HTRA2/Omi/PARK13 Cancer Research Results

HTRA2/Omi/PARK13, High Temperature Requirement A2: Click to Expand ⟱
Source:
Type:

HTRA2 - High Temperature Requirement A2 / Omi

Abbreviation: HTRA2, Omi, PARK13

Type: Mitochondrial serine protease / apoptosis regulator

Function: HTRA2/Omi is a mitochondrial serine protease involved in mitochondrial protein quality control, cellular stress responses, autophagy, and apoptosis. Under mitochondrial stress, Omi can be released into the cytosol where it antagonizes inhibitor-of-apoptosis proteins (IAPs) and promotes caspase-dependent and caspase-independent cell death.

Cancer: ↕ Context-dependent. Cytosolic HTRA2/Omi can promote tumor-cell apoptosis by antagonizing IAP-mediated survival and activating cell-death pathways, supporting a tumor-suppressive role. However, mitochondrial HTRA2 also maintains mitochondrial homeostasis and stress tolerance, so its overall effect depends on cellular localization, protease activity, and tumor context.

Alzheimer's Disease: ↑ Increased HTRA2/Omi protease activity and increased active/cytosolic Omi have been reported in Alzheimer's disease brain. This altered activity may contribute to mitochondrial dysfunction, cellular stress, and neuronal apoptosis, although total HTRA2 mRNA expression may remain relatively unchanged.
Scientific Papers found: Click to Expand⟱
7591- I3C,    Indole-3-carbinol (I3C)-induced apoptosis in nasopharyngeal cancer cells through Fas/FasL and MAPK pathway
- in-vitro, NPC, CNE2
Apoptosis↑, MMP↓, XIAP↓, IAP1↓, survivin↓, Diablo↑, Cyt‑c↑, HTRA2/Omi/PARK13↑, mtDam↑, Fas↑, FasL↑,

Showing Research Papers: 1 to 1 of 1

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:


NA, unassigned(tgid=0) ⓘ

HTRA2/Omi/PARK13↑, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

MMP↓, 1,   mtDam↑, 1,   XIAP↓, 1,  

Cell Death(tgid=5) ⓘ

Apoptosis↑, 1,   Cyt‑c↑, 1,   Diablo↑, 1,   Fas↑, 1,   FasL↑, 1,   IAP1↓, 1,   survivin↓, 1,  
Total Targets: 11

Pathway results for Effect on Normal Cells:


Total Targets: 0

Scientific Paper Hit Count for: HTRA2/Omi/PARK13, High Temperature Requirement A2
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:1666  State#:%  Dir#:2
  wNotes=0  sortOrder:rid,rpid

 

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