GlyFlow Cancer Research Results

GlyFlow, Glymphatic flow: Click to Expand ⟱
Source:
Type:

The glymphatic system supports cerebrospinal fluid–interstitial fluid exchange and clearance of metabolites and proteins, including amyloid-β and tau. Impaired glymphatic function is increasingly studied as an AD-associated biomarker and potential therapeutic pathway.
Scientific Papers found: Click to Expand⟱
6929- FLS,  AudGS,    Multisensory gamma stimulation promotes glymphatic clearance of amyloid
- in-vivo, AD, NA
*pol-AQPs↑, Influx of cerebrospinal fluid was associated with increased aquaporin-4 polarization along astrocytic endfeet and dilated meningeal lymphatic vessels.
*Aβ↓, Our findings establish novel mechanisms that recruit the glymphatic system to remove brain amyloid.
*GlyFlow↑,

6930- FLS,    40 Hz light flickering facilitates the glymphatic flow via adenosine signaling in mice
*GlyFlow↑, 40 Hz light flickering enhanced glymphatic influx and efflux independently of anesthesia and sleep,
*e-ADO↑, First, brief 40 Hz light flickering produces a robust and sustained increase in the extracellular adenosine levels in the primary visual cortex and other brain regions
*Sleep↑, Second, 40 Hz light flickering promotes sleep18, when the glymphatic system is mostly active
*Dose↝, 30-min exposure to light flickering (white light, illuminance of 3000 lux, irradiance of 1.10 mW/cm2 at 20 cm distance, 50% duty cycle) at 40 Hz
*AQPs↑, Accordingly, we found that 40 Hz light flickering increased the gene expression of AQP4-M23
BloodF↑, 40 Hz light flickering increases vasomotion and cerebral blood flow (CBF)

6943- FLS,    Promoting glymphatic flow: A non-invasive strategy using 40 Hz light flickering
- Review, AD, NA
*GlyFlow↑, Previous studies have uncovered that 40 Hz flickering augmented glymphatic flow and facilitated sleep
*Sleep↑,
*AQPs↑, by promoting the polarization of astrocytic aquaporin-4 (AQP4) and vasomotion through upregulated adenosine-A2A receptor (A2AR) signaling, independent of sleep.
*neuroP↑, presenting a potential strategy for neurodegenerative disease treatment.


Showing Research Papers: 1 to 3 of 3

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 3

Pathway results for Effect on Cancer / Diseased Cells:


Clinical Biomarkers(tgid=22) ⓘ

BloodF↑, 1,  
Total Targets: 1

Pathway results for Effect on Normal Cells:


NA, unassigned(tgid=0) ⓘ

e-ADO↑, 1,   GlyFlow↑, 3,  

Barriers & Transport(tgid=15) ⓘ

AQPs↑, 2,   pol-AQPs↑, 1,  

Protein Aggregation(tgid=19) ⓘ

Aβ↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

Dose↝, 1,  

Functional Outcomes(tgid=23) ⓘ

neuroP↑, 1,   Sleep↑, 2,  
Total Targets: 8

Scientific Paper Hit Count for: GlyFlow, Glymphatic flow
3 Flickering Light Stimulation
1 Auditory Gamma Stimulation / 40 Hz Auditory Stimulation
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:1538  State#:%  Dir#:2
  wNotes=on  sortOrder:rid,rpid

 

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