TRADD Cancer Research Results

TRADD, TNF Receptor Type 1-Associated Death Domain Protein: Click to Expand ⟱
Source:
Type:

TRADD - TNF Receptor Type 1-Associated Death Domain Protein

Type: Death-domain adaptor protein / TNF receptor signaling protein

Function: TRADD is a signaling adaptor recruited primarily to TNFR1 and other death-domain-containing receptors. It provides a platform for recruitment of proteins including TRAF2, RIPK1, and FADD and can regulate NF-κB and MAPK activation, inflammation, apoptosis, necroptosis, cell survival, and proliferation.

Cancer: ↕ Context-dependent. TRADD can promote tumor-suppressive death-receptor signaling through recruitment of FADD and activation of caspase-mediated apoptosis. However, TRADD can also activate NF-κB, MAPK, and inflammatory survival pathways that support proliferation and tumor-cell survival. Its net cancer effect therefore depends on receptor, cellular context, and downstream signaling-complex formation.
Scientific Papers found: Click to Expand⟱
7507- FA,    Assessment of the anticancer mechanism of ferulic acid via cell cycle and apoptotic pathways in human prostate cancer cell lines
- in-vitro, Pca, LNCaP - in-vitro, Pca, PC3
Dose↝, The half maximal inhibitory concentration (IC50) dose of FA was found to be 300 μM in PC-3 cells and 500 μM in LNCaP cells.
ATR↑, FA inhibited cell proliferation by increasing the gene expressions of ATR, ATM, CDKN1A, CDKN1B, E2F4, RB1, and TP53
ATM↑,
P21↑,
p27/CDKN1B↑,
E2F4↑,
RB1↑,
TP53↑,
cycD1/CCND1↓, and decreasing the gene expressions of CCND1, CCND2, CCND3, CDK2, CDK4, and CDK6 in PC-3 cells.
CDK2↓,
CDK4↓,
CDK6↓,
TumCP↓, suppressed cell proliferation by increasing in the gene expressions of CASP1, CASP2, CASP8, CYCS, FAS, FASLG, and TRADD
Casp1↑,
Casp2↑,
Casp8↑,
Fas↑,
TRADD↑,
Bcl-2↓, and decreasing in the gene expressions of BCL2 and XIAP in LNCaP cells
XIAP↓,
TumCCA↑, FA may lead to cell cycle arrest in PC-3 cells while it may cause apoptosis in LNCaP cells.


Showing Research Papers: 1 to 1 of 1

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:


NA, unassigned(tgid=0) ⓘ

E2F4↑, 1,   TRADD↑, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

XIAP↓, 1,  

Cell Death(tgid=5) ⓘ

Bcl-2↓, 1,   Casp1↑, 1,   Casp2↑, 1,   Casp8↑, 1,   Fas↑, 1,   p27/CDKN1B↑, 1,  

DNA Damage & Repair(tgid=10) ⓘ

ATM↑, 1,   ATR↑, 1,   TP53↑, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

CDK2↓, 1,   CDK4↓, 1,   cycD1/CCND1↓, 1,   P21↑, 1,   RB1↑, 1,   TumCCA↑, 1,  

Migration(tgid=13) ⓘ

TumCP↓, 1,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

CDK6↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

Dose↝, 1,  

Clinical Biomarkers(tgid=22) ⓘ

TP53↑, 1,  
Total Targets: 22

Pathway results for Effect on Normal Cells:


Total Targets: 0

Scientific Paper Hit Count for: TRADD, TNF Receptor Type 1-Associated Death Domain Protein
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:1654  State#:%  Dir#:2
  wNotes=on  sortOrder:rid,rpid

 

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