Phen Cancer Research Results
Phen, Phenolic Acids: Click to Expand ⟱
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Scientific Papers found: Click to Expand⟱
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*antiOx↑, Date palm products are rich in carbohydrates, dietary fiber, essential minerals, and phenolic and flavonoid compounds, such as gallic acid, catechin, quercetin, and ferulic acid, which underpin their antioxidant and anti-inflammatory properties.
*Inflam↓,
*AntiBio↑, Experimental studies further suggest potential antimicrobial, antihyperlipidemic, antidiabetic, anticancer, anti-arthritic, neuroprotective, hepatoprotective, and gastroprotective effects.
*AntiDiabetic↑,
*AntiCan↑,
*AntiArt↑, biosynthesized AgNPs derived from date seed extracts has been reported to exhibit anti-arthritic activity in experimental models
*neuroP↑,
*hepatoP↑,
*GastroP↑,
*other↝, The mineral composition of date palm fruits (Table 6) reveals potassium as the most abundant mineral, followed by magnesium, calcium, and phosphorus.
*cardioP↑, This mineral profile supports the use of date palm fruit as a functional food for cardiovascular health, particularly in individuals with hypertension, due to its high potassium and low sodium content.
*cognitive↑, Multiple preclinical studies provided evidence that these compounds may enhance brain health and cognitive performance by mitigating oxidative stress and modulating inflammatory mediators, thus alleviating memory impairments and inflammation.
*ROS↓,
*memory↑, reported that date palm extracts were associated with improvements in memory performance, antioxidant enzyme activity, and preservation of neuronal morphology, particularly in the CA1 region of the hippocampus
*other↝, numerous literature have reported that both date fruit and seed extracts may alleviate oxidative stress, subsequently exerting anti-inflammatory, cardioprotective, and metabolic regulatory effects through modulation of related signaling pathways.
*SOD↑, Date fruit extract treatment was also found to restore antioxidant enzyme activities including superoxide dismutase (SOD) and catalase (CAT), and elevated glutathione (GSH) levels, further strengthening its proposed protective role against oxidative
*Catalase↑,
*GSH↑,
*GA↑, rich in phenolic acids and flavonoids, such as gallic acid, catechin, epicatechin, p-coumaric acid, ferulic acid, syringic acid, vanillic acid, quercetin, apigenin, caffeic acid, rutin, and lutein,
*Catechins↑,
*FA↑,
*QC↑,
Api↑,
*CA↑,
*Imm↑, Phoenix dactylifera L. extracts have also been reported to enhance immune function. The high polyphenol content in Phoenix dactylifera L. has been shown to stimulate immune responses
*Phen↑,
*IL1β↓, downregulation of pro-inflammatory mediators, including IL-1β, tumor growth factor (TGF)-β, COX-1, and COX-2, in middle-aged women following chronic consumption of date seed
*TGF-β↓,
*COX1↓,
*COX2/PTGS2↓,
TumCP↓, Phoenix dactylifera L. aqueous-ethanolic extract demonstrated antiproliferative and anti-inflammatory activities against human breast cancer cell lines (MDA-MB-231 and MCF-7)
Casp3↑, seed extracts demonstrated pro-apoptotic effects via caspase-3 activation in MDA‑MB‑231 cells
TumMeta↓, exhibited antiproliferative effects against U87 glioblastoma and MDA‑MB‑231 cells, along with significant inhibition of cell adhesion and migration, indicating potential anti-metastatic properties.
*GutMicro↑, It was suggested that daily consumption of dates may provide fermentable substrates for gut microbiota, thereby reducing toxic protein-derived metabolites.
*AntiBio↑, Evidence shows that antimicrobial performance increases with oxidation level,
*eff↝, However, the application of gaseous ozone in food systems is constrained by its instability, short half-life, limited penetration into food matrices, and potential for inducing undesirable oxidative changes in lipids and other sensitive food componen
*Half-Life↝, Ozone typically has a 20–30 min of half-life in aqueous solutions at room temperature (not OIL)
*eff↑, At lower temperatures, ozone exhibits higher solubility and longer lifetime in the oil phase, f
*Phen↑, Obadi et al. [70] observed a significant increase in total phenolic content (from 6.09 to up to 19.77 mg GAE/g) and antioxidant activity after treatment, suggesting that ozone may disrupt cellular structures and release bound phenolic compounds.
*antiOx↑,
eff↝, Their study revealed that during short ozone contact times, higher amounts of TPC, 15.47 and 12.91 mg CE/g of extract appeared, whereas high ozonated exhibited the lowest amount of phenolics,
eff↝, double-edged process: while it can enhance antioxidant content and release valuable minor compounds under controlled conditions, excessive treatment promotes lipid oxidation, degradation of key nutrients such as α-tocopherol,
Showing Research Papers: 1 to 2 of 2
* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 2
Pathway results for Effect on Cancer / Diseased Cells:
Cell Death(tgid=5) ⓘ
Casp3↑, 1,
Migration(tgid=13) ⓘ
TumCP↓, 1, TumMeta↓, 1,
Drug Metabolism & Resistance(tgid=21) ⓘ
eff↝, 2,
Ingredients & Constituents(tgid=25) ⓘ
Api↑, 1,
Total Targets: 5
Pathway results for Effect on Normal Cells:
NA, unassigned(tgid=0) ⓘ
AntiArt↑, 1, AntiBio↑, 2,
Redox & Oxidative Stress(tgid=1) ⓘ
antiOx↑, 2, Catalase↑, 1, GSH↑, 1, ROS↓, 1, SOD↑, 1,
Transcription & Epigenetics(tgid=7) ⓘ
other↝, 2,
Migration(tgid=13) ⓘ
TGF-β↓, 1,
Barriers & Transport(tgid=15) ⓘ
GastroP↑, 1,
Immune & Inflammatory Signaling(tgid=16) ⓘ
COX1↓, 1, COX2/PTGS2↓, 1, IL1β↓, 1, Imm↑, 1, Inflam↓, 1,
Drug Metabolism & Resistance(tgid=21) ⓘ
eff↑, 1, eff↝, 1, Half-Life↝, 1,
Clinical Biomarkers(tgid=22) ⓘ
GutMicro↑, 1,
Functional Outcomes(tgid=23) ⓘ
AntiCan↑, 1, AntiDiabetic↑, 1, cardioP↑, 1, cognitive↑, 1, hepatoP↑, 1, memory↑, 1, neuroP↑, 1,
Ingredients & Constituents(tgid=25) ⓘ
CA↑, 1, Catechins↑, 1, FA↑, 1, GA↑, 1, Phen↑, 2, QC↑, 1,
Total Targets: 32
Scientific Paper Hit Count for: Phen, Phenolic Acids
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include :
-low or high Dose
-format for product, such as nano of lipid formations
-different cell line effects
-synergies with other products
-if effect was for normal or cancerous cells
Filter Conditions: Pro/AntiFlg:% IllCat:% CanType:% Cells:% prod#:% Target#:1516 State#:% Dir#:2
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