TRPA1 Cancer Research Results

TRPA1, Transient Receptor Potential Ankyrin 1: Click to Expand ⟱
Source:
Type:

Transient Receptor Potential Ankyrin 1, a Ca²⁺-permeable, nonselective cation channel. It is best known as a sensory “irritant/pain” receptor activated by electrophilic/pungent compounds such as allyl isothiocyanate, allicin, cinnamaldehyde, eugenol, and some cannabinoids.

TRPA1 is biphasic/context-dependent in cancer.

Strategy Possible Effect Concern
TRPA1 inhibition May reduce oxidative-stress tolerance and improve chemosensitivity. Most compelling for breast/lung spheroid-type ROS-defense model.
TRPA1 activation In some models, strong activation causes Ca2+ overload, mitochondrial dysfunction, and apoptosis. Could also promote survival if activation is moderate or coupled to Ca2+ extrusion mechanisms.
Natural TRPA1 agonists Could be anticancer in some contexts. Could theoretically support survival in TRPA1-dependent cancers if dose/exposure creates adaptive Ca2+ signaling rather than overload.


Compound/Product TRPA1 Relationship Database Note
Allicin / Garlic TRPA1 agonist(activated) Strong overlap; garlic organosulfur compounds are classic TRPA1 activators.
Allyl isothiocyanate / Mustard / Wasabi / Crucifers Strong TRPA1 agonist Relevant if sulforaphane or crucifer compounds are tracked separately.
Cinnamaldehyde / Cinnamon TRPA1 agonist Good tag under cinnamon or cinnamaldehyde.
Eugenol / Clove TRPA1 agonist/modulator Good tag under eugenol.
Gingerol / Ginger TRPA1 agonist Relevant if ginger or gingerol is in the database.
Cannabidiol / Cannabinoids TRPA1 agonist/modulator Mechanistically relevant, but pharmacology is broad.
Oleocanthal / Olive oil phenolics TRPA1 activation linked to pungency Lower cancer-specific relevance than allicin, allyl isothiocyanate, or cinnamaldehyde.


Scientific Papers found: Click to Expand⟱
6402- ANE,  FEO,    trans-Anethole of Fennel Oil is a Selective and Nonelectrophilic Agonist of the TRPA1 Ion Channel
- in-vitro, Nor, HEK293
*TRPA1↑, *Dose↝, *Bacteria↓, *Inflam↓,

Showing Research Papers: 1 to 1 of 1

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:


Total Targets: 0

Pathway results for Effect on Normal Cells:


NA, unassigned ⓘ

TRPA1↑, 1,  

Immune & Inflammatory Signaling ⓘ

Inflam↓, 1,  

Drug Metabolism & Resistance ⓘ

Dose↝, 1,  

Infection & Microbiome ⓘ

Bacteria↓, 1,  
Total Targets: 4

Scientific Paper Hit Count for: TRPA1, Transient Receptor Potential Ankyrin 1
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:1485  State#:%  Dir#:2
  wNotes=0  sortOrder:rid,rpid

 

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