VGSC Cancer Research Results

VGSC, VGNC, Na+ voltage-gated channel: Click to Expand ⟱
Source:
Type:
Voltage-gated sodium channels (VGSCs or VGNCs) (Na+ voltage-gated channel)
-aberrant expression of VGSCs occurs in many cancers, where they contribute to invasion, metastasis, and tumor aggressiveness rather than electrical signaling.
-In most cancers studied to date, voltage-gated sodium channels (VGSCs) are upregulated and hyperactive compared with normal tissue.
-Blocking VGSCs consistently reduces metastasis behaviors
Scientific Papers found: Click to Expand⟱
5520- EP,    Nanosecond Pulsed Electric Field (nsPEF): Opening the Biotechnological Pandora’s Box
- Review, Var, NA
Ca+2↑, leading to an incremental increase in cytoplasmic Ca2+ concentration,
Apoptosis↑, from apoptosis up to cell differentiation and proliferation.
Diff↑,
TumCP↓,
Wound Healing↑, sterilization in the food industry, seed germination, anti-parasitic effects, wound healing, increased immune response
CellMemb↑, available evidence suggest that the increase in cytoplasmic Ca2+ concentration produced by the application of nsPEF could be due to the formation of membrane nanopores.
VGCC↑, most probable cause should be the increase of intracellular Ca2+ concentration via VGCC activation [185].
VGSC↑, findings relating VGNC activation by nsPEF are exciting and deserve more attention.
DNAdam↑, Stacey et al. in 2002 demonstrated that exposing cancer cells to nsPEF with 60 kV/cm could induce DNA damage [243]
selectivity↑, More importantly for nsPEF as cancer treatment, tumor cells are more sensitive to nsPEF than normal cells [246].

5534- MF,    Targeted Osmotic Lysis of Highly Invasive Breast Carcinomas Using Pulsed Magnetic Field Stimulation of Voltage-Gated Sodium Channels and Pharmacological Blockade of Sodium Pumps
- vitro+vivo, BC, MDA-MB-231 - in-vitro, Nor, MCF10
TumVol↓, In vivo, 30 min of PMF stimulation of MDA-MB-231 xenografts in J/Nu mice or 4T1 homografts in BALB/c mice, concurrently treated with 7 mg/kg digoxin reduced tumor size by 60–100%
VGSC↑, data presented is evidence that the PMFs to activate VGSCs in TOL provide sufficient energy to lyse highly malignant cells in vitro and to reduce tumor growth of highly malignant grafts
OS↑, and improve host survival in vivo
selectivity↑, without compromising noncancerous tissues. Using the 80 mT stimulus and 500 nM digoxin concentration, TOL had no effect on MCF-10a cells
eff↑, The MDA-MB-231 cells had been previously shown to express VGSC protein about 7.5-fold greater than “normal” MCF-10a cells

5535- MFrot,    Spatiotemporal magnetic fields enhance cytosolic Ca2+ levels and induce actin polymerization via activation of voltage-gated sodium channels in skeletal muscle cells
- in-vitro, Nor, NA
*Dose↝, We used complex spatiotemporal magnetic fields (17–70 mT) to control intracellular signaling in skeletal muscle cells
*Vm/CMP↑, By changing different parameters of the alternating magnetic field (amplitude, inversion time, rotation frequency), we induced transient depolarization of cellular membranes
*Na+↑, leading to i) Na+ influx through voltage-gated sodium channels (VGSC), ii) cytosolic calcium increase, and iii) VGSC- and ryanodine receptor-dependent increase of actin polymerization.
*VGSC↑, ion fluxes occurred only, when the field was applied and returned to baseline after the field was turned off.
*Vm/CMP↑, mediates a local change in the membrane potential triggering the activation of VGSC.


Showing Research Papers: 1 to 3 of 3

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 3

Pathway results for Effect on Cancer / Diseased Cells:


Cell Death ⓘ

Apoptosis↑, 1,  

DNA Damage & Repair ⓘ

DNAdam↑, 1,  

Proliferation, Differentiation & Cell State ⓘ

Diff↑, 1,   VGCC↑, 1,   VGSC↑, 2,  

Migration ⓘ

Ca+2↑, 1,   TumCP↓, 1,  

Barriers & Transport ⓘ

CellMemb↑, 1,  

Drug Metabolism & Resistance ⓘ

eff↑, 1,   selectivity↑, 2,  

Functional Outcomes ⓘ

OS↑, 1,   TumVol↓, 1,   Wound Healing↑, 1,  
Total Targets: 13

Pathway results for Effect on Normal Cells:


Proliferation, Differentiation & Cell State ⓘ

VGSC↑, 1,  

Migration ⓘ

Na+↑, 1,  

Barriers & Transport ⓘ

Na+↑, 1,   Vm/CMP↑, 2,  

Drug Metabolism & Resistance ⓘ

Dose↝, 1,  
Total Targets: 5

Scientific Paper Hit Count for: VGSC, VGNC, Na+ voltage-gated channel
1 Electrical Pulses
1 Magnetic Fields
1 Magnetic Field Rotating
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:1451  State#:%  Dir#:2
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