NTF3/NT-3 Cancer Research Results

NTF3/NT-3, Neurotrophin-3: Click to Expand ⟱
Source:
Type:

NTF3
-Neurotrophin-3, originating from Müller glial cells in the retina, plays a key role in protecting photoreceptors from damage induced by light or hypoxia.

Field Suggested Entry
Target NTF3 / NT-3 / Neurotrophin-3
Full Name Neurotrophin 3
Target Class Secreted neurotrophic growth factor
Main Receptors TrkC / NTRK3; also TrkB / NTRK2 and p75NTR / NGFR in some contexts
Primary Biology Neuronal survival, differentiation, axonal growth, synaptic support, sensory neuron development, neurotrophic signaling
Cancer Relevance Medium and context-dependent: NT-3/TrkC signaling can support tumor survival, invasion, or metastasis in some cancers, but may promote differentiation or apoptosis in others depending on receptor context
AD Relevance Medium: neurotrophic support and neurodegeneration relevance, but less central than BDNF/TrkB
Therapeutic Direction In neurodegeneration, usually support/upregulate NT-3 neurotrophic signaling. In cancer, direction is context-dependent.


Scientific Papers found: Click to Expand⟱
6575- EU,    Eurycomanone from Eurycoma longifolia Jack upregulates neurotrophin-3 gene expression in retinal Müller cells in vitro
- in-vivo, Nor, NA
*Hypoxia↓, Neurotrophin-3, originating from Müller glial cells in the retina, plays a key role in protecting photoreceptors from damage induced by light or hypoxia.
*NTF3/NT-3↑, we demonstrated that the water extract of E. longifolia roots enhanced neurotrophin-3 gene expression in primary rat Müller cells.
*other↑, this study suggests that E. longifolia may be promising for improving eye health and must be further investigated.
*Half-Life↓, However, their clinical application presents challenges owing to their short plasma half-life (1.28 and 0.92 min for NT3 and BDNF, respectively) after intravenous administration


Showing Research Papers: 1 to 1 of 1

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:


Total Targets: 0

Pathway results for Effect on Normal Cells:


Transcription & Epigenetics(tgid=7) ⓘ

other↑, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

Hypoxia↓, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

NTF3/NT-3↑, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

Half-Life↓, 1,  
Total Targets: 4

Scientific Paper Hit Count for: NTF3/NT-3, Neurotrophin-3
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:1504  State#:%  Dir#:2
  wNotes=on  sortOrder:rid,rpid

 

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