miR-545 Cancer Research Results

miR-545, miR-545: Click to Expand ⟱
Source:
Type:

MicroRNA-545 (miR-545; principally miR-545-3p, with miR-545-5p as the alternate mature strand) is a small non-coding RNA that regulates gene expression through transcript degradation or translational repression. In many cancers, miR-545-3p ↓ has been reported and restoration of miR-545 can inhibit proliferation, migration, invasion, epithelial-mesenchymal transition, tumour growth, and treatment resistance. Reported tumour-suppressive targets and pathways include RIG-I/DDX58, PLK1, ZEB2/WNT/β-catenin, LAMC2, HK2, and MT1M. However, miR-545 can act oncogenically in selected settings: miR-545 ↑ has been associated with increased proliferation and poorer prognosis in some hepatocellular and colorectal cancer studies. Cancer review; Tumour-suppressive example; Oncogenic example.
-miR-545-3p ↓ is commonly adverse and restoration is often anticancer, but miR-545 ↑ can be oncogenic in selected cancers.



Scientific Papers found: Click to Expand⟱
6985- Form,    Formononetin relieves the facilitating effect of lncRNA AFAP1-AS1-miR-195/miR-545 axis on progression and chemo-resistance of triple-negative breast cancer
- in-vitro, BC, MDA-MB-231 - in-vitro, BC, BT549
CDK4↓, Raf↓, miR-195↑, miR-545↑, ChemoSen↑, AFAP1-AS1↓,

Showing Research Papers: 1 to 1 of 1

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:


NA, unassigned(tgid=0) ⓘ

AFAP1-AS1↓, 1,   miR-195↑, 1,   miR-545↑, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

Raf↓, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

CDK4↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

ChemoSen↑, 1,  
Total Targets: 6

Pathway results for Effect on Normal Cells:


Total Targets: 0

Scientific Paper Hit Count for: miR-545, miR-545
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:1555  State#:%  Dir#:2
  wNotes=0  sortOrder:rid,rpid

 

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