DIDO1/DIO-1 Cancer Research Results

DIDO1/DIO-1, death inducer-obliterator: Click to Expand ⟱
Source:
Type:

DIDO1 (death-inducer obliterator 1; DIO-1) is a nuclear regulatory protein encoded by the DIDO1 gene and produced in several alternatively spliced isoforms. DIDO1 was initially identified as an apoptosis-associated factor: apoptotic stimuli increase its expression, promote its translocation from the cytoplasm to the nucleus and can increase caspase-3 and caspase-9 expression or activation. Overexpression of DIO-1 induced apoptosis in early cell models. However, DIDO1 also participates in transcriptional regulation, RNA processing, stem-cell differentiation, cell-cycle control and maintenance of genomic stability. Its role in cancer is therefore context-dependent. In some malignancies, elevated DIDO1 supports proliferation, migration, invasion or apoptosis resistance, and DIDO1 silencing suppresses tumour-cell growth. In other contexts, loss or dysfunction of DIDO1 may contribute to genomic instability and myeloid neoplasia. DIO-1 is an older protein designation; the preferred official target name is DIDO1.



Scientific Papers found: Click to Expand⟱
7060- GamB,    New targets for the antitumor activity of gambogic acid in hematologic malignancies
- Review, Melanoma, RPMI-8226
AntiCan↑, TumCP↓, Apoptosis↑, SRC3↓, DIDO1/DIO-1↑, KCNH2/hERG↓, ROS↑, Bcl-2↓, P53↑, cMyc↓, VEGF↓, Casp3↑, cl‑PARP1↑, eff↓,

Showing Research Papers: 1 to 1 of 1

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:


NA, unassigned(tgid=0) ⓘ

DIDO1/DIO-1↑, 1,   KCNH2/hERG↓, 1,   SRC3↓, 1,  

Redox & Oxidative Stress(tgid=1) ⓘ

ROS↑, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

cMyc↓, 1,  

Cell Death(tgid=5) ⓘ

Apoptosis↑, 1,   Bcl-2↓, 1,   Casp3↑, 1,  

DNA Damage & Repair(tgid=10) ⓘ

P53↑, 1,   cl‑PARP1↑, 1,  

Migration(tgid=13) ⓘ

TumCP↓, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

VEGF↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

eff↓, 1,  

Functional Outcomes(tgid=23) ⓘ

AntiCan↑, 1,  
Total Targets: 14

Pathway results for Effect on Normal Cells:


Total Targets: 0

Scientific Paper Hit Count for: DIDO1/DIO-1, death inducer-obliterator
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:1572  State#:%  Dir#:2
  wNotes=0  sortOrder:rid,rpid

 

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