DA Cancer Research Results

DA, dopamine: Click to Expand ⟱
Source:
Type:

Dopamine (DA) is a catecholamine neurotransmitter and neurohormone involved in movement, motivation, reward, cognition, memory, attention and endocrine regulation. Dopamine acts primarily through five G-protein-coupled receptors, DRD1–DRD5, which can produce different and sometimes opposing biological effects. In Alzheimer’s disease, dopaminergic dysfunction and reduced dopamine signalling have been associated with cognitive decline, memory impairment and neuropsychiatric symptoms, suggesting that the typical AD-associated direction is generally down or dysregulated. In cancer, dopamine signalling is context-dependent: dopamine receptors can regulate tumour-cell proliferation, stemness, angiogenesis, migration, apoptosis and antitumour immunity, but individual receptors may be either tumour-promoting or tumour-suppressive depending on the cancer type.



Scientific Papers found: Click to Expand⟱
7212- GBE,    The Use of Ginkgo Biloba L. as a Neuroprotective Agent in the Alzheimer’s Disease
- Review, AD, NA
*antiOx↑, The antioxidant effects of EGb 761 are mainly related to its influence on cerebral blood flow, the neurotransmitter system, cellular redox state and the level of nitric oxide
*ROS↓, EGb 761 works directly by scavenging ROS or increasing the expression of genes encoding antioxidant enzymes
*mitResp↑, When used, it reduces oxidative stress, improving mitochondrial respiration (Müller et al., 2019) and protects cells from NO-induced neurotoxicity by reducing the increase in caspase-9 activity that activates caspase-3, leading to cell apoptosis
*Casp9↓,
*Casp3↓,
*Apoptosis↓,
*ATP↑, EGb 761 reduces the production of ROS in the mitochondria and protects the mitochondrial complexes of the respiratory chain and increases the availability of ATP
*neuroP↑, Neuroprotective Effect of G. biloba
*IL1β↓, IL-1β, IL-6 and TNFα, causing pro-inflammatory reactions, however, anti-inflammatory cytokines such as IL-4, IL-13 and Arg-1 are also secreted in microglia activation. The use of EGb 761 significantly reduces the above-mentioned cytotoxic mediators,
*IL6↓,
*TNF-α↓,
*PGE2↓, EGb 761 extract strongly inhibits LPS-induced prostaglandin E2 (PGE 2) production mediated by cyclooxygenase 2 (COX-2)
*memory↑, The main reasons for the improvement in memory and cognitive functions after the use of G. biloba include: increased blood flow in the brain, protective effect against peroxidation of brain lipids, easier utilization of oxygen and glucose by brain ce
*cognitive↑,
*BloodF↑,
*lipid-P↓,
*Aβ↓, reduction of amyloid plaque deposition
*MAOA↓, EGb 761 can effectively reduce the activity of MAO, as well as increasing the level of dopamine, especially in the prefrontal cortex
*DA↑,
*Dose↝, In general, the EGb 761 extract is well tolerated and safe up to a dose of 240 mg/day
*toxicity↓, The oral LD50 in mice is 2,100 times the recommended daily dose


Showing Research Papers: 1 to 1 of 1

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:


Total Targets: 0

Pathway results for Effect on Normal Cells:


NA, unassigned(tgid=0) ⓘ

DA↑, 1,  

Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↑, 1,   lipid-P↓, 1,   ROS↓, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

ATP↑, 1,   mitResp↑, 1,  

Cell Death(tgid=5) ⓘ

Apoptosis↓, 1,   Casp3↓, 1,   Casp9↓, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

IL1β↓, 1,   IL6↓, 1,   PGE2↓, 1,   TNF-α↓, 1,  

Synaptic & Neurotransmission(tgid=18) ⓘ

MAOA↓, 1,  

Protein Aggregation(tgid=19) ⓘ

Aβ↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

Dose↝, 1,  

Clinical Biomarkers(tgid=22) ⓘ

BloodF↑, 1,   IL6↓, 1,  

Functional Outcomes(tgid=23) ⓘ

cognitive↑, 1,   memory↑, 1,   neuroP↑, 1,   toxicity↓, 1,  
Total Targets: 22

Scientific Paper Hit Count for: DA, dopamine
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:1610  State#:%  Dir#:2
  wNotes=on  sortOrder:rid,rpid

 

Home Page