miR-490 Cancer Research Results

miR-490, miR-490: Click to Expand ⟱
Source:
Type:

MicroRNA-490 (miR-490) produces two mature strands, miR-490-3p and miR-490-5p, which can regulate different messenger-RNA targets and should be recorded separately whenever the study identifies the strand. In many cancers, miR-490 ↓ is the more commonly reported pattern, and both miR-490-3p and miR-490-5p frequently function as tumour-suppressive microRNAs. Restoration or miR-490 ↑ has been associated with reduced proliferation, migration, invasion, epithelial-mesenchymal transition, tumour growth, and treatment resistance, together with increased apoptosis in susceptible cancer models. Reported targets include CCND1, ERGIC3, VDAC1, c-FOS, and other tumour- and strand-specific genes. However, oncogenic activity has been reported for miR-490-3p in selected settings, including some hepatocellular carcinoma models. The typical cancer-associated direction is miR-490 ↓, while treatment-induced miR-490 ↑ is usually interpreted as beneficial. Cancer review; miR-490-3p colorectal cancer study.



Scientific Papers found: Click to Expand⟱
6975- Form,    Formononetin inhibits colorectal cancer via the miR-490-3p/ABCC2 axis and synergizes with 5-fluorouracil: mechanistic insights and therapeutic implications
- vitro+vivo, CRC, NA
TumCP↓, MRP↓, miR-490↑, eff⇅, ChemoSen↑, ABCC2↓,

Showing Research Papers: 1 to 1 of 1

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:


NA, unassigned(tgid=0) ⓘ

ABCC2↓, 1,   miR-490↑, 1,  

Migration(tgid=13) ⓘ

TumCP↓, 1,  

Barriers & Transport(tgid=15) ⓘ

MRP↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

ChemoSen↑, 1,   eff⇅, 1,  
Total Targets: 6

Pathway results for Effect on Normal Cells:


Total Targets: 0

Scientific Paper Hit Count for: miR-490, miR-490
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:1544  State#:%  Dir#:2
  wNotes=0  sortOrder:rid,rpid

 

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