VMP-1 Cancer Research Results

VMP-1, Vacuole membrane protein 1: Click to Expand ⟱
Source:
Type:

Vacuole membrane protein 1 (VMP1) is a transmembrane protein that plays an important role in autophagosome formation, autophagic flux, membrane organization, and endoplasmic-reticulum contact sites. In cancer, VMP1 expression and activity are context-dependent. In many established tumours, VMP1 ↑ can increase protective autophagy, allowing cancer cells to survive nutrient deprivation, hypoxia, oxidative stress, and anticancer treatment. VMP1-mediated autophagy has been associated with tumour progression and chemotherapy resistance, particularly in pancreatic cancer, where KRAS signalling and gemcitabine treatment can induce VMP1. Conversely, deficient VMP1 or impaired autophagic flux may contribute to cellular damage and tumour initiation in selected settings. Gene reference; Cancer review.



Scientific Papers found: Click to Expand⟱
7019- Fuc,    Fucoidan protects hepatocytes from apoptosis and inhibits invasion of hepatocellular carcinoma by up-regulating p42/44 MAPK-dependent NDRG-1/CAP43
- vitro+vivo, HCC, HUH7
TumCI↓, p42↑, p44↑, MAPK↑, TumMeta↓, hepatoP↑, *antiOx↑, *TumCP↓, Vim↓, E-cadherin↓, Fibronectin↓, NDRG1↑, VMP-1↑, TumMeta↓,

Showing Research Papers: 1 to 1 of 1

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:


NA, unassigned(tgid=0) ⓘ

VMP-1↑, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

p42↑, 1,  

Cell Death(tgid=5) ⓘ

MAPK↑, 1,  

Migration(tgid=13) ⓘ

E-cadherin↓, 1,   Fibronectin↓, 1,   p44↑, 1,   TumCI↓, 1,   TumMeta↓, 2,   Vim↓, 1,  

Functional Outcomes(tgid=23) ⓘ

hepatoP↑, 1,   NDRG1↑, 1,  
Total Targets: 11

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↑, 1,  

Migration(tgid=13) ⓘ

TumCP↓, 1,  
Total Targets: 2

Scientific Paper Hit Count for: VMP-1, Vacuole membrane protein 1
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:1565  State#:%  Dir#:2
  wNotes=0  sortOrder:rid,rpid

 

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