FTO Cancer Research Results

FTO, Fat mass and obesity-associated protein: Click to Expand ⟱
Source:
Type:
FTO Fat mass and obesity-associated protein
FTO is often upregulated in CSCs, where it:
-promotes stemness
-increases sphere formation
-increases tumor initiation
-induces chemoresistance

High FTO promotes EMT by:
↓ E-cadherin
↑ Vimentin
↑ Slug/Snail signaling
FTO-high tumors show increased invasion and metastatic potential.


Scientific Papers found: Click to Expand⟱
5555- BBM,    Berbamine inhibits cell proliferation and invasion by increasing FTO expression in renal cell carcinoma cells
- vitro+vivo, RCC, NA
TumCP↓, BBM effectively inhibited the proliferation, migration and invasion of RCC cells in a dose-dependent manner
TumCMig↓,
TumCI↓,
TumCG↓, and BBM also significantly inhibited the growth of tumor in vivo,
toxicity↓, which has fewer toxic effects on the other organs.
FTO↑, mechanistic studies showed that BBM significantly promoted the expression of FTO mRNA and protein in RCC cells,

4658- BBR,    Berberine Suppresses Stemness and Tumorigenicity of Colorectal Cancer Stem-Like Cells by Inhibiting m6A Methylation
- in-vitro, CRC, HCT116 - in-vitro, CRC, HT29
CSCs↓, Our observation that Berberine effectively decreased m6A methylation by decreasing β-catenin and subsequently increased FTO suggests a role of Berberine in modulating stemness and malignant behaviors in colorectal CSCs.
TumCP↓, Berberine treatment decreased cell proliferation by decreasing cyclin D1 and increasing p27 and p21 and subsequently induced cell cycle arrest at the G1/G0 phase.
cycD1/CCND1↓,
p27↑,
P21↑,
TumCCA↑,
Apoptosis↑, Berberine treatment also decreased colony formation and induced apoptosis.
ChemoSen↑, Berberine treatment also increased chemosensitivity in CSCs and promoted chemotherapy agent-induced apoptosis.
β-catenin/ZEB1↓, Berberine treatment increased FTO by decreasing β-catenin, which is a negative regulator of FTO.
FTO↑,
CD44↓, Consistently, CD44 and CD133 were decreased by Berberine treatment
CD133↓,
ChemoSen↑, Berberine Enhanced Chemosensitivity via Regulating FTO


Showing Research Papers: 1 to 2 of 2

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 2

Pathway results for Effect on Cancer / Diseased Cells:


Cell Death ⓘ

Apoptosis↑, 1,   p27↑, 1,  

Cell Cycle & Senescence ⓘ

cycD1/CCND1↓, 1,   P21↑, 1,   TumCCA↑, 1,  

Proliferation, Differentiation & Cell State ⓘ

CD133↓, 1,   CD44↓, 1,   CSCs↓, 1,   TumCG↓, 1,  

Migration ⓘ

FTO↑, 2,   TumCI↓, 1,   TumCMig↓, 1,   TumCP↓, 2,   β-catenin/ZEB1↓, 1,  

Drug Metabolism & Resistance ⓘ

ChemoSen↑, 2,  

Functional Outcomes ⓘ

toxicity↓, 1,  
Total Targets: 16

Pathway results for Effect on Normal Cells:


Total Targets: 0

Scientific Paper Hit Count for: FTO, Fat mass and obesity-associated protein
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:1389  State#:%  Dir#:2
  wNotes=on  sortOrder:rid,rpid

 

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