PKLR Cancer Research Results

PKLR, pyruvate kinase L/R: Click to Expand ⟱
Source:
Type:

PKLR (pyruvate kinase L/R) encodes the liver-type (PKL) and red-blood-cell-type (PKR) pyruvate kinase isoforms, which catalyze the final ATP-generating step of glycolysis by converting phosphoenolpyruvate to pyruvate. PKLR expression is normally tissue-restricted, but aberrant expression can contribute to tumour metabolic adaptation. In colorectal cancer, PKLR is increased in primary tumours associated with metastatic disease and in liver metastases, where it promotes survival under hypoxic and high-cell-density conditions partly by increasing glutathione-dependent antioxidant capacity. PKLR has also been implicated in enhanced glycolytic metabolism in hepatocellular carcinoma. In these tumour contexts, the typical cancer-associated direction is up, while the desired anticancer modulation is generally down. However, PKLR is not as universally cancer-associated as PKM2, so its direction should remain tumour-specific. PKLR is separate from PKM, which encodes the distinct PKM1 and PKM2 isoforms.



Scientific Papers found: Click to Expand⟱
7167- CHA,    Chaetocin-induced ROS-mediated apoptosis involves ATM-YAP1 axis and JNK-dependent inhibition of glucose metabolism
- vitro+vivo, GBM, A172 - in-vitro, GBM, T98G - in-vitro, GBM, U87MG
HMTs↓, ROS↑, YAP/TEAD↑, ATM↑, JNK↑, Apoptosis↑, GlucoseCon↓, lactateProd↓, ATP↓, TumCP↓, TrxR↓, Trx1↓, H3K9↓, p‑ATM↑, γH2AX↑, ALDOB↑, ENO3↑, FBP1↑, GSK‐3β↑, HK3↑, PCK1↑, PGK2↑, PGM1↑, PGM3↑, PHKG1↑, PKLR↑, HK2↓, PCNA↓,

Showing Research Papers: 1 to 1 of 1

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:


NA, unassigned(tgid=0) ⓘ

ALDOB↑, 1,   ENO3↑, 1,   H3K9↓, 1,   HK3↑, 1,   PGK2↑, 1,   PGM3↑, 1,   PHKG1↑, 1,   PKLR↑, 1,  

Redox & Oxidative Stress(tgid=1) ⓘ

ROS↑, 1,   Trx1↓, 1,   TrxR↓, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

ATP↓, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

FBP1↑, 1,   GlucoseCon↓, 1,   HK2↓, 1,   lactateProd↓, 1,   PCK1↑, 1,   PGM1↑, 1,  

Cell Death(tgid=5) ⓘ

Apoptosis↑, 1,   JNK↑, 1,   YAP/TEAD↑, 1,  

DNA Damage & Repair(tgid=10) ⓘ

ATM↑, 1,   p‑ATM↑, 1,   PCNA↓, 1,   γH2AX↑, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

GSK‐3β↑, 1,   HMTs↓, 1,  

Migration(tgid=13) ⓘ

TumCP↓, 1,  
Total Targets: 28

Pathway results for Effect on Normal Cells:


Total Targets: 0

Scientific Paper Hit Count for: PKLR, pyruvate kinase L/R
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:1601  State#:%  Dir#:2
  wNotes=0  sortOrder:rid,rpid

 

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