miR-448 Cancer Research Results

miR-448, microRNA 448: Click to Expand ⟱

Source:

Type:

miR-448miR-448 acts as a tumor suppressor in several cancers, while in a few contexts it may act as an oncogene.
Regulation of Cancer Stemness
-Downregulates pathways that promote self-renewal and CSC maintenance (e.g., Wnt/β-catenin, PI3K/AKT)

Sensitization to Chemotherapy

Low miR-448 expression often correlates with:
-Poor overall survival
-High grade / advanced stage
-Metastasis
-Chemoresistance

Scientific Papers found: Click to Expand⟱

4698-

PTS,

Pterostilbene, a bioactive component of blueberries, suppresses the generation of breast cancer stem cells within tumor microenvironment and metastasis via modulating NF ‐κ B /microRNA 448 circuit

in-vitro,

BC,

MCF7

in-vitro,

BC,

MDA-MB-231

CSCs↓, potential cancer stem cells ( CSC s)/ TAM modulating effects of pterostilbene in breast cancer.
NF-kB↓, Mechanistically, pterostilbene suppressed NFκB, Twist1, vimentin, and increased E-cadherin expression.
Twist↓,
Vim↓,
E-cadherin↑,
miR-448↑, ncreased amount of microRNA 448

Showing Research Papers: 1 to 1 of 1

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

CSCs↓, 1, miR-448↑, 1,

Migration(tgid=13) ⓘ

E-cadherin↑, 1, Twist↓, 1, Vim↓, 1,

Immune & Inflammatory Signaling(tgid=16) ⓘ

NF-kB↓, 1,
Total Targets: 6

Pathway results for Effect on Normal Cells:

Total Targets: 0

Scientific Paper Hit Count for: miR-448, microRNA 448

Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells