TFAM Cancer Research Results

TFAM, Transcription factor A, mitochondrial: Click to Expand ⟱
Source:
Type:

TFAM, Transcription factor A, mitochondrial: Core mitochondrial transcription/mtDNA packaging factor; links directly to mitochondrial biogenesis, mtDNA copy number, oxidative stress, OXPHOS, aging, AD, and tumor metabolism.
-Therapeutic direction: Context-dependent; generally support/restore in AD, but tumor-stage and cancer-type specific in cancer.

Field Suggested Entry
Target TFAM
Full Name Transcription factor A, mitochondrial
Target Class Mitochondrial transcription factor; mtDNA packaging/nucleoid protein
Primary Biology mtDNA maintenance, mtDNA copy number regulation, mitochondrial transcription, mitochondrial biogenesis, nucleoid packaging, OXPHOS regulation
Cancer Relevance Medium and context-dependent: TFAM can support mitochondrial metabolism, OXPHOS, tumor stress tolerance, and progression in some cancers, but may also protect against mitochondrial instability and early tumorigenesis in other contexts
AD Relevance Medium-high: linked to impaired mitochondrial biogenesis, reduced mtDNA maintenance, oxidative stress, and neuronal energy dysfunction in AD and neurodegeneration
Therapeutic Direction Context-dependent. In AD/neurodegeneration, support or restore TFAM/PGC-1α/NRF1/NRF2 mitochondrial biogenesis signaling. In cancer, direction depends on tumor type, stage, and mitochondrial dependence.


Scientific Papers found: Click to Expand⟱
6510- BCP,  CBD,    Cannabidiol and Beta-Caryophyllene Combination Attenuates Diabetic Neuropathy by Inhibiting NLRP3 Inflammasome/NFκB through the AMPK/sirT3/Nrf2 Axis
- in-vivo, Nor, NA
*MMP↓, BC and CBD diminished HG-induced hyperglycemia in Schwann cells, in part by reducing mitochondrial membrane potential, reactive oxygen species, and mitochondrial superoxides.
*ROS↑,
*BloodF↑, while improving blood flow
*Pain↓, CBD and BC treatments also reduced pain hypersensitivity to hyperalgesia and allodynia, with increased antioxidant and anti-inflammatory action in diabetic rats.
*antiOx↑,
*Inflam↓,
*AMPK↑, in vivo effects were attributed to significant upregulation of AMPK, sirT3, Nrf2, PINK1, PARKIN, LC3B, Beclin1, and TFAM functions
*SIRT3↑,
*NRF2↑,
*PINK1↑,
*PARK2↑,
*LC3B↑,
*Beclin-1↑,
*TFAM↑,
*NLRP3↓, while downregulation of NLRP3 inflammasome, NFκB, COX2, and p62 activity was noted
*NF-kB↓,
*COX2↓,
*p62↓,
*NP/CIPN↓, CBD and BC combination ameliorates DN by modulating the mitochondrial quality control system.


Showing Research Papers: 1 to 1 of 1

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:


Total Targets: 0

Pathway results for Effect on Normal Cells:


NA, unassigned ⓘ

TFAM↑, 1,  

Redox & Oxidative Stress ⓘ

antiOx↑, 1,   NRF2↑, 1,   PARK2↑, 1,   ROS↑, 1,   SIRT3↑, 1,  

Mitochondria & Bioenergetics ⓘ

MMP↓, 1,   PINK1↑, 1,  

Core Metabolism/Glycolysis ⓘ

AMPK↑, 1,  

Autophagy & Lysosomes ⓘ

Beclin-1↑, 1,   LC3B↑, 1,   p62↓, 1,  

Immune & Inflammatory Signaling ⓘ

COX2↓, 1,   Inflam↓, 1,   NF-kB↓, 1,  

Protein Aggregation ⓘ

NLRP3↓, 1,  

Clinical Biomarkers ⓘ

BloodF↑, 1,  

Functional Outcomes ⓘ

NP/CIPN↓, 1,   Pain↓, 1,  
Total Targets: 19

Scientific Paper Hit Count for: TFAM, Transcription factor A, mitochondrial
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:1502  State#:%  Dir#:2
  wNotes=on  sortOrder:rid,rpid

 

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