CBS Cancer Research Results

CBS, Cystathionine Beta-Synthase: Click to Expand ⟱
Source:
Type:

CBS - Cystathionine Beta-Synthase

Type: Transsulfuration enzyme / hydrogen sulfide-producing enzyme

Function: CBS is a pyridoxal phosphate-dependent enzyme that catalyzes the first committed step of the transsulfuration pathway, converting homocysteine toward cystathionine and cysteine synthesis. It also generates hydrogen sulfide (H2S), linking sulfur amino-acid metabolism with glutathione synthesis, redox regulation, mitochondrial bioenergetics, vascular signaling, and cellular stress responses.

Cancer: ↕ Context-dependent, but frequently increased and oncogenic in high-CBS tumors. Elevated CBS-derived H2S can promote mitochondrial bioenergetics, proliferation, survival, angiogenesis, migration, and tumor growth. CBS inhibition or silencing suppresses tumor growth in several experimental models, particularly colorectal and ovarian cancers, although tumor-suppressive roles have been reported in selected cancer types.

Alzheimer's Disease: ↓ Reduced CBS activity and decreased endogenous H2S production have been reported in Alzheimer's disease brain. Loss of CBS/H2S signaling may contribute to impaired neuronal signaling, oxidative stress, inflammation, and cognitive dysfunction.
Scientific Papers found: Click to Expand⟱
7500- H2S,    Hydrogen sulfide ameliorates learning memory impairment in APP/PS1 transgenic mice: A novel mechanism mediated by the activation of Nrf2
- in-vivo, AD, NA
*neuroP↑, Hydrogen sulfide (H2S) has been recognized as a cytoprotectant, which improves learning memory impairment and exerts antioxidant effects in neurodegenerative disorders, including AD.
*memory↑,
*CBS↑, intraperitoneal (i.p.) injection of NaHS improved learning memory deficits, decreased the number of senile plaques, Aβ1-40 and Aβ1-42 levels, suppressed neurons loss, together with up-regulated the levels of cystathionine-β-synthase (CBS) and 3MST
*3MST/MPST↑,
*APP↓, the protein levels of beta-amyloid precursor (APP) and beta-secretase 1 (BACE1) were dramatically restrained after administration of H2S
*BACE↓,
*NRF2↑, H2S exerted antioxidant effects via up-regulation nuclear factor erythroid-2-related factor 2 (Nrf2), heme oxygenase-1(HO-1) and glutathione S-transferase (GST).
*HO-1↑,
*GSTs↑,
*Aβ↓, inhibition of Aβ production and activation of Nrf2/antioxidant response element (ARE) pathway.
*ARE↑,

7502- H2S,    Tumor-derived hydrogen sulfide, produced by cystathionine-β-synthase, stimulates bioenergetics, cell proliferation, and angiogenesis in colon cancer
- in-vitro, CRC, HCT116 - in-vitro, CRC, HT29 - in-vitro, CRC, LoVo
CBS↑, patient-matched normal margin mucosa revealed the selective up-regulation of the H2S-producing enzyme cystathionine-β-synthase (CBS) in colon cancer, resulting in an increased rate of H2S production.
TumCP↑, Tumor-derived hydrogen sulfide, produced by cystathionine-β-synthase, stimulates bioenergetics, cell proliferation, and angiogenesis in colon cancer
angioG↑,

7503- H2S,    Hydrogen Sulfide, an Endogenous Stimulator of Mitochondrial Function in Cancer Cells
- Review, Var, NA
DNArepair↑, endogenous H2S in cancer cells include the maintenance of mitochondrial organization (protection against mitochondrial fission) and the maintenance of mitochondrial DNA repair
CBS↑, CBS is upregulated and H2S generation is increased in primary human colon cancer tissues compared to the surrounding (nominally healthy) tissues
3MST/MPST↑, it is now clear that CBS, and/or CSE and/or 3-MST is overexpressed in many forms of cancer.
ETC↑, H2S can enhance mitochondrial electron transport and ATP production in cancer cells are shown in Figure 1.
ATP↑,
Glycolysis↑, H2S can also stimulate glycolysis (another key energetic process in cancer cells
ACLY↑, recently discovered mechanism relates to the upregulation of ACLY by H2S


Showing Research Papers: 1 to 3 of 3

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 3

Pathway results for Effect on Cancer / Diseased Cells:


NA, unassigned(tgid=0) ⓘ

3MST/MPST↑, 1,   CBS↑, 2,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

ATP↑, 1,   ETC↑, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

ACLY↑, 1,   Glycolysis↑, 1,  

DNA Damage & Repair(tgid=10) ⓘ

DNArepair↑, 1,  

Migration(tgid=13) ⓘ

TumCP↑, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↑, 1,  
Total Targets: 9

Pathway results for Effect on Normal Cells:


NA, unassigned(tgid=0) ⓘ

3MST/MPST↑, 1,   CBS↑, 1,  

Redox & Oxidative Stress(tgid=1) ⓘ

ARE↑, 1,   GSTs↑, 1,   HO-1↑, 1,   NRF2↑, 1,  

Migration(tgid=13) ⓘ

APP↓, 1,  

Protein Aggregation(tgid=19) ⓘ

Aβ↓, 1,   BACE↓, 1,  

Functional Outcomes(tgid=23) ⓘ

memory↑, 1,   neuroP↑, 1,  
Total Targets: 11

Scientific Paper Hit Count for: CBS, Cystathionine Beta-Synthase
3 hydrogen sulfide
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:1651  State#:%  Dir#:2
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