GH Cancer Research Results

GH, Growth Hormone: Click to Expand ⟱
Source:
Type:
GH is secreted by the pituitary and also produced locally by many tumors (autocrine/paracrine GH).
Growth hormone signaling is pro-oncogenic when chronically elevated or locally produced by tumors, acting mainly through:
-IGF-1 → PI3K–AKT–mTOR
-JAK2–STAT5
-Angiogenesis and EMT support
It functions as a metabolic growth amplifier, especially in insulin-resistant and obesity-linked cancers.

Interventions (context-dependent):
-Caloric restriction / fasting
-Insulin sensitivity improvement
-mTOR / IGF-1R pathway inhibition (oncology settings)


Scientific Papers found: Click to Expand⟱
5231- Ex,    Regular Physical Exercise Increase Of Growth Hormone (GH) And Insulin-Like Growth Factor-1 (IGF-1) Activity in Elderly Improve the Aging Process and Quality of Life: A Mini Review
- Human, Nor, NA
*GH↑, Exercise, sleep, food intake, stress, and body composition are all stimuli and inhibitors that affect the hypothalamic components that govern GH production
*IGF-1↑, eight weeks of supervised aerobic exercise instruction resulted in a considerable rise in insulin-like growth factor

7069- GABA,    United States Pharmacopeia (USP) Safety Review of Gamma-Aminobutyric Acid (GABA)
- Review, Nor, NA
*toxicity↓, Data showed no serious adverse events associated with GABA at intakes up to 18 g/d for 4 days and in longer studies at intakes of 120 mg/d for 12 weeks.
*BP↓, GABA was associated with a transient and moderate drop in blood pressure (<10% change). intake of 80 mg/day of GABA was associated with a significant reduction of the BP in adults with mild hypertension, and no adverse effects were reported.
*AntiDiabetic↑, other biological activities, which include anti-hypertension, anti-diabetes, anti-cancer, antioxidant, anti-inflammation, anti-microbial, and anti-allergy effects
*AntiCan↑,
*antiOx↑,
*Inflam↓,
*AntiBio↑,
*other↝, GABA is a popular ingredient in sports dietary supplements and other wellness dietary supplements.
*cognitive↑, The NNHPD monograph for Cognitive Function Products recommends a daily intake of 50–3000 mg GABA that does not exceed 750 mg per single dose; it also says to consult a healthcare practitioner for use of products providing 300 mg/day or more when GABA
*GH↑, GABA has been reported to increase serum GH levels and has been considered an ergogenic aid. Many sports supplements include GABA as an ingredient.
*Sleep↑, insomnia improved more with 300 mg of GABA compared to 150 mg
*BioAv↑, GABA was rapidly absorbed (Tmax: 0.5~1 h)
*Half-Life↝, with a half-life of 5 h.
*BBB↓, very low amounts of GABA cross from the plasma into the brain through the BBB even when GABA is exogenously administered orally or intravenously
*eff↑, GABA and L-theanine had a synergistic effect on the sleep behavior of mice


Showing Research Papers: 1 to 2 of 2

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 2

Pathway results for Effect on Cancer / Diseased Cells:


Total Targets: 0

Pathway results for Effect on Normal Cells:


NA, unassigned(tgid=0) ⓘ

AntiBio↑, 1,  

Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↑, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

other↝, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

GH↑, 2,   IGF-1↑, 1,  

Barriers & Transport(tgid=15) ⓘ

BBB↓, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

Inflam↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↑, 1,   eff↑, 1,   Half-Life↝, 1,  

Clinical Biomarkers(tgid=22) ⓘ

BP↓, 1,  

Functional Outcomes(tgid=23) ⓘ

AntiCan↑, 1,   AntiDiabetic↑, 1,   cognitive↑, 1,   Sleep↑, 1,   toxicity↓, 1,  
Total Targets: 16

Scientific Paper Hit Count for: GH, Growth Hormone
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:1426  State#:%  Dir#:2
  wNotes=on  sortOrder:rid,rpid

 

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