PGE3 Cancer Research Results

PGE3, Prostaglandin E3: Click to Expand ⟱
Source:
Type:

PGE3 - Prostaglandin E3

Abbreviation: PGE3

Type: EPA-derived prostaglandin / 3-series eicosanoid lipid mediator

Function: Bioactive prostaglandin derived from eicosapentaenoic acid (EPA) through cyclooxygenase-dependent metabolism. PGE3 can signal through prostaglandin E receptors and generally produces less pro-inflammatory signaling than the arachidonic-acid-derived PGE2. It participates in regulation of inflammation, proliferation, apoptosis, angiogenesis, and immune-cell behavior.

Cancer: ↑ Generally associated with anti-cancer activity. Increased PGE3 formation from EPA can inhibit tumor-cell proliferation, angiogenesis, invasion, and survival and can promote apoptosis. PGE3 may also suppress tumor-promoting macrophage polarization and contribute to the anticancer effects of EPA and omega-3 fatty acids.
Scientific Papers found: Click to Expand⟱
7326- GSE,    LEUCOSELECT PHYTOSOME MODULATES SERUM EICOSAPENTAENOIC ACID, DOCOSAHEXAENOIC ACID and PROSTAGLANDIN E3 IN A PHASE 1 LUNG CANCER CHEMOPREVENTION STUDY
- in-vitro, Lung, A549 - in-vitro, Lung, H520
antiNeop↑, Grape seed procyanidin extract (GSE) has been shown to exert antineoplastic properties in preclinical studies.
Ki-67↓, Three months of LP treatment significantly decreased bronchial Ki-67 labeling index (LI), a marker of cell proliferation on the bronchial epithelium.
other↑, One month of LP treatment significantly increases eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), the omega-3 polyunsaturated fatty acids (n-3 PUFA)s with well-established anti-cancer properties.
PGE3↑, Furthermore, 3 month of LP treatment significantly increases serum prostaglanding (PG) E3, a metabolite of EPA with anti-inflammatory and antineoplastic properties.


Showing Research Papers: 1 to 1 of 1

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:


NA, unassigned(tgid=0) ⓘ

PGE3↑, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

other↑, 1,  

Migration(tgid=13) ⓘ

Ki-67↓, 1,  

Clinical Biomarkers(tgid=22) ⓘ

Ki-67↓, 1,  

Functional Outcomes(tgid=23) ⓘ

antiNeop↑, 1,  
Total Targets: 5

Pathway results for Effect on Normal Cells:


Total Targets: 0

Scientific Paper Hit Count for: PGE3, Prostaglandin E3
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:1628  State#:%  Dir#:2
  wNotes=on  sortOrder:rid,rpid

 

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