IGF-2R Cancer Research Results

IGF-2R, Insulin-Like Growth Factor 2 Receptor: Click to Expand ⟱
Source:
Type:

IGF-2R - Insulin-Like Growth Factor 2 Receptor

Abbreviation: IGF-2R, IGF2R, CI-M6PR, M6P/IGF2R

Type: Growth-factor scavenger receptor / cation-independent mannose-6-phosphate receptor

Function: Cell-surface and intracellular trafficking receptor that binds insulin-like growth factor 2 (IGF-2) and mannose-6-phosphate-containing proteins. IGF2R internalizes and directs IGF-2 toward lysosomal degradation, thereby limiting IGF-2-mediated mitogenic signaling. It also regulates lysosomal enzyme trafficking and contributes to activation of TGF-β.

Cancer: ↓ Frequently reduced, mutated, or lost in cancer and generally functions as a tumor suppressor. Loss of IGF2R can increase extracellular IGF-2 availability and enhance proliferative IGF signaling. Loss of heterozygosity and inactivating alterations of IGF2R have been reported in multiple malignancies and can be associated with tumor progression and poorer outcome.
Scientific Papers found: Click to Expand⟱
7324- GSE,    A Pilot Study of a Grape Seed Procyanidin Extract for Lung Cancer Chemoprevention
- Trial, Lung, NA
BioAv↑, a standardized GSE complexed with soy phospholipids to enhance bio-availability, in heavy active and former smokers
toxicity↝, In general, three months of LP, reaching the highest dose per study protocol was well tolerated and no dosing adjustment was necessary.
Ki-67↓, significantly decreased bronchial Ki-67 LI by an average of 55%
miR-106b↓, with concomitant decreases in serum microRNA (miR) -19a, -19b and -106b
chemoPv↑, findings nonetheless support the continued clinical translation of GSE as an anti-neoplastic and chemopreventive agent against lung cancer.
Dose↝, 1 capsule (cap), 450 mg/cap/day for week one, 2 caps/day for week 2, 3 caps/day for week 3, then 4 cap/day for the rest of the treatment duration as tolerated.
miR-19b↓, Figure 5 downregulating oncomirs miR19-a, -19b, -106b a
PTEN↑, increases in tumor suppressors PTEN, IGF2R and decrease in activated p-Akt by miR-19a/b
IGF-2R↑,
p‑Akt↓,
PGE2↓, decreases in PGE2 and PGI2 due to COX-2 inhibition
PGI2↓,
COX2/PTGS2↓,
Apoptosis↑, GSE increases apoptosis, decreases cell proliferation, decreases inflammation,
TumCP↓,
Inflam↓,
cardioP↑, favorable side effect profiles that may also be cardio-protective,

7322- GSE,    MicroRNA-19a/b mediates grape seed procyanidin extract-induced anti-neoplastic effects against lung cancer
- vitro+vivo, Lung, A549 - in-vitro, Lung, H520 - in-vitro, Lung, H1299 - in-vitro, Nor, BEAS-2B
miR-19b↓, We found that GSE significantly down-regulated oncomirs miR-19a and −19b in a variety of lung neoplastic cells.
IGF-2R↑, GSE also increased mRNA and protein levels of insulin-like growth factor II receptor (IGF-2R) and phosphatase and tensin homolog (PTEN), both predicted targets of miR-19a and −19b.
PTEN↑,
p‑Akt↓, Furthermore, GSE significantly increased PTEN activity and decreased AKT phosphorylation in A549 cells.
Dose↝, All dosing regimen − 200, 300 and 400 mg/kg/day (containing GSE 56, 84, 112 mg/kg/day, respectively) for up to 8 weeks were well tolerated by nude mice.


Showing Research Papers: 1 to 2 of 2

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 2

Pathway results for Effect on Cancer / Diseased Cells:


NA, unassigned(tgid=0) ⓘ

IGF-2R↑, 2,   miR-106b↓, 1,   PGI2↓, 1,  

Cell Death(tgid=5) ⓘ

p‑Akt↓, 2,   Apoptosis↑, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

PTEN↑, 2,  

Migration(tgid=13) ⓘ

Ki-67↓, 1,   miR-19b↓, 2,   TumCP↓, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

COX2/PTGS2↓, 1,   Inflam↓, 1,   PGE2↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↑, 1,   Dose↝, 2,  

Clinical Biomarkers(tgid=22) ⓘ

Ki-67↓, 1,  

Functional Outcomes(tgid=23) ⓘ

cardioP↑, 1,   chemoPv↑, 1,   toxicity↝, 1,  
Total Targets: 18

Pathway results for Effect on Normal Cells:


Total Targets: 0

Scientific Paper Hit Count for: IGF-2R, Insulin-Like Growth Factor 2 Receptor
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:1625  State#:%  Dir#:2
  wNotes=on  sortOrder:rid,rpid

 

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