TRPV3 Cancer Research Results

TRPV3, TRPV3: Click to Expand ⟱
Source:
Type:

TRPV3 (Transient Receptor Potential Vanilloid 3) is a calcium-permeable TRP channel involved in epithelial signaling, stress responses, and growth regulation. In cancer, its role appears tumor-type dependent rather than uniform. In several reported cancers, including breast, lung, melanoma, and squamous malignancies, increased TRPV3 expression has been associated with proliferation, survival, invasion, and pro-growth signaling such as ERK/MAPK. In contrast, in colorectal cancer, lower TRPV3 expression has been linked to poorer prognosis, and experimental restoration of TRPV3 has been reported to suppress proliferation and migration, suggesting a tumor-suppressive role in that setting. Overall, TRPV3 is best classified as a context-dependent calcium-signaling regulator whose significance depends on tissue type and downstream signaling environment.
Scientific Papers found: Click to Expand⟱
5927- CAR,    Neuroprotective Potential and Underlying Pharmacological Mechanism of Carvacrol for Alzheimer’s and Parkinson’s Diseases
- Review, AD, NA - Review, Park, NA
*memory↑, *cognitive↑, *ROS↓, *Inflam↓, *motorD↑, *toxicity↓, *TRPV3↑, *other↓, *antiOx↑, *LDL↓, *COX2↓, *PPARα↑, *NO↓, *AChE↓, *eff↑, *SOD↑, *Catalase↑, *neuroP↑, *BioAv↝, *BBB↑, *BioAv↑,
5926- CAR,    An Updated Review of Research into Carvacrol and Its Biological Activities
- Review, Nor, NA - Review, AD, NA - Review, asthmatic, NA
*Inflam↓, *antiOx↑, *neuroP↑, *BioAv↑, *toxicity↓, *Pain↓, *TRPV3↑, *NRF2↑, *Ca+2↑, *ATP↑, *5LO↓, *COX2↓, PGE2↓, *hepatoP↑, *AntiAg↑, *Diar↓, *cardioP↑, *other↝, *chemoPv↑, *cognitive↑, *AChE↓, *GastroP↑, *eff↑, *BChE↓, *CRP↓,

Showing Research Papers: 1 to 2 of 2

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 2

Pathway results for Effect on Cancer / Diseased Cells:


Immune & Inflammatory Signaling ⓘ

PGE2↓, 1,  
Total Targets: 1

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress ⓘ

antiOx↑, 2,   Catalase↑, 1,   NRF2↑, 1,   ROS↓, 1,   SOD↑, 1,  

Mitochondria & Bioenergetics ⓘ

ATP↑, 1,  

Core Metabolism/Glycolysis ⓘ

LDL↓, 1,   PPARα↑, 1,  

Kinase & Signal Transduction ⓘ

TRPV3↑, 2,  

Transcription & Epigenetics ⓘ

other↓, 1,   other↝, 1,  

Migration ⓘ

5LO↓, 1,   AntiAg↑, 1,   Ca+2↑, 1,  

Angiogenesis & Vasculature ⓘ

NO↓, 1,  

Barriers & Transport ⓘ

BBB↑, 1,   GastroP↑, 1,  

Immune & Inflammatory Signaling ⓘ

COX2↓, 2,   CRP↓, 1,   Inflam↓, 2,  

Synaptic & Neurotransmission ⓘ

AChE↓, 2,   BChE↓, 1,  

Drug Metabolism & Resistance ⓘ

BioAv↑, 2,   BioAv↝, 1,   eff↑, 2,  

Clinical Biomarkers ⓘ

CRP↓, 1,  

Functional Outcomes ⓘ

cardioP↑, 1,   chemoPv↑, 1,   cognitive↑, 2,   hepatoP↑, 1,   memory↑, 1,   motorD↑, 1,   neuroP↑, 2,   Pain↓, 1,   toxicity↓, 2,  

Infection & Microbiome ⓘ

Diar↓, 1,  
Total Targets: 36

Scientific Paper Hit Count for: TRPV3, TRPV3
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:1461  State#:%  Dir#:2
  wNotes=0  sortOrder:rid,rpid

 

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