑, 1, BrainVol↑, 1, GABA↑, 1, TrkB↑, 1,

Drug Metabolism & Resistance ⓘ

eff↑, 2,

Functional Outcomes ⓘ

cognitive↑, 1, memory↑, 1,
Total Targets: 7

Scientific Paper Hit Count for: BrainVol, Hippocampal Volume

Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells