DA Cancer Research Results

DA, dopamine: Click to Expand ⟱
Source:
Type:

Dopamine (DA) is a catecholamine neurotransmitter and neurohormone involved in movement, motivation, reward, cognition, memory, attention and endocrine regulation. Dopamine acts primarily through five G-protein-coupled receptors, DRD1–DRD5, which can produce different and sometimes opposing biological effects. In Alzheimer’s disease, dopaminergic dysfunction and reduced dopamine signalling have been associated with cognitive decline, memory impairment and neuropsychiatric symptoms, suggesting that the typical AD-associated direction is generally down or dysregulated. In cancer, dopamine signalling is context-dependent: dopamine receptors can regulate tumour-cell proliferation, stemness, angiogenesis, migration, apoptosis and antitumour immunity, but individual receptors may be either tumour-promoting or tumour-suppressive depending on the cancer type.



Scientific Papers found: Click to Expand⟱
7212- GBE,    The Use of Ginkgo Biloba L. as a Neuroprotective Agent in the Alzheimer’s Disease
- Review, AD, NA
*antiOx↑, *ROS↓, *mitResp↑, *Casp9↓, *Casp3↓, *Apoptosis↓, *ATP↑, *neuroP↑, *IL1β↓, *IL6↓, *TNF-α↓, *PGE2↓, *memory↑, *cognitive↑, *BloodF↑, *lipid-P↓, *Aβ↓, *MAOA↓, *DA↑, *Dose↝, *toxicity↓,

Showing Research Papers: 1 to 1 of 1

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:


Total Targets: 0

Pathway results for Effect on Normal Cells:


NA, unassigned(tgid=0) ⓘ

DA↑, 1,  

Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↑, 1,   lipid-P↓, 1,   ROS↓, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

ATP↑, 1,   mitResp↑, 1,  

Cell Death(tgid=5) ⓘ

Apoptosis↓, 1,   Casp3↓, 1,   Casp9↓, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

IL1β↓, 1,   IL6↓, 1,   PGE2↓, 1,   TNF-α↓, 1,  

Synaptic & Neurotransmission(tgid=18) ⓘ

MAOA↓, 1,  

Protein Aggregation(tgid=19) ⓘ

Aβ↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

Dose↝, 1,  

Clinical Biomarkers(tgid=22) ⓘ

BloodF↑, 1,   IL6↓, 1,  

Functional Outcomes(tgid=23) ⓘ

cognitive↑, 1,   memory↑, 1,   neuroP↑, 1,   toxicity↓, 1,  
Total Targets: 22

Scientific Paper Hit Count for: DA, dopamine
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:1610  State#:%  Dir#:2
  wNotes=0  sortOrder:rid,rpid

 

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