ADCY4 Cancer Research Results

ADCY4, adenylate cyclase 4; adenylyl cyclase 4; AC4: Click to Expand ⟱
Source:
Type:

ADCY4 (adenylate cyclase 4; adenylyl cyclase 4; AC4) is a membrane-associated enzyme that converts ATP into cyclic AMP (cAMP) in response to G-protein-coupled-receptor signalling. Through cAMP, ADCY4 can influence PKA, CREB, EPAC, calcium regulation, transcription, metabolism, proliferation and differentiation. Altered ADCY4 expression or DNA methylation has been identified in some cancers, including breast cancer, suggesting potential use as a biomarker and signalling regulator. However, current evidence does not establish ADCY4 as a broadly oncogenic or tumour-suppressive target across cancers.



Scientific Papers found: Click to Expand⟱
7105- GEN,    Effects of genistein supplementation on genome‑wide DNA methylation and gene expression in patients with localized prostate cancer
- Trial, Pca, NA
Risk↓, Myc↓, PTEN↑, Dose↝, NOTCH3↑, JAG1↑, ADCY4↑, NEU1↑,

Showing Research Papers: 1 to 1 of 1

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:


NA, unassigned(tgid=0) ⓘ

ADCY4↑, 1,   JAG1↑, 1,   NEU1↑, 1,  

Cell Death(tgid=5) ⓘ

Myc↓, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

NOTCH3↑, 1,   PTEN↑, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

Dose↝, 1,  

Clinical Biomarkers(tgid=22) ⓘ

Myc↓, 1,  

Functional Outcomes(tgid=23) ⓘ

Risk↓, 1,  
Total Targets: 9

Pathway results for Effect on Normal Cells:


Total Targets: 0

Scientific Paper Hit Count for: ADCY4, adenylate cyclase 4; adenylyl cyclase 4; AC4
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:1580  State#:%  Dir#:2
  wNotes=0  sortOrder:rid,rpid

 

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