DCR Cancer Research Results

DCR, Disease control rate: Click to Expand ⟱
Source:
Type: clinical outcome

DCR is generally calculated as:
DCR = complete response (CR) + partial response (PR) + stable disease (SD)
Scientific Papers found: Click to Expand⟱
7000- Fuc,    Efficacy of Low-Molecular-Weight Fucoidan as a Supplemental Therapy in Metastatic Colorectal Cancer Patients: A Double-Blind Randomized Controlled Trial
- Trial, CRC, NA
DCR↑, results indicate that LMF combined with chemotarget agents significantly improved the DCR.
OS∅, OS, PFS, ORR, AEs, and QOL did not significantly differ between the two groups
PFS∅,
ORR∅,
AEs∅,
QoL∅,

7004- Fuc,    Effectiveness of Fucoidan on Supplemental Therapy in Cancer Patients: A Systematic Review
- Review, Var, NA
OS↑, Two studies revealed a significantly longer survival time and chemotherapy treatment periods with fucoidan use.
DCR↑, Positive but insignificant effects of disease control rate, inflammatory markers, nutrition status, fatigue, and financial difficulty were shown in those using fucoidan.
Inflam↓,
fatigue↓,

7061- GamB,    An open-labeled, randomized, multicentered, phase IIa study for advanced cancer treatment by gambogic acid injection (THS)
- Trial, Var, NA
ORR↑, Observed an objective remission rate (ORR) of 14.29% and an overall disease control rate (DCR) of 76.2% in arm A compare to observed an ORR of 0.00% and a DCR of 61.5% in arm B.
DCR↑,
*toxicity↓, The preliminary results of the exploratory study indicated favorable safety profiles at 45mg/m2 in this phase IIa clinical study.


Showing Research Papers: 1 to 3 of 3

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 3

Pathway results for Effect on Cancer / Diseased Cells:


NA, unassigned(tgid=0) ⓘ

AEs∅, 1,   DCR↑, 3,   ORR↑, 1,   ORR∅, 1,   PFS∅, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

Inflam↓, 1,  

Functional Outcomes(tgid=23) ⓘ

fatigue↓, 1,   OS↑, 1,   OS∅, 1,   QoL∅, 1,  
Total Targets: 10

Pathway results for Effect on Normal Cells:


Functional Outcomes(tgid=23) ⓘ

toxicity↓, 1,  
Total Targets: 1

Scientific Paper Hit Count for: DCR, Disease control rate
2 Fucoidan
1 Gambogic Acid
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:1558  State#:%  Dir#:2
  wNotes=on  sortOrder:rid,rpid

 

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