BHB Cancer Research Results

BHB, Beta-Hydroxybutyrate: Click to Expand ⟱
Source:
Type:

β-Hydroxybutyrate - Beta-Hydroxybutyrate / 3-Hydroxybutyrate

Abbreviation: BHB, β-HB,β-HOB

Type: Ketone body / metabolic and signaling metabolite

Function: β-Hydroxybutyrate is a major circulating ketone body produced primarily by the liver during fasting, carbohydrate restriction, prolonged exercise, or ketogenic metabolism. It serves as an alternative mitochondrial energy substrate and also functions as a signaling metabolite that can regulate NLRP3 inflammasome activity, histone deacetylase activity, oxidative stress, mitochondrial function, gene expression, and inflammatory responses.

Cancer: ↕ Context-dependent. β-Hydroxybutyrate can inhibit inflammatory and growth-related signaling and has demonstrated anti-proliferative and anti-migratory effects in some experimental cancer models. However, metabolic utilization of ketone bodies varies among cancers, and some tumor cells can use β-hydroxybutyrate as an energy or biosynthetic substrate.

Alzheimer's Disease: ↑ Generally neuroprotective. β-Hydroxybutyrate provides an alternative energy substrate when cerebral glucose metabolism is impaired and can inhibit NLRP3 inflammasome activation, reduce microglial neuroinflammation, improve mitochondrial function, and reduce oxidative stress. Experimental studies support beneficial effects on cognition and Alzheimer's-related pathology.
Scientific Papers found: Click to Expand⟱
7483- H2,  Cisplatin,    Molecular hydrogen attenuates cisplatin-induced nephrotoxicity by modulating β-hydroxybutyrate metabolism
- in-vivo, Nor, HK-2
RenoP↑, H2 inhalation significantly attenuated cisplatin-induced kidney injury by reducing inflammation and apoptosis in renal tissue.
BHB↑, H2 upregulated the ketone body metabolic pathway, particularly enhancing β-hydroxybutyrate (β-HOB) synthesis via increased expression of the ketogenic enzyme 3-hydroxy-3-methylglutaryl-CoA synthase 2 (HMGCS2).
HMGCS2↑,
chemoP↑, Molecular hydrogen confers protection against cisplatin-induced nephrotoxicity by modulating β-HOB metabolism through upregulation of HMGCS2, thereby suppressing renal inflammation and apoptosis.
*IL2↓, IL-1β, IL-6, MCP-1, and TNF-α in kidney tissue. Levels of these proinflammatory mediators were significantly elevated following cisplatin treatment. H2 inhalation significantly suppressed these cytokines,
*IL6↓,
*MCP1/CCL2↓,
*TNF-α↓,
*KeyT↝, H2 upregulated HMGCS2 to enhance ketone body metabolism
*Inflam↓, H2 has been demonstrated protective effects in various inflammatory and oxidative stress-related conditions
*ROS↓,
*MMP↑, Several studies have shown that H2 can preserve mitochondrial membrane potential, boost ATP generation, and improve mitochondrial dynamics and biogenesis by activating pathways such as mitofusin-2 (Mfn2) and PGC-1α
*ATP↑,
*MFN2↑,
*PGC-1α↑,
*BUN↓, Our work confirmed that H2 inhalation significantly ameliorated cisplatin-induced histological damage, elevated BUN and creatinine levels, renal inflammation, and tubular apoptosis.
*creat↓,


Showing Research Papers: 1 to 1 of 1

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:


NA, unassigned(tgid=0) ⓘ

BHB↑, 1,   HMGCS2↑, 1,  

Functional Outcomes(tgid=23) ⓘ

chemoP↑, 1,   RenoP↑, 1,  
Total Targets: 4

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

MFN2↑, 1,   ROS↓, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

ATP↑, 1,   MMP↑, 1,   PGC-1α↑, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

BUN↓, 1,   KeyT↝, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

IL2↓, 1,   IL6↓, 1,   Inflam↓, 1,   MCP1/CCL2↓, 1,   TNF-α↓, 1,  

Clinical Biomarkers(tgid=22) ⓘ

creat↓, 1,   IL6↓, 1,  
Total Targets: 14

Scientific Paper Hit Count for: BHB, Beta-Hydroxybutyrate
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:1645  State#:%  Dir#:2
  wNotes=on  sortOrder:rid,rpid

 

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