miR-194 Cancer Research Results

miR-194, miR-194: Click to Expand ⟱
Source:
Type:
miR-194 is a small, non-coding RNA enriched in epithelial tissues (notably liver, intestine, and kidney). Its physiologic role is to reinforce epithelial differentiation by repressing transcripts that drive motility, EMT, and stemness.
-Commonly DOWNREGULATED in many solid tumors during progression.
-Loss of miR-194 facilitates EMT, invasion, metastasis, and therapy resistance.
miR-194 is a tumor-suppressive microRNA whose loss marks transition toward EMT, invasion, and metastatic competence. As a biomarker, it is best used to interpret tumor state and risk—especially differentiation versus plasticity—rather than to diagnose cancer or choose a specific therapy.br
Scientific Papers found: Click to Expand⟱
4931- PEITC,    Phenethyl isothiocyanate (PEITC) suppresses prostate cancer cell invasion epigenetically through regulating microRNA-194
- in-vitro, Pca, LNCaP - in-vitro, Pca, PC3
Risk↓, The glucosinolate-derived PEITC has been widely documented to reduce the risk of prostate cancer by modulating multiple biologically relevant processes.
miR-194↑, PEITC treatment decreased miR-106a/b and miR-695 levels in LNCaP cells (Fig 1B), whereas miR-194 levels were up-regulated in both the LNCaP and the PC3 cells
TumCI↓, miR-194 suppresses PC3 cell invasiveness in vitro
MMP2↓, PEITC down-regulates MMP2 and MMP9 via miR-194
MMP9↓,
BMP2↓, We found that both miR-194 mimic and PEITC treatments decreased BMP1 expression
*chemoPv↑, In addition, growing evidence has suggested that epigenetic mechanisms, particularly those mediated by miRNAs, are implicated in the chemopreventive effects of PEITC


Showing Research Papers: 1 to 1 of 1

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:


Cell Death ⓘ

BMP2↓, 1,  

Proliferation, Differentiation & Cell State ⓘ

miR-194↑, 1,  

Migration ⓘ

MMP2↓, 1,   MMP9↓, 1,   TumCI↓, 1,  

Functional Outcomes ⓘ

Risk↓, 1,  
Total Targets: 6

Pathway results for Effect on Normal Cells:


Functional Outcomes ⓘ

chemoPv↑, 1,  
Total Targets: 1

Scientific Paper Hit Count for: miR-194, miR-194
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:1415  State#:%  Dir#:2
  wNotes=on  sortOrder:rid,rpid

 

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