ETC Cancer Research Results

ETC, Electron Transport Chain: Click to Expand ⟱
Source:
Type:
The electron transport chain (ETC) — the mitochondrial system that produces ATP through oxidative phosphorylation — is deeply linked to cancer biology, both in tumor promotion and suppression.
-The ETC resides in the inner mitochondrial membrane and includes Complexes I–IV and ATP synthase (Complex V).
-It transfers electrons from NADH/FADH₂ to oxygen, generating ATP and reactive oxygen species (ROS) as byproducts.
-The function of the tricarboxylic acid (TCA) cycle and the mitochondrial electron transport chain (ETC) is to transfer electrons from carbon to oxygen and release energy in the form of ATP.

The #1 theory of how pulsed Magnetic Fields affect the ETC is by the RPM

The ETC consists of:
-Complex I – NADH dehydrogenase
-Complex II – Succinate dehydrogenase
-➡ Complex III – Cytochrome bc₁ complex
-Complex IV – Cytochrome c oxidase
-ATP synthase (often called Complex V)

Complex III sits between Coenzyme Q (ubiquinol) and cytochrome c.

Complex III is a major regulated source of mitochondrial ROS, especially:
-Superoxide generation at the Qo site
-ROS used for redox signaling (HIF stabilization, signaling adaptation)
-Excess ROS contributes to DNA damage and cell death


Scientific Papers found: Click to Expand⟱
6155- CoQ10,    BPGbio Highlights Groundbreaking Data on BPM31510 for Mitochondrial Diseases at the Inaugural Mitochondrial Transplantation and Next Generation Therapeutics Conference
- Review, NA, NA
*CoQ10↑, *BBB↑, *ETC↑, eff↑,
6419- MEL,    The potential influence of melatonin on mitochondrial quality control: a review
- Review, Nor, NA
*mt-ACC⇅, *PKM1↑, *PKM2↑, *Glycolysis↝, *PDKs↑, *FAO↑, *ETC↑, *OXPHOS↑, *ATP↑, Glycolysis↓, OXPHOS↑, *Ca+2↓, *ROS↓, *antiOx↑, *SOD2↑, *GPx↑, *Catalase↑, *MFN1↑, *MFN2↑, *OPA1↑, *YAP/TEAD↑, *Hippo↑, *SIRT1↑, *PGC-1α↑, *DRP1/DNM1L↓,
5254- NCL,    The magic bullet: Niclosamide
- Review, Var, NA
Wnt↓, β-catenin/ZEB1↓, RAS↓, STAT3↓, NOTCH↓, E2Fs↓, mTOR↓, eff↑, PD-1↓, PD-L1↓, BioAv↝, toxicity↓, BioAv↑, ETC↑, NADH:NAD↓, TCA↑, Warburg↓, Diff↑, AMPK↑, P53↑, PP2A↑, HIF-1↓, KRAS↓, Myc↓, RadioS↑, ChemoSen↑, Dose↝, Dose↑,

Showing Research Papers: 1 to 3 of 3

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 3

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

OXPHOS↑, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

ETC↑, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

AMPK↑, 1,   Glycolysis↓, 1,   NADH:NAD↓, 1,   TCA↑, 1,   Warburg↓, 1,  

Cell Death(tgid=5) ⓘ

Myc↓, 1,  

DNA Damage & Repair(tgid=10) ⓘ

P53↑, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

E2Fs↓, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

Diff↑, 1,   mTOR↓, 1,   NOTCH↓, 1,   RAS↓, 1,   STAT3↓, 1,   Wnt↓, 1,  

Migration(tgid=13) ⓘ

KRAS↓, 1,   β-catenin/ZEB1↓, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

HIF-1↓, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

PD-1↓, 1,   PD-L1↓, 1,  

Protein Aggregation(tgid=19) ⓘ

PP2A↑, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↑, 1,   BioAv↝, 1,   ChemoSen↑, 1,   Dose↑, 1,   Dose↝, 1,   eff↑, 2,   RadioS↑, 1,  

Clinical Biomarkers(tgid=22) ⓘ

KRAS↓, 1,   Myc↓, 1,   PD-L1↓, 1,  

Functional Outcomes(tgid=23) ⓘ

toxicity↓, 1,  
Total Targets: 33

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↑, 1,   Catalase↑, 1,   CoQ10↑, 1,   GPx↑, 1,   MFN1↑, 1,   MFN2↑, 1,   OPA1↑, 1,   OXPHOS↑, 1,   ROS↓, 1,   SOD2↑, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

ATP↑, 1,   DRP1/DNM1L↓, 1,   ETC↑, 2,   PGC-1α↑, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

mt-ACC⇅, 1,   FAO↑, 1,   Glycolysis↝, 1,   PDKs↑, 1,   PKM1↑, 1,   PKM2↑, 1,   SIRT1↑, 1,  

Cell Death(tgid=5) ⓘ

Hippo↑, 1,   YAP/TEAD↑, 1,  

Migration(tgid=13) ⓘ

Ca+2↓, 1,  

Barriers & Transport(tgid=15) ⓘ

BBB↑, 1,  
Total Targets: 25

Scientific Paper Hit Count for: ETC, Electron Transport Chain
1 Coenzyme Q10
1 Melatonin
1 Niclosamide (Niclocide)
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:1386  State#:%  Dir#:2
  wNotes=0  sortOrder:rid,rpid

 

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