CD19 Cancer Research Results

CD19, D19 Molecule / B-Lymphocyte Antigen CD19: Click to Expand ⟱
Source:
Type:

CD19 - CD19 Molecule / B-Lymphocyte Antigen CD19

Type: B-cell surface receptor / co-receptor / therapeutic tumor antigen

Function: Transmembrane glycoprotein expressed primarily on B-lineage cells that functions as part of the B-cell receptor co-receptor complex. CD19 amplifies B-cell receptor signaling and regulates B-cell activation, proliferation, differentiation, and immune responses.

Cancer: ↑ Highly expressed on the majority of B-cell leukemias and lymphomas and serves as a major therapeutic tumor-associated antigen. CD19 is targeted by CAR-T cells, bispecific antibodies, and other antibody-based therapies. Loss or downregulation of CD19 can permit antigen escape and relapse following CD19-directed treatment.
Scientific Papers found: Click to Expand⟱
7399- Amla,    Molecular Mechanisms of Cancer Prevention by Gooseberry (Phyllanthus emblica)
- Review, Var, NA
*Dose↝, P. emblica fruit is the second richest known source of vitamin C (4), as well as having high levels of tannins, alkaloids, polyphenols, vitamins, and minerals. P. emblica contains several biologically-active antioxidant polyphenols, including gallic
*Inflam↓, gooseberry constituents possess anti-inflammatory, anticancer, anti-microbial, and anti-oxidant effects which protect against neurological disorders, have hepatoprotective and cardioprotective activities, and are cancer-preventive
*AntiCan↑,
*antiOx↑,
*neuroP↑,
*hepatoP↑,
*cardioP↑,
*P450↓, via inhibition of cytochrome P450 (CYP450) isozymes
*SOD↑, figure 3
*GPx↑,
*Catalase↑,
*ROS↓,
*CD4+↑,
*CD19↑,
*NK cell↑,
Casp3↑,
Casp7↑,
Casp8↑,
Casp9↑,
Fas↑,
BAX↑,
Bcl-2↓,
*IL10↑,
*TNF-α↓,
*IL6↓,
*iNOS↓,
*COX2↓,
*GSTs↑,
*NF-kB↓,
*AP-1↓,
*cJun↓,
*lipid-P↓, P. emblica extracts scavenge free radicals, protect against lipid peroxidation, and thus may play a role in preventing diseases associated with oxidative stress, including cancer.
TumCG↓, P. emblica extract (50–100 μg/ml) significantly inhibits the cell growth of human colorectal (SW620), lung (A549), breast (MDA-MB-231), cervical (HeLa), ovarian (SK-OV3), and liver (HepG2) cancer cell lines
DNAdam↑, apoptosis was induced by triggering of DNA fragmentation, caspase-3, −7, and −8 activity, and Fas protein expression
TumCCA↑, inducing G2/M phase cell cycle arrest and promoting apoptosis via increasing expression of Fas, FasL, and cleaved caspase-8
MMP2↓, P. emblica extract (1–3 µg/ml) decreases the expression of both MMP2 and MMP9 in human fibrosarcoma (HT1080) cells,
MMP9↓,


Showing Research Papers: 1 to 1 of 1

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:


Cell Death(tgid=5) ⓘ

BAX↑, 1,   Bcl-2↓, 1,   Casp3↑, 1,   Casp7↑, 1,   Casp8↑, 1,   Casp9↑, 1,   Fas↑, 1,  

DNA Damage & Repair(tgid=10) ⓘ

DNAdam↑, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

TumCCA↑, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

TumCG↓, 1,  

Migration(tgid=13) ⓘ

MMP2↓, 1,   MMP9↓, 1,  
Total Targets: 12

Pathway results for Effect on Normal Cells:


NA, unassigned(tgid=0) ⓘ

CD19↑, 1,  

Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↑, 1,   Catalase↑, 1,   GPx↑, 1,   GSTs↑, 1,   lipid-P↓, 1,   ROS↓, 1,   SOD↑, 1,  

Cell Death(tgid=5) ⓘ

iNOS↓, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

cJun↓, 1,  

Migration(tgid=13) ⓘ

AP-1↓, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

CD4+↑, 1,   COX2↓, 1,   IL10↑, 1,   IL6↓, 1,   Inflam↓, 1,   NF-kB↓, 1,   NK cell↑, 1,   TNF-α↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

Dose↝, 1,   P450↓, 1,  

Clinical Biomarkers(tgid=22) ⓘ

IL6↓, 1,  

Functional Outcomes(tgid=23) ⓘ

AntiCan↑, 1,   cardioP↑, 1,   hepatoP↑, 1,   neuroP↑, 1,  
Total Targets: 26

Scientific Paper Hit Count for: CD19, D19 Molecule / B-Lymphocyte Antigen CD19
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:1639  State#:%  Dir#:2
  wNotes=on  sortOrder:rid,rpid

 

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