PRNP Cancer Research Results

PRNP, Prion Protein (PRioN Protein) gene: Click to Expand ⟱
Source:
Type:
Prion Protein (PRioN Protein) gene
-Upregulation of PRNP → Activates PI3K/Akt, MAPK/ERK, and NF-κB pathways → ↑ cell survival, ↓ apoptosis, ↑ migration/invasion.
-Silencing or downregulation of PRNP often reduces tumor growth and increases chemosensitivity.
Scientific Papers found: Click to Expand⟱
4538- TQ,    Thymoquinone Anticancer Effects Through the Upregulation of NRF2 and the Downregulation of PD‐L1 in MDA‐MB‐231 Triple‐Negative Breast Cancer Cells
- in-vitro, BC, MDA-MB-231 - in-vitro, BC, MDA-MB-468
antiOx↑, TQ exhibits considerable antioxidant activity and decreases the generation of H2O2, at the same time increasing catalase (CAT) activity, superoxide dismutase (SOD) enzyme, and glutathione (GSH).
H2O2↓, Thymoquinone Decreases Hydrogen Peroxide Levels in TNBC
Catalase↑, Thymoquinone Increased Catalase Enzyme Activities in TNBC Cells
SOD↑, Increased Superoxide Dismutase (SOD) Enzyme Activities in Thymoquinone-TreatedTNBC Cells
GSH↑, significant induction of the total GSH and GSSG levels was measured in TQ-treated MDA-MB-231 cells
PRNP↑, TQ treatment increased the levels of the different genes involved in the oxidative stress-antioxidant defense system PRNP, NQO1, and GCLM in both cell lines with significant large-fold change in MDA-MB-468
NQO1↑,
GCLM↑,
NRF2↑, Nrf2 mRNA and protein expression were also significantly increased in TQ-treated TNBC cells
PD-L1↓, , TQ administration increased mRNA levels while decreasing PD-L1 protein expression in both cell lines
chemoPv↑, TQ modifies the expression of multiple oxidative-stress-antioxidant system genes, ROS, antioxidant enzymes, Nrf2, and PD-L1 protein, pointing to the therapeutic potential and chemopreventive utilization of TQ in TNBC
ROS↓, Our study revealed that in the MDA-MB-231 TNBC cell line (Figure 2A), intracellular ROS generation was reduced by 10 (p = 0.0321), 15 (p = 0.0061), and 27% (p = 0.0004) at concentrations of 5, 10, and 15 μM, respectively,


Showing Research Papers: 1 to 1 of 1

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress ⓘ

antiOx↑, 1,   Catalase↑, 1,   GCLM↑, 1,   GSH↑, 1,   H2O2↓, 1,   NQO1↑, 1,   NRF2↑, 1,   ROS↓, 1,   SOD↑, 1,  

Migration ⓘ

PRNP↑, 1,  

Immune & Inflammatory Signaling ⓘ

PD-L1↓, 1,  

Clinical Biomarkers ⓘ

PD-L1↓, 1,  

Functional Outcomes ⓘ

chemoPv↑, 1,  
Total Targets: 13

Pathway results for Effect on Normal Cells:


Total Targets: 0

Scientific Paper Hit Count for: PRNP, Prion Protein (PRioN Protein) gene
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:1380  State#:%  Dir#:2
  wNotes=on  sortOrder:rid,rpid

 

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