AntiThr Cancer Research Results

AntiThr, antithrombotic: Click to Expand ⟱
Source:
Type:
An antithrombotic agent is a drug that reduces the formation of blood clots.


Scientific Papers found: Click to Expand⟱
4574- AgNPs,    Advances in nano silver-based biomaterials and their biomedical applications
- Review, NA, NA
*Wound Healing↑, Antimicrobial effect of AgNPs allows effective use in wound healing and dentistry
*AntiThr↑, AgNPs possess antithrombotic activity useful to treat cardiovascular diseases.
*AntiAg↑, Their anti-platelet effects can be attributed to their ability to prevent or inhibit platelets from adhering to each other.
eff↑, AgNPs makes them excellent agents for photothermal therapy in the treatment of tumours and cancers.

4579- AgNPs,    Response of platelets to silver nanoparticles designed with different surface functionalization
*AntiAg↑, Potentially, materials exhibiting antiplatelet activity may be applied in devices that prevent arterial thrombotic events like ischemic stroke, coronary heart disease, and ischemic gangrene.
*AntiThr↑,
*Dose↝, All four types of AgNPs were spherical in shape with the primary size close to 10 nm

4578- AgNPs,    Green synthesized novel silver nanoparticles and their application as anticoagulant and thrombolytic agents: A perspective
- Review, NA, NA
*AntiThr↑, However, advent of biogenic silver nanoparticles with anticoagulant and thrombolytic potentials has opened up a window of opportunity to address most of the shortcomings of the chemical synthesized anticoagulants.

5341- Ajoene,    Ajoene (natural garlic compound): a new anti-leukaemia agent for AML therapy
- Review, AML, NA
eff↑, Ajoene (4,5,9-trithiadodeca-1,6,11-triene-9-oxide) is a garlic-derived compound produced most efficiently from pure allicin and has the advantage of a greater chemical stability than allicin.
AntiThr↑, ajoene have demonstrated its best-known anti-thrombosis, anti-microbial and cholesterol lowering activities.
Bacteria↓,
LDH↓,
TumCP↓, Ajoene was shown to inhibit proliferation and induce apoptosis of several human leukaemia CD34-negative cells including HL-60, U937, HEL and OCIM-1
TumCCA↑, Studies have shown the anti-proliferation activity of ajoene to be associated with a block in the G2/M phase of cell cycle in human myeloid leukaemia cells.
Bcl-2↓, The apoptosis inducing activity of ajoene is via the mitochondria-dependent caspase cascade through a significant reduction of the anti-apoptotic bcl-2 that results in release of cytochrome c and the activation of caspase-3.
Cyt‑c↑,
Casp3↑,

4575- RT,  AgNPs,    Rutin-Loaded Silver Nanoparticles With Antithrombotic Function
- in-vivo, NA, NA
*AntiThr↑, Rutin@AgNPs is a potential anticoagulant for antithrombotic therapy
*AntiAg↑, rutin effectively targets the PDI and inhibits its activity, thus the platelet accumulation and fibrin generation can be blocked
*antiOx↑, rutin is a kind of flavonoid, which contains antioxidation and anti-inflammatory activities.
*Inflam↓,


Showing Research Papers: 1 to 5 of 5

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 5

Pathway results for Effect on Cancer / Diseased Cells:


Core Metabolism/Glycolysis ⓘ

LDH↓, 1,  

Cell Death ⓘ

Bcl-2↓, 1,   Casp3↑, 1,   Cyt‑c↑, 1,  

Transcription & Epigenetics ⓘ

AntiThr↑, 1,  

Cell Cycle & Senescence ⓘ

TumCCA↑, 1,  

Migration ⓘ

TumCP↓, 1,  

Drug Metabolism & Resistance ⓘ

eff↑, 2,  

Clinical Biomarkers ⓘ

LDH↓, 1,  

Infection & Microbiome ⓘ

Bacteria↓, 1,  
Total Targets: 10

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress ⓘ

antiOx↑, 1,  

Transcription & Epigenetics ⓘ

AntiThr↑, 4,  

Migration ⓘ

AntiAg↑, 3,  

Immune & Inflammatory Signaling ⓘ

Inflam↓, 1,  

Drug Metabolism & Resistance ⓘ

Dose↝, 1,  

Functional Outcomes ⓘ

Wound Healing↑, 1,  
Total Targets: 6

Scientific Paper Hit Count for: AntiThr, antithrombotic
4 Silver-NanoParticles
1 Ajoene (compound of Garlic)
1 Rutin
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:1388  State#:%  Dir#:2
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