chemoPv Cancer Research Results

chemoPv, ChemoPreventive: Click to Expand ⟱
Source:
Type:
Chemopreventive: An agent that lowers the probability of cancer development or delays progression from premalignant states.
Mechanisms
-Reduce DNA damage / mutagenesis
-Enhance detoxification or repair
-Modulate hormones or inflammation
-Promote differentiation or apoptosis of abnormal cells


Scientific Papers found: Click to Expand⟱
4599- AgNPs,  ProBio,    Impacts of dietary silver nanoparticles and probiotic administration on the microbiota of an in-vitro gut model
- in-vivo, Nor, NA
*GutMicro∅, *chemoPv↑,
5168- AL,    Allicin (from garlic) induces caspase-mediated apoptosis in cancer cells
- in-vitro, Var, NA
TumCG↓, Casp3↑, Casp8↑, Casp9↑, chemoPv↑,
2639- Api,    Plant flavone apigenin: An emerging anticancer agent
- Review, Var, NA
*antiOx↑, *Inflam↓, AntiCan↑, ChemoSen↑, BioEnh↑, chemoPv↑, IL6↓, STAT3↓, NF-kB↓, IL8↓, eff↝, Akt↓, PI3K↓, HER2/EBBR2↓, cycD1/CCND1↓, CycD3↓, p27↑, FOXO3↑, STAT3↓, MMP2↓, MMP9↓, VEGF↓, Twist↓, MMP↓, ROS↑, NADPH↑, NRF2↓, SOD↓, COX2↓, p38↑, Telomerase↓, HDAC↓, HDAC1↓, HDAC3↓, Hif1a↓, angioG↓, uPA↓, Ca+2↑, Bax:Bcl2↑, Cyt‑c↑, Casp9↑, Casp12↑, Casp3↑, cl‑PARP↑, E-cadherin↑, β-catenin/ZEB1↓, cMyc↓, CDK4↓, CDK2↓, CDK6↓, IGF-1↓, CK2↓, CSCs↓, FAK↓, Gli↓, GLUT1↓,
2640- Api,    Apigenin: A Promising Molecule for Cancer Prevention
- Review, Var, NA
chemoPv↑, ITGB4↓, TumCI↓, TumMeta↓, Akt↓, ERK↓, p‑JNK↓, *Inflam↓, *PKCδ↓, *MAPK↓, EGFR↓, CK2↓, TumCCA↑, CDK1↓, P53↓, P21↑, Bax:Bcl2↑, Cyt‑c↑, APAF1↑, Casp↑, cl‑PARP↑, VEGF↓, Hif1a↓, IGF-1↓, IGFBP3↑, E-cadherin↑, β-catenin/ZEB1↓, HSPs↓, Telomerase↓, FASN↓, MMPs↓, HER2/EBBR2↓, CK2↓, eff↑, AntiAg↑, eff↑, FAK↓, ROS↑, Bcl-2↓, Cyt‑c↑, cl‑Casp3↑, cl‑Casp7↑, cl‑Casp8↑, cl‑Casp9↑, cl‑IAP2↑, AR↓, PSA↓, p‑pRB↓, p‑GSK‐3β↓, CDK4↓, ChemoSen↑, Ca+2↑, cal2↑,
2596- Api,  LT,    Natural Nrf2 Inhibitors: A Review of Their Potential for Cancer Treatment
- Review, Var, NA
NRF2↓, chemoPv↑, ChemoSen↑,
2584- Api,  Chemo,    The versatility of apigenin: Especially as a chemopreventive agent for cancer
- Review, Var, NA
ChemoSen↑, RadioS↑, eff↝, DR5↑, selectivity↑, angioG↓, selectivity↑, chemoP↑, MAPK↓, PI3K↓, Akt↓, mTOR↓, Wnt↓, β-catenin/ZEB1↓, GLUT1↓, radioP↑, BioAv↓, chemoPv↑,
3166- Ash,    Exploring the Multifaceted Therapeutic Potential of Withaferin A and Its Derivatives
- Review, Var, NA
*p‑PPARγ↓, *cardioP↑, *AMPK↑, *BioAv↝, *Half-Life↝, *Half-Life↝, *Dose↑, *chemoPv↑, IL6↓, STAT3↓, ROS↓, OXPHOS↓, PCNA↓, LDH↓, AMPK↑, TumCCA↑, NOTCH3↓, Akt↓, Bcl-2↓, Casp3↑, Apoptosis↑, eff↑, NF-kB↓, CSCs↓, HSP90↓, PI3K↓, FOXO3↑, β-catenin/ZEB1↓, N-cadherin↓, EMT↓, FASN↓, ACLY↓, ROS↑, NRF2↑, HO-1↑, NQO1↑, JNK↑, mTOR↓, neuroP↑, *TNF-α↓, *IL1β↓, *IL6↓, *IL8↓, *IL18↓, RadioS↑, eff↑,
4814- ASTX,    Chemopreventive and therapeutic efficacy of astaxanthin against cancer: A comprehensive review
- Review, Var, NA
Apoptosis↑, EMT↓, AntiCan↑, *cardioP↑, *neuroP↑, TumCG↓, *antiOx↑, *Bacteria↓, *Imm↑, *hepatoP↑, *AntiDiabetic↑, ROS↓, *chemoPv↑,
5427- ASTX,    Astaxanthin and Cancer Chemoprevention
- Review, Var, NA
chemoP↑, AntiCan↑, chemoPv↑, Risk↓, lipid-P↓, Pain↓, BioAv↑, Dose↝,
147- ATG,  EGCG,  CUR,    Increased chemopreventive effect by combining arctigenin, green tea polyphenol and curcumin in prostate and breast cancer cells
- in-vitro, Pca, LNCaP - in-vitro, Pca, MCF-7
Bax:Bcl2↑, NF-kB↓, PI3K/Akt↓, STAT3↓, chemoPv↑, TumCP↓, TumCCA↑, TumCMig↓,
5179- BBR,    Regulation of Cell Signaling Pathways by Berberine in Different Cancers: Searching for Missing Pieces of an Incomplete Jig-Saw Puzzle for an Effective Cancer Therapy
- Review, Var, NA
AMPK↑, Casp3↑, cl‑PARP↑, Mcl-1↓, cFLIP↓, β-catenin/ZEB1↓, Wnt↓, STAT3↓, mTOR↓, Hif1a↓, NF-kB↓, SIRT1↑, DNMT1↓, DNMT3A↓, miR-29b↓, IGFBP1↑, eff↑, chemoPv↑, BioAv↓,
5631- BCA,    Perspectives Regarding the Role of Biochanin A in Humans
- Review, Var, NA - Review, AD, NA
*BioAv↓, *Inflam↓, AntiCan↑, *neuroP↑, chemoPv↑, Dose↝, *SOD↑, *MDA↓, *BAX↓, *HSP70/HSPA5↑, *AntiDiabetic↑, *Insulin↑, *TNF-α↓, *IL1β↓, *IL6↓, *iNOS↓, *COX2↓, *MMP9↓, *ROS↓, *PGE2↓, *BACE↓, *BioAv↑, P-gp⇅,
5632- BCA,    Pharmacokinetics and bioavailability of the isoflavone biochanin A in rats
- in-vivo, Var, NA
chemoPv↑, *BioAv↓,
5582- BetA,    Targeting mitochondrial apoptosis by betulinic acid in human cancers
- Review, Var, NA
Apoptosis↑, MMP↓, Cyt‑c↑, ROS↑, NF-kB↑, angioG↓, mtDam↑, TOP1↓, selectivity↑, ChemoSen↑, TumCG↓, chemoPv↑, RadioS↑,
2736- BetA,  Chemo,    Multifunctional Roles of Betulinic Acid in Cancer Chemoprevention: Spotlight on JAK/STAT, VEGF, EGF/EGFR, TRAIL/TRAIL-R, AKT/mTOR and Non-Coding RNAs in the Inhibition of Carcinogenesis and Metastasis
- Review, Var, NA
chemoPv↑, p‑STAT3↓, JAK1↓, JAK2↓, VEGF↓, EGFR↓, Cyt‑c↑, Diablo↑, AMPK↑, mTOR↓, Sp1/3/4↓, DNAdam↑, Gli1↓, GLI2↓, PTCH1↓, MMP2↓, MMP9↓, miR-21↓, SOD2↓, ROS↑, Apoptosis↑,
2759- BetA,    Chemopreventive and Chemotherapeutic Potential of Betulin and Betulinic Acid: Mechanistic Insights From In Vitro, In Vivo and Clinical Studies
- Review, Var, NA
chemoPv↑, ChemoSen↑, *Inflam↓, *NRF2↑, *NF-kB↓, *COX2↓, ROS↑, MMP↓, Sp1/3/4↓, VEGF↓,
696- Bor,    Nothing Boring About Boron
- Review, Var, NA
*hs-CRP↓, *TNF-α↓, *SOD↑, *Catalase↑, *GPx↑, *cognitive↑, *memory↑, *Risk↓, *SAM-e↑, *NAD↝, *ATP↝, *Ca+2↝, HDAC↓, TumVol↓, IGF-1↓, PSA↓, Cyc↓, TumCMig↓, *serineP↓, HIF-1↓, *ChemoSideEff↓, *VitD↑, *Mag↑, *eff↑, Risk↓, *Inflam↓, *neuroP↑, *Calcium↑, *BMD↑, *chemoP↑, AntiCan↑, *Dose↑, *Dose↝, *BMPs↑, *testos↑, angioG↓, Apoptosis↑, *selectivity↑, *chemoPv↑,
2767- Bos,    The potential role of boswellic acids in cancer prevention and treatment
- Review, Var, NA
*Inflam↓, AntiCan↑, *MAPK↑, *Ca+2↝, p‑ERK↓, TumCI↓, cycD1/CCND1↓, cycE/CCNE↓, CDK2↓, CDK4↓, p‑RB1↓, *NF-kB↓, *TNF-α↓, NF-kB↓, IKKα↓, MCP1↓, IL1α↓, MIP2↓, VEGF↓, Tf↓, COX2↓, MMP9↓, CXCR4↓, VEGF↓, eff↑, PPARα↓, lipid-P?, STAT3↓, TOP1↓, TOP2↑, 5HT↓, p‑PDGFR-BB↓, PDGF↓, AR↓, DR5↑, angioG↓, DR4↑, Casp3↑, Casp8↑, cl‑PARP↑, eff↑, chemoPv↑, Wnt↓, β-catenin/ZEB1↓, ascitic↓, Let-7↑, miR-200b↑, eff↑, MMP1↓, MMP2↓, eff↑, BioAv↓, BioAv↑, Half-Life↓, toxicity↓, Dose↑, BioAv↑, ChemoSen↑,
5705- Brut,    A flavonoid-rich extract from bergamot juice prevents carcinogenesis in a genetic model of colorectal cancer, the Pirc rat (F344/NTac-Apcam1137)
- in-vivo, CRC, NA
Risk↓, TumMeta↓, Apoptosis↑, COX2↓, iNOS↓, IL1β↓, IL6↓, IL10↓, P53↑, P21↓, survivin↓, chemoPv↑, *Inflam↓,
5745- Buty,    Microbial Oncotarget: Bacterial-Produced Butyrate, Chemoprevention and Warburg Effect
- Review, Var, NA
selectivity↑, HDAC↓, TumCP↓, Apoptosis↑, Warburg↓, chemoPv↑,
5751- CA,    Potential Therapeutic Implications of Caffeic Acid in Cancer Signaling: Past, Present, and Future
- Review, Var, NA
*antiOx↑, *chemoPv↑, ROS↑, MMP2↓, MMP9↓, BioAv↓, eff↑, *Inflam↓, AMPK↑, lipid-P↑, eff↑, ChemoSen↑, *memory↑, *ROS↓,
5868- CA,    Carnosic acid inhibits the proliferation and migration capacity of human colorectal cancer cells
- in-vitro, Colon, Caco-2 - in-vitro, Colon, HT29 - in-vitro, CRC, LoVo
Apoptosis↑, TumCMig↓, uPA↓, MMPs↓, COX2↓, TumCA↓, MMP9↓, MMP2↓, chemoPv↑,
5779- Calc,    Calcium supplementation for the prevention of colorectal adenomas: A systematic review and meta-analysis of randomized controlled trials
- Study, CRC, NA
chemoPv↑,
5842- CAP,    Capsaicin: Current Understanding of Its Mechanisms and Therapy of Pain and Other Pre-Clinical and Clinical Uses
- Review, Nor, NA - Review, Diabetic, NA
*Pain↓, *TRPV1↑, AMPK↑, ROS↑, TumCP↑, Apoptosis↑, TumCCA↑, Casp3↑, BAX↑, Bak↑, cl‑PARP↑, Bcl-2↓, RNS↑, *glucose↓, *Insulin↑, *BP↓, *AntiAg↑, ER Stress↑, Hif1a↓, chemoPv↑,
5833- CAP,    Capsaicin: From Plants to a Cancer-Suppressing Agent
- Review, Var, NA
chemoPv↑, TumCCA↑, Apoptosis↑, ROS↑, MMP↓, Ca+2↑, JNK↑, Casp3↑, NADH↓, CDK2↓, CDK4↓, CDK6↓, P53↑,
5861- CAP,    Anticancer Properties of Capsaicin Against Human Cancer
- Review, Var, NA
*antiOx↑, *Inflam↓, *Obesity↓, chemoPv↑, Apoptosis↑, selectivity↑, TRPV1↑, Ca+2↑, mtDam↑, Cyt‑c↑, P53↑, SIRT1↓, TumCCA↑, P21↑, CDK4↓, CDK6↓, cycE/CCNE↓, angioG↓, TumMeta↓,
5198- CAP,    Capsaicin induces apoptosis by generating reactive oxygen species and disrupting mitochondrial transmembrane potential in human colon cancer cell lines
- in-vitro, CRC, LoVo - in-vitro, CRC, Colo320
tumCV↓, DNAdam↑, Apoptosis↑, ROS↑, MMP↑, Casp3↑, chemoPv↑,
2652- CAP,    Oxidative Stress Inducers in Cancer Therapy: Preclinical and Clinical Evidence
- Review, Var, NA
chemoPv↑, AntiCan↑, ROS↑, TumCG↓, ROS↑, MMP↑, Apoptosis↑, TumCCA↑, JNK↑, SOD↓, Catalase↓, GPx↓, other↓, SIRT1↓, NADPH↑, FOXO3↑,
2019- CAP,    Capsaicin: A Two-Decade Systematic Review of Global Research Output and Recent Advances Against Human Cancer
- Review, Var, NA
chemoPv↑, Ca+2↑, antiOx↑, *ROS↓, *MMP∅, *Cyt‑c∅, *Casp3∅, *eff↑, *Inflam↓, *NF-kB↓, *COX2↓, iNOS↓, TRPV1↑, i-Ca+2?, MMP↓, Cyt‑c↑, Bax:Bcl2↑, P53↑, JNK↑, PI3K↓, Akt↓, mTOR↓, LC3II↑, ATG5↑, p62↑, Fap1↓, Casp3↑, Apoptosis↑, ROS↑, MMP9↓, eff↑, eff↓, eff↑, selectivity↑, eff↑, ChemoSen↑,
5772- CAPE,    The Pluripotent Activities of Caffeic Acid Phenethyl Ester
- Review, Var, NA
*Bacteria↓, *AntiCan↑, *Imm↑, *Wound Healing↑, *NF-kB↓, *5LO↓, *AntiDiabetic↑, ChemoSen↑, selectivity↑, chemoPv↑,
5898- CAR,    Carvacrol-induced apoptosis via tumor suppressor gene activation and oxidative stress modulation in a rat model of breast cancer
- in-vivo, BC, NA
*lipid-P↓, *MDA↓, *antiOx↑, *Inflam↑, RenoP↑, hepatoP↑, *ALAT↓, AST↓, creat↓, chemoPv↑, Cyt‑c↑, FADD↑, P53↑,
5926- CAR,    An Updated Review of Research into Carvacrol and Its Biological Activities
- Review, Nor, NA - Review, AD, NA - Review, asthmatic, NA
*Inflam↓, *antiOx↑, *neuroP↑, *BioAv↑, *toxicity↓, *Pain↓, *TRPV3↑, *NRF2↑, *Ca+2↑, *ATP↑, *5LO↓, *COX2↓, PGE2↓, *hepatoP↑, *AntiAg↑, *Diar↓, *cardioP↑, *other↝, *chemoPv↑, *cognitive↑, *AChE↓, *GastroP↑, *eff↑, *BChE↓, *CRP↓,
5954- CEL,    The molecular mechanisms of celecoxib in tumor development
- Review, Var, NA
TumCP↓, TumCMig↓, TumCI↓, COX2↓, p‑NF-kB↓, Akt↓, MMP2↓, MMP9↓, Apoptosis↑, mitResp↑, ER Stress↑, TumAuto↑, ChemoSen↑, Inflam↓, PGE2↓, chemoPv↑, toxicity↓, Risk↓, PI3K↓, RadioS↑, TumCMig↓, TumCI↓, cJun↓, Sp1/3/4↓, ROS↑, MMP↓, MPT↑, Ca+2↑, Glycolysis↓, ATP↓, CSCs↓, Wnt/(β-catenin)↓, EMT↓, toxicity↝,
2653- Cela,    Oxidative Stress Inducers in Cancer Therapy: Preclinical and Clinical Evidence
- Review, Var, NA
chemoPv↑, Catalase↑, ROS↑, HSP90↓, Sp1/3/4↓, AMPK↑, P53↑, JNK↑, ER Stress↑, MMP↓, TumCCA↑, TumAuto↑, Hif1a↑, Akt↑, other↓, Prx↓,
6016- CGA,    Coffee Chlorogenic Acids Incorporation for Bioactivity Enhancement of Foods: A Review
- Review, Var, NA - Review, AD, NA - Review, Diabetic, NA
antiOx↑, *Bacteria↓, AntiCan↑, *Inflam↓, *cardioP↑, *AntiDiabetic↑, *GutMicro↑, *eff↑, *eff↑, *ROS↓, *IronCh↑, *neuroP↑, *AChE↓, *BChE↓, *chemoPv↑, *BioAv⇅,
6078- CHL,    Update on the bioavailability and chemopreventative mechanisms of dietary chlorophyll derivatives
- Review, Nor, NA
*BioAv↑, chemoPv↑, *ROS↓, eff↑,
6072- CHL,    Low-dose dietary chlorophyll inhibits multi-organ carcinogenesis in the rainbow trout
- in-vivo, Var, NA
AntiCan↑, AntiTum↑, chemoPv↑,
6065- CHL,    Chemoprevention with chlorophyllin in individuals exposed to dietary aflatoxin
- Review, HCC, NA
*eff↑, *chemoPv↑, *other↝,
6085- CHOC,    Epicatechin-rich cocoa polyphenol inhibits Kras-activated pancreatic ductal carcinoma cell growth in vitro and in a mouse model
- in-vivo, PC, NA
selectivity↑, TumCP↓, p‑Akt↓, NF-kB↓, TumCG↓, *BioAv↑, *chemoPv↑,
6084- CHOC,    Cocoa Polyphenols and Their Potential Benefits for Human Health
- Review, Nor, NA - Review, Stroke, NA - Review, IBD, NA
*lipid-P↓, *ROS↓, *Inflam↓, *BP↓, *cardioP↑, *chemoPv↑, *BioAv⇅, *antiOx↑, *Risk↓, *5LO↓, *AntiAg↑, *Imm↑, *NF-kB↓, *other↓, CYP1A1↓, COX2↓, *Obesity↓, *cognitive↑,
6082- CHOC,    Potential for preventive effects of cocoa and cocoa polyphenols in cancer
- Review, Var, NA
*ROS↓, Apoptosis↑, Inflam↓, TumCP↓, angioG↓, TumMeta↓, *Ca+2↓, *MMP∅, CYP1A1↑, PGE2↓, TumCCA↑, chemoPv↑,
2796- CHr,    Chemopreventive effect of chrysin, a dietary flavone against benzo(a)pyrene induced lung carcinogenesis in Swiss albino mice
- in-vivo, Lung, NA
PCNA↓, COX2↓, NF-kB↓, chemoPv↑, *SOD↑, *Catalase↓, *GR↓, *GPx↓, *lipid-P↓, *COX2↓, *NF-kB↓, *ROS↓,
2799- CHr,    Chrysin suppresses renal carcinogenesis via amelioration of hyperproliferation, oxidative stress and inflammation: plausible role of NF-κB
- in-vivo, RCC, NA
*chemoPv↑, *ROS↓, *Inflam↓,
2783- CHr,    Apoptotic Effects of Chrysin in Human Cancer Cell Lines
- Review, Var, NA
TumCP↓, Apoptosis↑, Casp↑, PCNA↓, p38↑, NF-kB↑, DNAdam↑, XIAP↓, Cyt‑c↑, Casp3↑, Akt↓, SCF↓, hTERT/TERT↓, COX2↓, *Inflam↓, *antiOx↑, *chemoPv↑, AR-V7?, CYP19?,
2786- CHr,    Chemopreventive and therapeutic potential of chrysin in cancer: mechanistic perspectives
- Review, Var, NA
Apoptosis↑, TumCCA↑, angioG↓, TumCI↓, TumMeta↑, *toxicity↓, selectivity↑, chemoPv↑, *GSTs↑, *NADPH↑, *GSH↑, HDAC8↓, Hif1a↓, *ROS↓, *NF-kB↓, SCF↓, cl‑PARP↑, survivin↓, XIAP↓, Casp3↑, Casp9↑, GSH↓, ChemoSen↑, Fenton↑, P21↑, P53↑, cycD1/CCND1↓, CDK2↓, STAT3↓, VEGF↓, Akt↓, NRF2↓,
2788- CHr,    Chrysin: Sources, beneficial pharmacological activities, and molecular mechanism of action
- Review, Var, NA
*neuroP↑, *Inflam↓, *ROS↓, NF-kB↓, *PCNA↓, *COX2↓, ChemoSen↑, Hif1a↓, angioG↓, *chemoPv↑, PDGF↓, *memory↑, *RenoP↑, *PPARα↑, *lipidLev↓, *hepatoP↑, *cardioP⇅, *BioAv↓,
4762- CoQ10,    The role of coenzyme Q10 as a preventive and therapeutic agent for the treatment of cancers
- Review, Var, NA
*AntiCan↓, *ROS↓, chemoPv↑, TumCCA↑, Apoptosis↑, TumCP↓, angioG↓, MMPs↓, ChemoSen∅,
5801- CRMs,  Chemo,    Caloric Restriction Enhances Chemotherapy Efficacy and Reshapes Stress Responses in Sarcoma
- in-vivo, sarcoma, NA
TumCG↓, *hepatoP↑, *ROS↓, *OS↑, ChemoSen↑, chemoPv↑, selectivity↑, *DNAdam↓,
161- CUR,  MeSA,    Enhanced apoptotic effects by the combination of curcumin and methylseleninic acid: potential role of Mcl-1 and FAK
- in-vitro, BC, MDA-MB-231 - in-vitro, Pca, DU145
Mcl-1↑, Mcl-1↓, MPT↑, AIF↑, chemoPv↑, Apoptosis↑, ROS↑, FAK↓, STAT3↓, NF-kB↓,
128- CUR,  RES,    Evaluation of biophysical as well as biochemical potential of curcumin and resveratrol during prostate cancer
- in-vivo, Pca, NA
lipid-P↓, chemoPv↑, GSH↑, SOD↑, GSTs↑, glucose↓,

Showing Research Papers: 1 to 50 of 98
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* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 98

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress ⓘ

antiOx↑, 2,   Catalase↓, 1,   Catalase↑, 1,   CYP1A1↓, 1,   CYP1A1↑, 1,   Fenton↑, 1,   GPx↓, 1,   GSH↓, 1,   GSH↑, 1,   GSTs↑, 1,   HO-1↑, 1,   lipid-P?, 1,   lipid-P↓, 2,   lipid-P↑, 1,   NADH↓, 1,   NQO1↑, 1,   NRF2↓, 3,   NRF2↑, 1,   OXPHOS↓, 1,   Prx↓, 1,   RNS↑, 1,   ROS↓, 2,   ROS↑, 16,   SOD↓, 2,   SOD↑, 1,   SOD2↓, 1,  

Metal & Cofactor Biology ⓘ

Tf↓, 1,  

Mitochondria & Bioenergetics ⓘ

AIF↑, 1,   ATP↓, 1,   mitResp↑, 1,   MMP↓, 7,   MMP↑, 2,   MPT↑, 2,   mtDam↑, 2,   XIAP↓, 2,  

Core Metabolism/Glycolysis ⓘ

ACLY↓, 1,   AMPK↑, 6,   cMyc↓, 1,   FASN↓, 2,   glucose↓, 1,   Glycolysis↓, 1,   LDH↓, 1,   NADPH↑, 2,   PI3K/Akt↓, 1,   PPARα↓, 1,   SIRT1↓, 2,   SIRT1↑, 1,   Warburg↓, 1,  

Cell Death ⓘ

Akt↓, 8,   Akt↑, 1,   p‑Akt↓, 1,   APAF1↑, 1,   Apoptosis↑, 20,   Bak↑, 1,   BAX↑, 1,   Bax:Bcl2↑, 4,   Bcl-2↓, 3,   Casp↑, 2,   Casp12↑, 1,   Casp3↑, 11,   cl‑Casp3↑, 1,   cl‑Casp7↑, 1,   Casp8↑, 2,   cl‑Casp8↑, 1,   Casp9↑, 3,   cl‑Casp9↑, 1,   cFLIP↓, 1,   CK2↓, 3,   Cyt‑c↑, 9,   Diablo↑, 1,   DR4↑, 1,   DR5↑, 2,   FADD↑, 1,   Fap1↓, 1,   hTERT/TERT↓, 1,   cl‑IAP2↑, 1,   iNOS↓, 2,   JNK↑, 5,   p‑JNK↓, 1,   MAPK↓, 1,   Mcl-1↓, 2,   Mcl-1↑, 1,   p27↑, 1,   p38↑, 2,   survivin↓, 2,   Telomerase↓, 2,   TRPV1↑, 2,  

Kinase & Signal Transduction ⓘ

HER2/EBBR2↓, 2,   Sp1/3/4↓, 4,  

Transcription & Epigenetics ⓘ

cJun↓, 1,   miR-21↓, 1,   other↓, 2,   p‑pRB↓, 1,   tumCV↓, 1,  

Protein Folding & ER Stress ⓘ

ER Stress↑, 3,   HSP90↓, 2,   HSPs↓, 1,  

Autophagy & Lysosomes ⓘ

ATG5↑, 1,   LC3II↑, 1,   p62↑, 1,   TumAuto↑, 2,  

DNA Damage & Repair ⓘ

DNAdam↑, 3,   DNMT1↓, 1,   DNMT3A↓, 1,   P53↓, 1,   P53↑, 7,   cl‑PARP↑, 6,   PCNA↓, 3,  

Cell Cycle & Senescence ⓘ

CDK1↓, 1,   CDK2↓, 4,   CDK4↓, 5,   Cyc↓, 1,   cycD1/CCND1↓, 3,   CycD3↓, 1,   cycE/CCNE↓, 2,   P21↓, 1,   P21↑, 3,   p‑RB1↓, 1,   TumCCA↑, 11,  

Proliferation, Differentiation & Cell State ⓘ

AR-V7?, 1,   CSCs↓, 3,   EMT↓, 3,   ERK↓, 1,   p‑ERK↓, 1,   FOXO3↑, 3,   Gli↓, 1,   Gli1↓, 1,   p‑GSK‐3β↓, 1,   HDAC↓, 3,   HDAC1↓, 1,   HDAC3↓, 1,   HDAC8↓, 1,   IGF-1↓, 3,   IGFBP1↑, 1,   IGFBP3↑, 1,   Let-7↑, 1,   mTOR↓, 5,   NOTCH3↓, 1,   PI3K↓, 5,   PTCH1↓, 1,   SCF↓, 2,   STAT3↓, 8,   p‑STAT3↓, 1,   TOP1↓, 2,   TOP2↑, 1,   TumCG↓, 6,   Wnt↓, 3,   Wnt/(β-catenin)↓, 1,  

Migration ⓘ

AntiAg↑, 1,   Ca+2↑, 6,   i-Ca+2?, 1,   cal2↑, 1,   E-cadherin↑, 2,   FAK↓, 3,   GLI2↓, 1,   ITGB4↓, 1,   miR-200b↑, 1,   miR-29b↓, 1,   MMP1↓, 1,   MMP2↓, 6,   MMP9↓, 7,   MMPs↓, 3,   N-cadherin↓, 1,   PDGF↓, 2,   TumCA↓, 1,   TumCI↓, 5,   TumCMig↓, 5,   TumCP↓, 7,   TumCP↑, 1,   TumMeta↓, 4,   TumMeta↑, 1,   Twist↓, 1,   uPA↓, 2,   β-catenin/ZEB1↓, 6,  

Angiogenesis & Vasculature ⓘ

angioG↓, 10,   EGFR↓, 2,   HIF-1↓, 1,   Hif1a↓, 6,   Hif1a↑, 1,   p‑PDGFR-BB↓, 1,   VEGF↓, 7,  

Barriers & Transport ⓘ

GLUT1↓, 2,   P-gp⇅, 1,  

Immune & Inflammatory Signaling ⓘ

COX2↓, 8,   CXCR4↓, 1,   IKKα↓, 1,   IL10↓, 1,   IL1α↓, 1,   IL1β↓, 1,   IL6↓, 3,   IL8↓, 1,   Inflam↓, 2,   JAK1↓, 1,   JAK2↓, 1,   MCP1↓, 1,   MIP2↓, 1,   NF-kB↓, 9,   NF-kB↑, 2,   p‑NF-kB↓, 1,   PGE2↓, 3,   PSA↓, 2,  

Synaptic & Neurotransmission ⓘ

5HT↓, 1,  

Hormonal & Nuclear Receptors ⓘ

AR↓, 2,   CDK6↓, 3,   CYP19?, 1,  

Drug Metabolism & Resistance ⓘ

BioAv↓, 4,   BioAv↑, 3,   BioEnh↑, 1,   ChemoSen↑, 14,   ChemoSen∅, 1,   Dose↑, 1,   Dose↝, 2,   eff↓, 1,   eff↑, 15,   eff↝, 2,   Half-Life↓, 1,   RadioS↑, 4,   selectivity↑, 10,  

Clinical Biomarkers ⓘ

AR↓, 2,   ascitic↓, 1,   AST↓, 1,   creat↓, 1,   EGFR↓, 2,   HER2/EBBR2↓, 2,   hTERT/TERT↓, 1,   IL6↓, 3,   LDH↓, 1,   PSA↓, 2,  

Functional Outcomes ⓘ

AntiCan↑, 9,   AntiTum↑, 1,   chemoP↑, 2,   chemoPv↑, 37,   hepatoP↑, 1,   neuroP↑, 1,   Pain↓, 1,   radioP↑, 1,   RenoP↑, 1,   Risk↓, 4,   toxicity↓, 2,   toxicity↝, 1,   TumVol↓, 1,  
Total Targets: 241

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress ⓘ

antiOx↑, 8,   Catalase↓, 1,   Catalase↑, 1,   GPx↓, 1,   GPx↑, 1,   GSH↑, 1,   GSTs↑, 1,   lipid-P↓, 3,   MDA↓, 2,   NRF2↑, 2,   ROS↓, 13,   SAM-e↑, 1,   SOD↑, 3,  

Metal & Cofactor Biology ⓘ

IronCh↑, 1,  

Mitochondria & Bioenergetics ⓘ

ATP↑, 1,   ATP↝, 1,   Insulin↑, 2,   MMP∅, 2,  

Core Metabolism/Glycolysis ⓘ

ALAT↓, 1,   AMPK↑, 1,   glucose↓, 1,   lipidLev↓, 1,   NAD↝, 1,   NADPH↑, 1,   PPARα↑, 1,   p‑PPARγ↓, 1,  

Cell Death ⓘ

BAX↓, 1,   Casp3∅, 1,   Cyt‑c∅, 1,   iNOS↓, 1,   MAPK↓, 1,   MAPK↑, 1,   TRPV1↑, 1,  

Kinase & Signal Transduction ⓘ

TRPV3↑, 1,  

Transcription & Epigenetics ⓘ

other↓, 1,   other↝, 2,  

Protein Folding & ER Stress ⓘ

HSP70/HSPA5↑, 1,  

DNA Damage & Repair ⓘ

DNAdam↓, 1,   PCNA↓, 1,  

Migration ⓘ

5LO↓, 3,   AntiAg↑, 3,   Ca+2↓, 1,   Ca+2↑, 1,   Ca+2↝, 2,   MMP9↓, 1,   PKCδ↓, 1,   serineP↓, 1,  

Barriers & Transport ⓘ

GastroP↑, 1,  

Immune & Inflammatory Signaling ⓘ

COX2↓, 6,   CRP↓, 1,   IL18↓, 1,   IL1β↓, 2,   IL6↓, 2,   IL8↓, 1,   Imm↑, 3,   Inflam↓, 16,   Inflam↑, 1,   NF-kB↓, 7,   PGE2↓, 1,   TNF-α↓, 4,   VitD↑, 1,  

Synaptic & Neurotransmission ⓘ

AChE↓, 2,   BChE↓, 2,  

Protein Aggregation ⓘ

BACE↓, 1,  

Hormonal & Nuclear Receptors ⓘ

GR↓, 1,   testos↑, 1,  

Drug Metabolism & Resistance ⓘ

BioAv↓, 3,   BioAv↑, 4,   BioAv⇅, 2,   BioAv↝, 1,   Dose↑, 2,   Dose↝, 1,   eff↑, 6,   Half-Life↝, 2,   selectivity↑, 1,  

Clinical Biomarkers ⓘ

ALAT↓, 1,   BMD↑, 1,   BMPs↑, 1,   BP↓, 2,   Calcium↑, 1,   CRP↓, 1,   GutMicro↑, 1,   GutMicro∅, 1,   hs-CRP↓, 1,   IL6↓, 2,   Mag↑, 1,   VitD↑, 1,  

Functional Outcomes ⓘ

AntiCan↓, 1,   AntiCan↑, 1,   AntiDiabetic↑, 4,   cardioP↑, 5,   cardioP⇅, 1,   chemoP↑, 1,   chemoPv↑, 13,   ChemoSideEff↓, 1,   cognitive↑, 3,   hepatoP↑, 4,   memory↑, 3,   neuroP↑, 6,   Obesity↓, 2,   OS↑, 1,   Pain↓, 2,   RenoP↑, 1,   Risk↓, 2,   toxicity↓, 2,   Wound Healing↑, 1,  

Infection & Microbiome ⓘ

Bacteria↓, 3,   Diar↓, 1,  
Total Targets: 108

Scientific Paper Hit Count for: chemoPv, ChemoPreventive
8 Curcumin
7 Phenethyl isothiocyanate
6 Capsaicin
6 Resveratrol
6 Quercetin
5 Chemotherapy
5 Chrysin
5 Sulforaphane (mainly Broccoli)
4 Apigenin (mainly Parsley)
4 Thymoquinone
3 EGCG (Epigallocatechin Gallate)
3 Betulinic acid
3 Chlorophyllin
3 Chocolate
2 Astaxanthin
2 Arctigenin
2 Biochanin A
2 Carvacrol
2 Genistein (soy isoflavone)
1 Silver-NanoParticles
1 probiotics
1 Allicin (mainly Garlic)
1 Luteolin
1 Ashwagandha(Withaferin A)
1 Berberine
1 Boron
1 Boswellia (frankincense)
1 Bruteridin(bergamot juice)
1 Butyrate
1 Caffeic acid
1 Carnosic acid
1 Calcium
1 Caffeic Acid Phenethyl Ester (CAPE)
1 Celecoxib
1 Celastrol
1 Chlorogenic acid
1 Coenzyme Q10
1 Calorie Restriction Mimetics
1 methylseleninic acid
1 Fisetin
1 Graviola
1 Honokiol
1 Juglone
1 Nimbolide
1 Oleuropein
1 Psoralidin
1 Selenium
1 Selenium NanoParticles
1 Silymarin (Milk Thistle) silibinin
1 Shikonin
1 Selenite (Sodium)
1 Sutherlandioside D
1 Ursolic acid
1 Vitamin C (Ascorbic Acid)
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:1417  State#:%  Dir#:2
  wNotes=0  sortOrder:rid,rpid

 

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