ORR Cancer Research Results

ORR, overall response rate: Click to Expand ⟱
Source:
Type:

overall response rate (ORR)
Scientific Papers found: Click to Expand⟱
7061- GamB,    An open-labeled, randomized, multicentered, phase IIa study for advanced cancer treatment by gambogic acid injection (THS)
- Trial, Var, NA
ORR↑, Observed an objective remission rate (ORR) of 14.29% and an overall disease control rate (DCR) of 76.2% in arm A compare to observed an ORR of 0.00% and a DCR of 61.5% in arm B.
DCR↑,
*toxicity↓, The preliminary results of the exploratory study indicated favorable safety profiles at 45mg/m2 in this phase IIa clinical study.

7289- GGB,    The Efficacy of Ginsenoside Rg3 Combined with First-line Chemotherapy in the Treatment of Advanced Non-Small Cell Lung Cancer in China: A Systematic Review and Meta-Analysis of Randomized Clinical Trials
- Review, Var, NA
ORR↑, The results showed that compared with first-line chemotherapy alone, the combination of ginsenoside Rg3 and first-line chemotherapy could better improve the objective response rate (ORR)
ChemoSen↑,
OS↑, , one-year survival rate (RR [95% CI], 1.49 [1.08, 2.06], p = 0.01), two-year survival rate (RR [95% CI], 6.22 [1.68, 22.95], p = 0.006), weight change (RR [95% CI], 1.31 [1.04, 1.66], p = 0.02), and higher reduce the VEGF levels
Weight↓, Compared with the control group, the experimental group had a higher rate of weight improvement. (RR [95% CI], 1.31 [1.04, 1.66], p = 0.02)
VEGF↑,

7320- Gos,    AT-101 Enhances the Antitumor Activity of Lenalidomide in Patients with Multiple Myeloma
- Trial, Melanoma, NA
Bcl-2↓, AT-101 is an oral drug, which disrupts Bcl-2 and Mcl-1 function, impedes mitochondrial bioenergetic processes and induces apoptosis in MM cells.
Mcl-1↓,
Apoptosis↑,
eff↑, When combined with lenalidomide and dexamethasone (Rd), AT-101 significantly reduced tumor burden in an in vivo xenograft model of MM.
toxicity↝, The ARd combination was well tolerated with most common grade 3/4 adverse events being cytopenia’s.
ORR↑, The overall response rate was 40% and clinical benefit rate was 90%. The median progression free survival was 14.9 months (95% CI 7.1-NE).

7618- HPT,    ESHO 2-85. Hyperthermia as an adjuvant to radiation therapy in the treatment of advanced neck nodes: A randomized multicenter study by the European Society for Hyperthermic Oncology
ORR↑, complete response rate was 53% in the RT versus 80% in the RT+HT group, and 3-year persistent local control rate was 32% for RT alone versus 53% for RT+HT; HR: 0.48 [0.23–0.98].
NA↑, The ESHO 2–85 study demonstrated that addition of a weekly HT treatment to RT of advanced neck nodes significantly enhanced the persistent tumor control.
NA↑, HT was associated with moderate to severe pain and discomfort in 38% of the treatments.
BioAv↝, The clinical application of heat was (and still is) hampered by the difficulties to provide a homogeneous heating to a given target.
Dose↝, Each heat session should aim for a minimal tumor temperature 60 min at 43.0°C or equivalen
Dose↝, HT was applied with electromagnetic heating.

7597- HPT,    Comparison of radiotherapy alone with radiotherapy plus hyperthermia in locally advanced pelvic tumours: a prospective, randomised, multicentre trial. Dutch Deep Hyperthermia Group
- Trial, Var, NA
ORR↑, Complete-response rates were 39% after radiotherapy and 55% after radiotherapy plus hyperthermia
OS↑, 3-year overall survival was 27% in the radiotherapy group and 51% in the radiotherapy plus hyperthermia group


Showing Research Papers: 1 to 5 of 5

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 5

Pathway results for Effect on Cancer / Diseased Cells:


NA, unassigned(tgid=0) ⓘ

DCR↑, 1,   NA↑, 2,   ORR↑, 5,  

Cell Death(tgid=5) ⓘ

Apoptosis↑, 1,   Bcl-2↓, 1,   Mcl-1↓, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

VEGF↑, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↝, 1,   ChemoSen↑, 1,   Dose↝, 2,   eff↑, 1,  

Functional Outcomes(tgid=23) ⓘ

OS↑, 2,   toxicity↝, 1,   Weight↓, 1,  
Total Targets: 14

Pathway results for Effect on Normal Cells:


Functional Outcomes(tgid=23) ⓘ

toxicity↓, 1,  
Total Targets: 1

Scientific Paper Hit Count for: ORR, overall response rate
2 Hyperthermia
1 Gambogic Acid
1 Ginkgolide B
1 Gossypol/AT-101
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:1560  State#:%  Dir#:2
  wNotes=on  sortOrder:rid,rpid

 

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