Api Cancer Research Results

Api, Apigenin: Click to Expand ⟱
Source:
Type: Ingredient

Ingredient
Scientific Papers found: Click to Expand⟱
6666- DFE,    The impact of date palm fruits and their component polyphenols, on gut microbial ecology, bacterial metabolites and colon cancer cell proliferation
- in-vitro, Colon, Caco-2
*Fibre↑, The fruit of the date palm (Phoenix dactylifera L.) is a rich source of dietary fibre and polyphenols.
*Poly↑,
*other↝, investigated gut bacterial changes induced by the whole date fruit extract (digested date extract; DDE) and its polyphenol-rich extract (date polyphenol extract; DPE)
*QC↑, production of flavonoid aglycones (myricetin, luteolin, quercetin and apigenin) and the anthocyanidin petunidin in less than 1 h was also observed
*Api↑,
*Myr↑,
*LT↑,
TumCP↓, potential of DDE, DPE and metabolites to inhibit Caco-2 cell growth was investigated, indicating that both were capable of potentially acting as antiproliferative agents in vitro,
*GutMicro↑, a large number of human intervention studies have indicated that foods rich in fibres(18–25) and polyphenols(26–28) and/or rich in both compounds(29) have an impact on the gut microbiota
*Inflam↓, Ajwa variety of date, a common cultivar grown in Saudi Arabia, has been observed previously to exhibit anti-inflammatory and antioxidant potentials
*antiOx↑,

6663- DFE,    Nutraceuticals of Phoenix dactylifera L.: Physicochemistry, Nutritional Value and Therapeutic Potential
- Review, Nor, NA - Review, AD, NA
*antiOx↑, Date palm products are rich in carbohydrates, dietary fiber, essential minerals, and phenolic and flavonoid compounds, such as gallic acid, catechin, quercetin, and ferulic acid, which underpin their antioxidant and anti-inflammatory properties.
*Inflam↓,
*AntiBio↑, Experimental studies further suggest potential antimicrobial, antihyperlipidemic, antidiabetic, anticancer, anti-arthritic, neuroprotective, hepatoprotective, and gastroprotective effects.
*AntiDiabetic↑,
*AntiCan↑,
*AntiArt↑, biosynthesized AgNPs derived from date seed extracts has been reported to exhibit anti-arthritic activity in experimental models
*neuroP↑,
*hepatoP↑,
*GastroP↑,
*other↝, The mineral composition of date palm fruits (Table 6) reveals potassium as the most abundant mineral, followed by magnesium, calcium, and phosphorus.
*cardioP↑, This mineral profile supports the use of date palm fruit as a functional food for cardiovascular health, particularly in individuals with hypertension, due to its high potassium and low sodium content.
*cognitive↑, Multiple preclinical studies provided evidence that these compounds may enhance brain health and cognitive performance by mitigating oxidative stress and modulating inflammatory mediators, thus alleviating memory impairments and inflammation.
*ROS↓,
*memory↑, reported that date palm extracts were associated with improvements in memory performance, antioxidant enzyme activity, and preservation of neuronal morphology, particularly in the CA1 region of the hippocampus
*other↝, numerous literature have reported that both date fruit and seed extracts may alleviate oxidative stress, subsequently exerting anti-inflammatory, cardioprotective, and metabolic regulatory effects through modulation of related signaling pathways.
*SOD↑, Date fruit extract treatment was also found to restore antioxidant enzyme activities including superoxide dismutase (SOD) and catalase (CAT), and elevated glutathione (GSH) levels, further strengthening its proposed protective role against oxidative
*Catalase↑,
*GSH↑,
*GA↑, rich in phenolic acids and flavonoids, such as gallic acid, catechin, epicatechin, p-coumaric acid, ferulic acid, syringic acid, vanillic acid, quercetin, apigenin, caffeic acid, rutin, and lutein,
*Catechins↑,
*FA↑,
*QC↑,
Api↑,
*CA↑,
*Imm↑, Phoenix dactylifera L. extracts have also been reported to enhance immune function. The high polyphenol content in Phoenix dactylifera L. has been shown to stimulate immune responses
*Phen↑,
*IL1β↓, downregulation of pro-inflammatory mediators, including IL-1β, tumor growth factor (TGF)-β, COX-1, and COX-2, in middle-aged women following chronic consumption of date seed
*TGF-β↓,
*COX1↓,
*COX2↓,
TumCP↓, Phoenix dactylifera L. aqueous-ethanolic extract demonstrated antiproliferative and anti-inflammatory activities against human breast cancer cell lines (MDA-MB-231 and MCF-7)
Casp3↑, seed extracts demonstrated pro-apoptotic effects via caspase-3 activation in MDA‑MB‑231 cells
TumMeta↓, exhibited antiproliferative effects against U87 glioblastoma and MDA‑MB‑231 cells, along with significant inhibition of cell adhesion and migration, indicating potential anti-metastatic properties.
*GutMicro↑, It was suggested that daily consumption of dates may provide fermentable substrates for gut microbiota, thereby reducing toxic protein-derived metabolites.


Showing Research Papers: 1 to 2 of 2

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 2

Pathway results for Effect on Cancer / Diseased Cells:


Cell Death(tgid=5) ⓘ

Casp3↑, 1,  

Migration(tgid=13) ⓘ

TumCP↓, 2,   TumMeta↓, 1,  

Ingredients & Constituents(tgid=25) ⓘ

Api↑, 1,  
Total Targets: 4

Pathway results for Effect on Normal Cells:


NA, unassigned(tgid=0) ⓘ

AntiArt↑, 1,   AntiBio↑, 1,  

Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↑, 2,   Catalase↑, 1,   GSH↑, 1,   ROS↓, 1,   SOD↑, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

other↝, 3,  

Migration(tgid=13) ⓘ

TGF-β↓, 1,  

Barriers & Transport(tgid=15) ⓘ

GastroP↑, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

COX1↓, 1,   COX2↓, 1,   IL1β↓, 1,   Imm↑, 1,   Inflam↓, 2,  

Clinical Biomarkers(tgid=22) ⓘ

GutMicro↑, 2,  

Functional Outcomes(tgid=23) ⓘ

AntiCan↑, 1,   AntiDiabetic↑, 1,   cardioP↑, 1,   cognitive↑, 1,   hepatoP↑, 1,   memory↑, 1,   neuroP↑, 1,  

Ingredients & Constituents(tgid=25) ⓘ

Api↑, 1,   CA↑, 1,   Catechins↑, 1,   FA↑, 1,   Fibre↑, 1,   GA↑, 1,   LT↑, 1,   Myr↑, 1,   Phen↑, 1,   Poly↑, 1,   QC↑, 2,  
Total Targets: 34

Scientific Paper Hit Count for: Api, Apigenin
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:1515  State#:%  Dir#:2
  wNotes=on  sortOrder:rid,rpid

 

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