HMGCS2 Cancer Research Results

HMGCS2, 3-Hydroxy-3-Methylglutaryl-CoA Synthase 2: Click to Expand ⟱
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Type:

HMGCS2 - 3-Hydroxy-3-Methylglutaryl-CoA Synthase 2

Abbreviation: HMGCS2, mitochondrial HMG-CoA synthase

Type: Mitochondrial metabolic enzyme / ketogenesis enzyme

Function: Catalyzes the condensation of acetyl-CoA with acetoacetyl-CoA to form HMG-CoA and is the rate-limiting enzyme of mitochondrial ketogenesis. HMGCS2 regulates production of ketone bodies including β-hydroxybutyrate and acetoacetate and links fatty-acid oxidation, mitochondrial metabolism, cellular energy status, and metabolic signaling.

Cancer: ↕ Context-dependent. HMGCS2 functions as a tumor suppressor in several cancers, where reduced expression can promote proliferation, migration, invasion, and tumor progression and restoration of HMGCS2 can suppress malignant behavior. However, HMGCS2-dependent ketogenesis can support metabolic adaptation and survival in selected tumor contexts, making its role dependent on cancer type and metabolic state.
Scientific Papers found: Click to Expand⟱
7483- H2,  Cisplatin,    Molecular hydrogen attenuates cisplatin-induced nephrotoxicity by modulating β-hydroxybutyrate metabolism
- in-vivo, Nor, HK-2
RenoP↑, BHB↑, HMGCS2↑, chemoP↑, *IL2↓, *IL6↓, *MCP1/CCL2↓, *TNF-α↓, *KeyT↝, *Inflam↓, *ROS↓, *MMP↑, *ATP↑, *MFN2↑, *PGC-1α↑, *BUN↓, *creat↓,

Showing Research Papers: 1 to 1 of 1

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:


NA, unassigned(tgid=0) ⓘ

BHB↑, 1,   HMGCS2↑, 1,  

Functional Outcomes(tgid=23) ⓘ

chemoP↑, 1,   RenoP↑, 1,  
Total Targets: 4

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

MFN2↑, 1,   ROS↓, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

ATP↑, 1,   MMP↑, 1,   PGC-1α↑, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

BUN↓, 1,   KeyT↝, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

IL2↓, 1,   IL6↓, 1,   Inflam↓, 1,   MCP1/CCL2↓, 1,   TNF-α↓, 1,  

Clinical Biomarkers(tgid=22) ⓘ

creat↓, 1,   IL6↓, 1,  
Total Targets: 14

Scientific Paper Hit Count for: HMGCS2, 3-Hydroxy-3-Methylglutaryl-CoA Synthase 2
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:1646  State#:%  Dir#:2
  wNotes=0  sortOrder:rid,rpid

 

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