ATG13 Cancer Research Results

ATG13, Autophagy Related 13: Click to Expand ⟱
Source:
Type:

ATG13 - Autophagy Related 13

Type: Autophagy initiation protein / ULK complex component

Function: ATG13 is a core component of the ULK1/ULK2 autophagy-initiation complex together with ULK1/2, FIP200/RB1CC1, and ATG101. It acts as a regulatory and scaffold protein that helps assemble and activate the autophagy machinery in response to nutrient, energy, mTORC1, and AMPK signaling, promoting phagophore formation and autophagosome biogenesis.

Cancer: ↕ Context-dependent. ATG13-dependent autophagy can suppress early tumorigenesis by maintaining cellular homeostasis and removing damaged proteins and organelles. However, established cancer cells frequently exploit ATG13-mediated autophagy to survive nutrient deprivation, hypoxia, oxidative stress, and anticancer therapy, contributing to tumor survival and treatment resistance.
Scientific Papers found: Click to Expand⟱
7547- HYP,    Hyperoside suppresses NSCLC progression by inducing ATG13-mediated autophagy and apoptosis
- vitro+vivo, NSCLC, NA
TumCMig↓, TumCP↓, TumCG↓, Apoptosis↑, TumCCA↑, TumAuto↑, ATG13↑,

Showing Research Papers: 1 to 1 of 1

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:


NA, unassigned(tgid=0) ⓘ

ATG13↑, 1,  

Cell Death(tgid=5) ⓘ

Apoptosis↑, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

TumAuto↑, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

TumCCA↑, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

TumCG↓, 1,  

Migration(tgid=13) ⓘ

TumCMig↓, 1,   TumCP↓, 1,  
Total Targets: 7

Pathway results for Effect on Normal Cells:


Total Targets: 0

Scientific Paper Hit Count for: ATG13, Autophagy Related 13
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:1657  State#:%  Dir#:2
  wNotes=0  sortOrder:rid,rpid

 

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