JAG1 Cancer Research Results

JAG1, Jagged canonical Notch ligand 1: Click to Expand ⟱
Source:
Type:

JAG1 (Jagged canonical Notch ligand 1; Jagged1) is a membrane-bound ligand that activates NOTCH-family receptors on adjacent cells. JAG1–Notch signalling regulates cell fate, differentiation, stem-cell maintenance, angiogenesis and communication between tumour cells and the tumour microenvironment. JAG1 is frequently overexpressed in established cancers and can promote cancer-stem-cell properties, proliferation, epithelial–mesenchymal transition, migration, invasion, angiogenesis, metastasis and resistance to anticancer treatment. JAG1 inhibition or downregulation has reduced tumour-cell growth and invasiveness in several preclinical models. The typical cancer-associated direction is up, while the desired anticancer modulation is generally down or blockade of JAG1–Notch signalling.



Scientific Papers found: Click to Expand⟱
7105- GEN,    Effects of genistein supplementation on genome‑wide DNA methylation and gene expression in patients with localized prostate cancer
- Trial, Pca, NA
Risk↓, Myc↓, PTEN↑, Dose↝, NOTCH3↑, JAG1↑, ADCY4↑, NEU1↑,

Showing Research Papers: 1 to 1 of 1

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:


NA, unassigned(tgid=0) ⓘ

ADCY4↑, 1,   JAG1↑, 1,   NEU1↑, 1,  

Cell Death(tgid=5) ⓘ

Myc↓, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

NOTCH3↑, 1,   PTEN↑, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

Dose↝, 1,  

Clinical Biomarkers(tgid=22) ⓘ

Myc↓, 1,  

Functional Outcomes(tgid=23) ⓘ

Risk↓, 1,  
Total Targets: 9

Pathway results for Effect on Normal Cells:


Total Targets: 0

Scientific Paper Hit Count for: JAG1, Jagged canonical Notch ligand 1
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:1579  State#:%  Dir#:2
  wNotes=0  sortOrder:rid,rpid

 

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