Na+ Cancer Research Results

Na+, Sodium ion: Click to Expand ⟱
Source:
Type:
Na+, Sodium Ion -Na⁺ influx enhances metastatic potential.
-VGSC activation → Na⁺ influx
-Na⁺ entry alters cell membrane potential.(Vm)
-in cancer: VGSC expression: ↑ upregulated
-in cancer: Na⁺ influx: ↑ increased
Na⁺ gradients support several transporters:
Transporter	             Effect
Na⁺/H⁺ exchanger (NHE1)	     extracellular acidification
Na⁺/Ca²⁺ exchanger	     Ca²⁺ signaling
Na⁺/glucose cotransporter    metabolic adaptation
-Sodium channel blockers can reduce metastasis in models.
Scientific Papers found: Click to Expand⟱
5859- CAP,    Are We Ready to Recommend Capsaicin for Disorders Other Than Neuropathic Pain?
- Review, Var, NA
*TRPV1↑, the absorbed capsaicin activates its receptor TRPV1, which causes the rapid influx of sodium ions (Na+) and calcium (Ca2+) from the extracellular environment to the cell interior.
*Ca+2↑,
*Na+↑,
*UCPs↑, by increasing thermogenic gene expression such as uncoupling protein 1 (UCP-1), Sirtuin 1 (SIRT-1) [25] and peroxisome proliferator-activated receptor -γ (PPARγ) coactivator 1α (PGC-1α)
*SIRT1↑,
*PPARγ↑,
*Inflam↓, suppressing inflammatory responses, increasing lipid oxidation, inhibiting adipogenesis
*lipid-P↑,
*IL6↓, decreasing the expression of inflammatory biomarkers such as IL-6, TNF, and CCL-2, associated with NF-κB inactivation
*TNF-α↓,
*NF-kB↓,
*p‑Akt↑, Phosphorylation of Akt is also described after capsaicin treatment, which results in disruption of the NRF2/Keap complex and release of activated transcription factor NRF2
*NRF2↑,
*HO-1↑, triggers the transcription of heme-oxygenase1 genes, which are essential for heme degradation and prevention of oxidative damage
*ROS↑,
*GutMicro↑, It is suggested that regular treatment with capsaicin increases diversity in the gut microbiota and abundance of short-chain fatty acid (SCFA)-producing bacteria

5535- MFrot,    Spatiotemporal magnetic fields enhance cytosolic Ca2+ levels and induce actin polymerization via activation of voltage-gated sodium channels in skeletal muscle cells
- in-vitro, Nor, NA
*Dose↝, We used complex spatiotemporal magnetic fields (17–70 mT) to control intracellular signaling in skeletal muscle cells
*Vm/CMP↑, By changing different parameters of the alternating magnetic field (amplitude, inversion time, rotation frequency), we induced transient depolarization of cellular membranes
*Na+↑, leading to i) Na+ influx through voltage-gated sodium channels (VGSC), ii) cytosolic calcium increase, and iii) VGSC- and ryanodine receptor-dependent increase of actin polymerization.
*VGSC↑, ion fluxes occurred only, when the field was applied and returned to baseline after the field was turned off.
*Vm/CMP↑, mediates a local change in the membrane potential triggering the activation of VGSC.

5608- NaHCO3,    Sodium Bicarbonate Nanoparticles for Amplified Cancer Immunotherapy by Inducing Pyroptosis and Regulating Lactic Acid Metabolism
- Study, Var, NA
TumCG↓, Collectively, NaHCO3 NPs observably inhibit primary/distal tumor growth and tumor metastasis through acid neutralization remitted immunosuppression and pyroptosis induced immune activation
TumMeta↓,
e-pH↑,
Pyro↑,
Imm↑,
Na+↑, t can further release high amounts of Na+ ions inside tumor cells


Showing Research Papers: 1 to 3 of 3

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 3

Pathway results for Effect on Cancer / Diseased Cells:


Cell Death ⓘ

Pyro↑, 1,  

Proliferation, Differentiation & Cell State ⓘ

TumCG↓, 1,  

Migration ⓘ

Na+↑, 1,   TumMeta↓, 1,  

Barriers & Transport ⓘ

Na+↑, 1,  

Immune & Inflammatory Signaling ⓘ

Imm↑, 1,  

Cellular Microenvironment ⓘ

e-pH↑, 1,  
Total Targets: 7

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress ⓘ

HO-1↑, 1,   lipid-P↑, 1,   NRF2↑, 1,   ROS↑, 1,   UCPs↑, 1,  

Core Metabolism/Glycolysis ⓘ

PPARγ↑, 1,   SIRT1↑, 1,  

Cell Death ⓘ

p‑Akt↑, 1,   TRPV1↑, 1,  

Proliferation, Differentiation & Cell State ⓘ

VGSC↑, 1,  

Migration ⓘ

Ca+2↑, 1,   Na+↑, 2,  

Barriers & Transport ⓘ

Na+↑, 2,   Vm/CMP↑, 2,  

Immune & Inflammatory Signaling ⓘ

IL6↓, 1,   Inflam↓, 1,   NF-kB↓, 1,   TNF-α↓, 1,  

Drug Metabolism & Resistance ⓘ

Dose↝, 1,  

Clinical Biomarkers ⓘ

GutMicro↑, 1,   IL6↓, 1,  
Total Targets: 21

Scientific Paper Hit Count for: Na+, Sodium ion
1 Capsaicin
1 Magnetic Field Rotating
1 Bicarbonate(Sodium)
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:1452  State#:%  Dir#:2
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