SAL Cancer Research Results

SAL, specific acetylation level: Click to Expand ⟱
Source:
Type: 
Acetylation is the reversible addition of an acetyl group to lysine residues on histones and many non-histone proteins. It is written by histone acetyltransferases (HATs) and erased by histone deacetylases (HDACs).
-Histone acetylation → relaxed chromatin → gene activation
-Deacetylation → compact chromatin → gene repression

Key writers include EP300 and CREBBP; erasers include multiple HDACs.

Acetylation controls:
-Cell cycle (e.g., acetylation of p53, E2F programs)
-Differentiation vs stemness
-DNA damage response
-Immune visibility (antigen presentation genes)
-Metabolic adaptation (acetylation of metabolic enzymes)

Thus, acetylation is a state regulator, not a single pathway switch.

Therapeutic Relevance
HDAC inhibitors exploit acetylation imbalance to:
-Re-activate silenced genes
-Promote differentiation/apoptosis


Scientific Papers found: Click to Expand⟱
4929- PEITC,  PacT,    Phenethyl isothiocyanate and paclitaxel synergistically enhanced apoptosis and alpha-tubulin hyperacetylation in breast cancer cells
- in-vitro, BC, MCF-7 - in-vitro, BC, MDA-MB-231
ChemoSen↑, Combination of phenethyl isothiocyanate (PEITC) and paclitaxel (taxol) has been shown to work synergistically to increase apoptosis and cell cycle arrest in breast cancer cells.
Apoptosis↑,
TumCCA↑,
eff↑, treatment of MCF7 cells with both PEITC and taxol led to a 10.4-fold and 5.96-fold increase in specific acetylation of alpha-tubulin over single agent PEITC and taxol, respectively.
CDK1↓, The combination of PEITC and taxol also reduced expressions of cell cycle regulator Cdk1, and anti-apoptotic protein bcl-2, enhanced expression of Bax and cleavage of PARP proteins.
Bcl-2↓,
BAX↑,
cl‑PARP↑,
SAL↑, PEITC and taxol increased acetylation of alpha-tubulin in breast cancer cells. 16% and 28% respective increase in the specific acetylation level (SAL)


Showing Research Papers: 1 to 1 of 1

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:


Cell Death ⓘ

Apoptosis↑, 1,   BAX↑, 1,   Bcl-2↓, 1,  

DNA Damage & Repair ⓘ

cl‑PARP↑, 1,  

Cell Cycle & Senescence ⓘ

CDK1↓, 1,   TumCCA↑, 1,  

Proliferation, Differentiation & Cell State ⓘ

SAL↑, 1,  

Drug Metabolism & Resistance ⓘ

ChemoSen↑, 1,   eff↑, 1,  
Total Targets: 9

Pathway results for Effect on Normal Cells:


Total Targets: 0

Scientific Paper Hit Count for: SAL, specific acetylation level
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:1414  State#:%  Dir#:2
  wNotes=on  sortOrder:rid,rpid

 

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