antiNeop Cancer Research Results

antiNeop, antineoplastic: Click to Expand ⟱
Source:
Type:
Antineoplastic is a medical term that literally means “against new growth” and is used to describe agents or therapies that prevent, inhibit, or kill cancer cells.
-In oncology, antineoplastic usually implies anticancer activity
Scientific Papers found: Click to Expand⟱
4913- DSF,    Anticancer effects of disulfiram: a systematic review of in vitro, animal, and human studies
- Review, Var, NA
Apoptosis↑, Disulfiram (DSF), as an anti-alcoholic drug, kills the cancer cells by inducing apoptosis
tumCV↑, DSF was associated with enhanced apoptosis and tumor inhibition rates,
eff↑, The greatest anti-tumor activity was observed when DSF was used as combination therapy or as a nanoparticle-encapsulated molecule
toxicity↓, noticeable body weight loss after DSF treatment, which indicated that there was no major toxicity of DSF.
antiNeop↑, antineoplastic activity of DSF was first recorded in 1977
ChemoSen↑, The synergistic effect of Cis, DOX, TMZ, PTX, Gy, and DSF in induced apoptosis was significantly higher than that of DSF or Cis or DOX or TMZ or Gy alone
RadioS↑, Tumor cell growth was significantly inhibited when DSF, chemotherapy, and radiation therapy were used simultaneously, as shown in the examined in vivo studies
OS↑, All three studies show that DSF is safe and seems to prolong survival of cancer patients
ROS↑, Metabolites of DSF chelate with metal ions, leading to alterations in the intracellular levels of metal ions, enhancement of oxidative stress, inhibition of the activities of superoxide dismutase or matrix metalloproteinases,
SOD↓,
MMP1↓,
eff↑, observation that the combination of DSF with metal ions (Cu, Ag) leads to enhanced anticancer effectiveness is in accordance with the observations of in vitro and animal experiments
Half-Life↓, At the pH of 7.4, the half-life of DSF is 1–1.5 min


Showing Research Papers: 1 to 1 of 1

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress ⓘ

ROS↑, 1,   SOD↓, 1,  

Cell Death ⓘ

Apoptosis↑, 1,  

Transcription & Epigenetics ⓘ

tumCV↑, 1,  

Migration ⓘ

MMP1↓, 1,  

Drug Metabolism & Resistance ⓘ

ChemoSen↑, 1,   eff↑, 2,   Half-Life↓, 1,   RadioS↑, 1,  

Functional Outcomes ⓘ

antiNeop↑, 1,   OS↑, 1,   toxicity↓, 1,  
Total Targets: 12

Pathway results for Effect on Normal Cells:


Total Targets: 0

Scientific Paper Hit Count for: antiNeop, antineoplastic
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:1403  State#:%  Dir#:2
  wNotes=on  sortOrder:rid,rpid

 

Home Page