LPAR1/EDG2 Cancer Research Results

LPAR1/EDG2, Lysophosphatidic Acid Receptor 1: Click to Expand ⟱
Source:
Type:

LPAR1 - Lysophosphatidic Acid Receptor 1

Abbreviation: LPAR1, LPA1, EDG2

Type: G protein-coupled receptor (GPCR) / lysophosphatidic acid receptor

Function: Cell-surface receptor for lysophosphatidic acid (LPA) that regulates cell survival, proliferation, migration, cytoskeletal remodeling, adhesion, and invasion through signaling pathways including RhoA/ROCK, PI3K/AKT, MAPK, and related downstream pathways.

Cancer: ↑ Frequently increased or overactivated in tumor progression. LPA-LPAR1 signaling can promote proliferation, migration, invasion, epithelial-mesenchymal transition, angiogenic signaling, and metastasis. Increased LPAR1 expression has been associated with more invasive or metastatic phenotypes in several cancers, while LPAR1 inhibition or knockdown can suppress LPA-induced invasion and metastatic behavior.
Scientific Papers found: Click to Expand⟱
7296- Gins,    Korean Red Ginseng Marc-Derived Gintonin Improves Alzheimer's Cognitive Dysfunction by Upregulating LPAR1
- vitro+vivo, AD, SH-SY5Y
*MAPK↓, down-regulated the p38 MAPK, NF-κB p65, and STAT3 signaling pathways.
*NF-kB↓,
*STAT3↓,
*ROS↓, KRGM-G also prevented the formation of reactive oxygen species and stimulated the Nrf2-HO-1/4-HNE signaling pathway in the brains of [Formula: see text] mice and SH-SY5Y cells.
*NRF2↑,
*HO-1↑,
*HNE↑,
*LPAR1/EDG2↑, associated with up-regulation of LPAR1 in the brains of [Formula: see text] mice.
*cognitive↑, results suggest that KRGM-G might improve AD-related cognitive dysfunction by stimulating the anti-oxidant pathway (Nrf2) and inhibiting inflammatory pathways (p38/NF-κB/STAT3) through LPAR1.


Showing Research Papers: 1 to 1 of 1

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:


Total Targets: 0

Pathway results for Effect on Normal Cells:


NA, unassigned(tgid=0) ⓘ

LPAR1/EDG2↑, 1,  

Redox & Oxidative Stress(tgid=1) ⓘ

HNE↑, 1,   HO-1↑, 1,   NRF2↑, 1,   ROS↓, 1,  

Cell Death(tgid=5) ⓘ

MAPK↓, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

STAT3↓, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

NF-kB↓, 1,  

Functional Outcomes(tgid=23) ⓘ

cognitive↑, 1,  
Total Targets: 9

Scientific Paper Hit Count for: LPAR1/EDG2, Lysophosphatidic Acid Receptor 1
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:1619  State#:%  Dir#:2
  wNotes=on  sortOrder:rid,rpid

 

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