NEU1 Cancer Research Results

NEU1, neuraminidase 1: Click to Expand ⟱
Source:
Type:

NEU1 (neuraminidase 1; lysosomal sialidase 1) is a glycohydrolase that removes terminal sialic-acid residues from glycoproteins and glycolipids. NEU1 functions mainly in lysosomes but can also participate in cell-surface receptor regulation, adhesion, autophagy, inflammation and growth factor signalling. Altered NEU1 activity can modify the sialylation, stability and signalling of receptors and adhesion molecules, thereby affecting proliferation, survival, migration and invasion. Its role in cancer is context-dependent: increased NEU1 has promoted tumour growth or migration in some models, whereas reduced NEU1 has increased aggressiveness in others, including reported cervical-cancer models.



Scientific Papers found: Click to Expand⟱
7105- GEN,    Effects of genistein supplementation on genome‑wide DNA methylation and gene expression in patients with localized prostate cancer
- Trial, Pca, NA
Risk↓, Myc↓, PTEN↑, Dose↝, NOTCH3↑, JAG1↑, ADCY4↑, NEU1↑,

Showing Research Papers: 1 to 1 of 1

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:


NA, unassigned(tgid=0) ⓘ

ADCY4↑, 1,   JAG1↑, 1,   NEU1↑, 1,  

Cell Death(tgid=5) ⓘ

Myc↓, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

NOTCH3↑, 1,   PTEN↑, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

Dose↝, 1,  

Clinical Biomarkers(tgid=22) ⓘ

Myc↓, 1,  

Functional Outcomes(tgid=23) ⓘ

Risk↓, 1,  
Total Targets: 9

Pathway results for Effect on Normal Cells:


Total Targets: 0

Scientific Paper Hit Count for: NEU1, neuraminidase 1
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:1581  State#:%  Dir#:2
  wNotes=0  sortOrder:rid,rpid

 

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