3MST/MPST Cancer Research Results

3MST/MPST, 3-Mercaptopyruvate Sulfurtransferase: Click to Expand ⟱
Source:
Type:

3-MST - 3-Mercaptopyruvate Sulfurtransferase

Type: Sulfurtransferase / hydrogen sulfide-producing enzyme

Function: 3-MST is a sulfurtransferase encoded by MPST that generates hydrogen sulfide (H2S) and related reactive sulfur species primarily from 3-mercaptopyruvate, typically in cooperation with cysteine aminotransferase. 3-MST is present in both mitochondria and cytosol and contributes to mitochondrial bioenergetics, redox regulation, antioxidant defense, vascular signaling, and cellular stress responses.

Cancer: ↕ Context-dependent. Increased 3-MST/MPST-derived H2S can support mitochondrial respiration, redox homeostasis, proliferation, survival, and metabolic adaptation in selected cancers. However, the role of 3-MST varies substantially among tumor types and is less consistently oncogenic than the CBS/H2S pathway. It is now clear that CBS, and/or CSE and/or 3-MST is overexpressed in many forms of cancer.



Scientific Papers found: Click to Expand⟱
7500- H2S,    Hydrogen sulfide ameliorates learning memory impairment in APP/PS1 transgenic mice: A novel mechanism mediated by the activation of Nrf2
- in-vivo, AD, NA
*neuroP↑, Hydrogen sulfide (H2S) has been recognized as a cytoprotectant, which improves learning memory impairment and exerts antioxidant effects in neurodegenerative disorders, including AD.
*memory↑,
*CBS↑, intraperitoneal (i.p.) injection of NaHS improved learning memory deficits, decreased the number of senile plaques, Aβ1-40 and Aβ1-42 levels, suppressed neurons loss, together with up-regulated the levels of cystathionine-β-synthase (CBS) and 3MST
*3MST/MPST↑,
*APP↓, the protein levels of beta-amyloid precursor (APP) and beta-secretase 1 (BACE1) were dramatically restrained after administration of H2S
*BACE↓,
*NRF2↑, H2S exerted antioxidant effects via up-regulation nuclear factor erythroid-2-related factor 2 (Nrf2), heme oxygenase-1(HO-1) and glutathione S-transferase (GST).
*HO-1↑,
*GSTs↑,
*Aβ↓, inhibition of Aβ production and activation of Nrf2/antioxidant response element (ARE) pathway.
*ARE↑,

7503- H2S,    Hydrogen Sulfide, an Endogenous Stimulator of Mitochondrial Function in Cancer Cells
- Review, Var, NA
DNArepair↑, endogenous H2S in cancer cells include the maintenance of mitochondrial organization (protection against mitochondrial fission) and the maintenance of mitochondrial DNA repair
CBS↑, CBS is upregulated and H2S generation is increased in primary human colon cancer tissues compared to the surrounding (nominally healthy) tissues
3MST/MPST↑, it is now clear that CBS, and/or CSE and/or 3-MST is overexpressed in many forms of cancer.
ETC↑, H2S can enhance mitochondrial electron transport and ATP production in cancer cells are shown in Figure 1.
ATP↑,
Glycolysis↑, H2S can also stimulate glycolysis (another key energetic process in cancer cells
ACLY↑, recently discovered mechanism relates to the upregulation of ACLY by H2S


Showing Research Papers: 1 to 2 of 2

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 2

Pathway results for Effect on Cancer / Diseased Cells:


NA, unassigned(tgid=0) ⓘ

3MST/MPST↑, 1,   CBS↑, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

ATP↑, 1,   ETC↑, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

ACLY↑, 1,   Glycolysis↑, 1,  

DNA Damage & Repair(tgid=10) ⓘ

DNArepair↑, 1,  
Total Targets: 7

Pathway results for Effect on Normal Cells:


NA, unassigned(tgid=0) ⓘ

3MST/MPST↑, 1,   CBS↑, 1,  

Redox & Oxidative Stress(tgid=1) ⓘ

ARE↑, 1,   GSTs↑, 1,   HO-1↑, 1,   NRF2↑, 1,  

Migration(tgid=13) ⓘ

APP↓, 1,  

Protein Aggregation(tgid=19) ⓘ

Aβ↓, 1,   BACE↓, 1,  

Functional Outcomes(tgid=23) ⓘ

memory↑, 1,   neuroP↑, 1,  
Total Targets: 11

Scientific Paper Hit Count for: 3MST/MPST, 3-Mercaptopyruvate Sulfurtransferase
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:1652  State#:%  Dir#:2
  wNotes=on  sortOrder:rid,rpid

 

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