PhotoS Cancer Research Results

PhotoS, PhotoSensitzer: Click to Expand ⟱
Source:
Type:
PhotoSensitzer: A product that increases reaction to light
Scientific Papers found: Click to Expand⟱
4384- ,    Silver nanoparticles: synthesis, properties, and therapeutic applications
- Review, Var, NA
AntiCan↑, AgNPs are employed in newly emerging applications as photosensitizers/radiosensitizers, antiviral and anticancer agents.
RadioS↑,
CellMemb↑, underlying anticancer mechanisms of AgNPs include (1) disruption of cell membranes, and (2) production of reactive oxygen species and Ag+ to damage protein or DNA.
ROS↑,
DNAdam↑,
PhotoS↑, photosensitizing mechanism of AgNPs is based on nonradiative decay converting photo energy to thermal energy.
eff↑, Smaller particles have a larger surface area and, therefore, have greater toxic potential

5690- BJ,  BRU,    Brusatol: A potential sensitizing agent for cancer therapy from Brucea javanica
- Review, Var, NA
NRF2↓, Brusatol is a potent Nrf2 inhibitor for future cancer treatment.
TumCG↓, Brusatol exhibits significant tumor inhibition in multiple cancers.
ChemoSen↑, also exhibits significant synergistic antitumor effects in combination with chemotherapeutic agents
ROS↑, Graphical Abstract
NF-kB↓,
Akt↓,
mTOR↓,
TumCCA↑,
Apoptosis↑,
PARP↑,
Casp↑,
P53↓,
Bcl-2↓,
PI3K↓,
JAK2↓,
EMT↓,
p27↑,
ROCK1↓,
MMP2↓,
MMP9↓,
NRF2↓, which is the reason why brusatol is called an Nrf2 inhibitor [15]. Brusatol is a potent Nrf2 inhibitor
AntiTum↑, Brusatol shows significant antitumor effects in vitro and in vivo
HO-1↓, Moreover, brusatol inhibited the expression of Nrf2 downstream genes, such as HO-1 [19], [31], [32], NQO1 [43], [44], VEGF [45], and AKR1C1 [46].
NQO1↓,
VEGF↓,
MRP1↓, brusatol reduced both the mRNA and protein levels of NQO1, HO-1, MDR1, and MRP5
RadioS↑, Improvement of sensitivity to radiotherapy and phototherapy
PhotoS↑,
toxicity↝, the toxicity of brusatol is a problem that can not be ignored.

5648- BP,    Combined photothermal and sonodynamic therapy using a 2D black phosphorus nanosheets loaded coating for efficient bacterial inhibition and bone-implant integration
- in-vivo, Nor, NA
sonoS↑, BPNSs as generators of reactive radicals (ROS) under ultrasound (US) stimuli for implant associated infection.
PhotoS↑, Ti/PDA/BP coating exhibits superior biocompatibility, bioactivity, photothermal and sonodynamic conversion abilities.

5646- BP,    Black Phosphorus, an Emerging Versatile Nanoplatform for Cancer Immunotherapy
- Review, Var, NA
ROS↑, BP nanomaterials are capable of producing singlet oxygen, which enable its application as a photosensitizer for photodynamic therapy (PDT).
Imm↑, Recently, it has been reported that BP-based PTT is capable of activating immune responses and alleviating the immunosuppressive tumor microenvironment
PhotoS↑, BP nanomaterials can be applied as photothermal agents (PTA

6081- CHL,    Enhancing Health Benefits through Chlorophylls and Chlorophyll-Rich Agro-Food: A Comprehensive Review
- Review, Nor, NA
*antiOx↑, wide range of beneficial effects, including antioxidant, antimutagenic, antigenotoxic, anti-cancer, and anti-obesogenic activities.
*toxicity↓, Dietary supplements containing chlorophyll and chlorophyllin are available and generally considered safe, with no reported adverse side effects over several decades of human use
*BioAv↓, Due to the poor bioavailability and stability of chlorophylls, studies on chlorophylls are scarce until now.
*BioAv↑, Semi-synthetic sodium copper-chlorophyllins (SCC) . modifications enhance the stability, solubility in water, and accessibility of SCC
*neuroP↑, figure 3
*Obesity↓,
*AntiCan↑, rats subjected to dietary heme, which mimics red meat ingestion, demonstrated that natural chlorophylls inhibit colonic cytotoxicity, proliferation of colonic epithelial cells, epithelial cell turnover, and the formation of lipid radicals induced by
*TumCP↓, SCC has been reported to decrease the proliferation of human pancreatic cancer cell lines in vitro
*PhotoS↑, Chlorophyll acts as a photosensitizer due to its natural ability to absorb light.
*neuroP↑, chlorophyll may exert its neuroprotective effects is through its antioxidant properties. Oxidative stress


Showing Research Papers: 1 to 5 of 5

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 5

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress ⓘ

HO-1↓, 1,   NQO1↓, 1,   NRF2↓, 2,   ROS↑, 3,  

Cell Death ⓘ

Akt↓, 1,   Apoptosis↑, 1,   Bcl-2↓, 1,   Casp↑, 1,   p27↑, 1,  

Transcription & Epigenetics ⓘ

PhotoS↑, 4,   sonoS↑, 1,  

DNA Damage & Repair ⓘ

DNAdam↑, 1,   P53↓, 1,   PARP↑, 1,  

Cell Cycle & Senescence ⓘ

TumCCA↑, 1,  

Proliferation, Differentiation & Cell State ⓘ

EMT↓, 1,   mTOR↓, 1,   PI3K↓, 1,   TumCG↓, 1,  

Migration ⓘ

MMP2↓, 1,   MMP9↓, 1,   ROCK1↓, 1,  

Angiogenesis & Vasculature ⓘ

VEGF↓, 1,  

Barriers & Transport ⓘ

CellMemb↑, 1,  

Immune & Inflammatory Signaling ⓘ

Imm↑, 1,   JAK2↓, 1,   NF-kB↓, 1,  

Drug Metabolism & Resistance ⓘ

ChemoSen↑, 1,   eff↑, 1,   MRP1↓, 1,   RadioS↑, 2,  

Functional Outcomes ⓘ

AntiCan↑, 1,   AntiTum↑, 1,   toxicity↝, 1,  
Total Targets: 34

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress ⓘ

antiOx↑, 1,  

Transcription & Epigenetics ⓘ

PhotoS↑, 1,  

Migration ⓘ

TumCP↓, 1,  

Drug Metabolism & Resistance ⓘ

BioAv↓, 1,   BioAv↑, 1,  

Functional Outcomes ⓘ

AntiCan↑, 1,   neuroP↑, 2,   Obesity↓, 1,   toxicity↓, 1,  
Total Targets: 9

Scientific Paper Hit Count for: PhotoS, PhotoSensitzer
2 Black phosphorus
1 Brucea javanica
1 brusatol
1 Chlorophyllin
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:1377  State#:%  Dir#:2
  wNotes=on  sortOrder:rid,rpid

 

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