TBX3 Cancer Research Results

TBX3, T-box transcription factor 3: Click to Expand ⟱
Source:
Type:

TBX3 is part of the T-box transcription factor family. It regulates developmental gene programs and is involved in cell-cycle control, senescence, proliferation, differentiation, and migration.

-TBX3 knockdown inhibited EMT, migration, invasion, and xenograft tumor growth in cervical cancer models
-Overexpression has been associated with progression in several cancers, including colorectal and breast cancer models.
Scientific Papers found: Click to Expand⟱
6466- 1,8-Cin,    Transcriptome Analysis Reveals the Anti-Tumor Mechanism of Eucalyptol Treatment on Neuroblastoma Cell Line SH-SY5Y
- in-vitro, neuroblastoma, SH-SY5Y
AntiTum↑, Previous studies have shown that eucalyptol has anti-tumor effects on leukemia and colon cancer.
TumCCA↑, GO function analysis showed that positive regulation of cell cycle was down-regulated in biological processes.
PDGFRB↓, fig 2
Myc↓, BAD3, TBX3 and APC were up-regulated genes, at the same time, oncogenes LEF1, PDGFRB, and MYC were down-regulated genes
LEF1↓,
BAD↑,
APC↑,
TBX3↑,


Showing Research Papers: 1 to 1 of 1

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:


NA, unassigned ⓘ

TBX3↑, 1,  

Cell Death ⓘ

BAD↑, 1,   Myc↓, 1,  

Cell Cycle & Senescence ⓘ

TumCCA↑, 1,  

Proliferation, Differentiation & Cell State ⓘ

PDGFRB↓, 1,  

Migration ⓘ

APC↑, 1,   LEF1↓, 1,  

Clinical Biomarkers ⓘ

Myc↓, 1,  

Functional Outcomes ⓘ

AntiTum↑, 1,  
Total Targets: 9

Pathway results for Effect on Normal Cells:


Total Targets: 0

Scientific Paper Hit Count for: TBX3, T-box transcription factor 3
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:1496  State#:%  Dir#:2
  wNotes=on  sortOrder:rid,rpid

 

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