IL15 Cancer Research Results

IL15, Interleukin-15: Click to Expand ⟱
Source:
Type:

Interleukin-15 (IL-15) is generally viewed as an antitumor immune-support cytokine in cancer because it promotes the development, activation, and persistence of NK cells, cytotoxic CD8+ T cells, and memory T cells, thereby strengthening immune-mediated tumor killing. In preclinical and early clinical immunotherapy settings, IL-15 and IL-15-based agonists have been associated with increased cytotoxic lymphocyte activity and reduced tumor growth, and they are being explored in combination with checkpoint blockade, NK-cell therapy, and other immune-based strategies. However, IL-15 is context-dependent rather than uniformly beneficial, because aberrant IL-15 signaling can also support the survival or progression of some hematologic malignancies, so its net effect depends on tumor type, cellular context, and mode of delivery.
Scientific Papers found: Click to Expand⟱
5986- Chit,    The natural product chitosan enhances the anti-tumor activity of natural killer cells by activating dendritic cells
- Study, Var, NA
NK cell↑, In this study, we discovered that chitosan enhanced the anti-tumor activity of natural killer (NK) cells by activating dendritic cells (DCs).
IFN-γ↑, In the presence of DCs, chitosan augmented IFN-γ production by human NK cells.
IL12↑, Mechanistically, chitosan activated DCs to express pro-inflammatory cytokines such as interleukin (IL)-12 and IL-15, which in turn activated the STAT4 and NF-κB signaling pathways, respectively, in NK cells.
IL15↑,
STAT4↑,
NF-kB↑, in NK cells
DCells↑, Collectively, our results demonstrate that chitosan activates DCs leading to enhanced capacity for immune surveillance by NK cells.


Showing Research Papers: 1 to 1 of 1

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:


Proliferation, Differentiation & Cell State ⓘ

STAT4↑, 1,  

Immune & Inflammatory Signaling ⓘ

DCells↑, 1,   IFN-γ↑, 1,   IL12↑, 1,   IL15↑, 1,   NF-kB↑, 1,   NK cell↑, 1,  
Total Targets: 7

Pathway results for Effect on Normal Cells:


Total Targets: 0

Scientific Paper Hit Count for: IL15, Interleukin-15
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:1466  State#:%  Dir#:2
  wNotes=on  sortOrder:rid,rpid

 

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