VMP-1 Cancer Research Results

VMP-1, Vacuole membrane protein 1: Click to Expand ⟱
Source:
Type:

Vacuole membrane protein 1 (VMP1) is a transmembrane protein that plays an important role in autophagosome formation, autophagic flux, membrane organization, and endoplasmic-reticulum contact sites. In cancer, VMP1 expression and activity are context-dependent. In many established tumours, VMP1 ↑ can increase protective autophagy, allowing cancer cells to survive nutrient deprivation, hypoxia, oxidative stress, and anticancer treatment. VMP1-mediated autophagy has been associated with tumour progression and chemotherapy resistance, particularly in pancreatic cancer, where KRAS signalling and gemcitabine treatment can induce VMP1. Conversely, deficient VMP1 or impaired autophagic flux may contribute to cellular damage and tumour initiation in selected settings. Gene reference; Cancer review.



Scientific Papers found: Click to Expand⟱
7019- Fuc,    Fucoidan protects hepatocytes from apoptosis and inhibits invasion of hepatocellular carcinoma by up-regulating p42/44 MAPK-dependent NDRG-1/CAP43
- vitro+vivo, HCC, HUH7
TumCI↓, Fucoidan was found to suppress the invasion of HCC cells through up-regulation of p42/44 MAPK-dependent NDRG-1/CAP43 and partly, under normoxic conditions, through up-regulation of p42/44 MAPK-dependent VMP-1 expression.
p42↑,
p44↑,
MAPK↑,
TumMeta↓, It also significantly decreased liver metastasis in vivo
hepatoP↑, As regards its hepatoprotective effect, fucoidan decreased BA-induced hepatocyte apoptosis as shown by the attenuation of caspase-8, and -7 cleavages and suppression of the mobilization of caspase-8 and Fas associated death domain (FADD) into the dea
*antiOx↑, Fucoidan has also been reported to exert a protective effect on hepatocytes showing anti-oxidative effects against acute liver injury and liver fibrosis
*TumCP↓, Cell proliferation following fucoidan treatment decreased in a dose-dependent manner under both normoxic and hypoxic conditions
Vim↓, fucoidan treatment was found to decrease the expressions of vimentin, E-cadherin, and fibronectin in Huh-7 cells as compared to controls
E-cadherin↓,
Fibronectin↓,
NDRG1↑, Fucoidan enhances the expression of NDRG-1/CAP43 by the p42/44 MAPK pathway
VMP-1↑, Enhanced expression of VMP-1 by fucoidan under normoxic conditions
TumMeta↓, Fucoidan inhibited liver metastasis in an intrahepatic portal vein metastasis model in vivo


Showing Research Papers: 1 to 1 of 1

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:


NA, unassigned(tgid=0) ⓘ

VMP-1↑, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

p42↑, 1,  

Cell Death(tgid=5) ⓘ

MAPK↑, 1,  

Migration(tgid=13) ⓘ

E-cadherin↓, 1,   Fibronectin↓, 1,   p44↑, 1,   TumCI↓, 1,   TumMeta↓, 2,   Vim↓, 1,  

Functional Outcomes(tgid=23) ⓘ

hepatoP↑, 1,   NDRG1↑, 1,  
Total Targets: 11

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↑, 1,  

Migration(tgid=13) ⓘ

TumCP↓, 1,  
Total Targets: 2

Scientific Paper Hit Count for: VMP-1, Vacuole membrane protein 1
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:1565  State#:%  Dir#:2
  wNotes=on  sortOrder:rid,rpid

 

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